Neutralization of Endogenous Luteinizing Hormone by Antibodies in Prepubertal Female Rats

Schuchner, Elsa B.; R, Monastirsky

doi:10.1016/s0015-0282(16)39491-2

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…Neutralization of endogenous pituitary gonadotrophins by antibodies has been demonstrated previously by several authors (Segal et al, 1962;Talaat & Laurence, 1969;Schwartz & Ely, 1970;Monastirsky et al, 1971;Schuchner & Monastirsky, 1973). Talaat & Laurence (1969) showed that active FSH immunization in rabbits diminished their fertility.…”

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confidence: 67%

“…Recently, it has been demonstrated that foreign gonadotrophins are antigenic in the rabbit (Segal, Laurence, Perlbachs & Hakim, 1962;Talaat & Laurence, 1969;Schwartz & Ely, 1970;Monastirsky, Laurence & Tovar, 1971;Schuchner & Monastirsky, 1973). The aim of this study was to describe the effects of active anti-FSH immunization on the ovarian morphology of adult rabbits and the possible mechanism of action of FSH.…”

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confidence: 99%

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Immunization of Rabbits Against FSH and Effects on the Zona Pellucida

R¹,

Schuchner²,

Deu³

1974

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The effects of active FSH immunization on the ovarian morphology of adult rabbits were studied. Rabbits were immunized intradermally in multiple sites with antibodies to ovine FSH. Both the macroscopic morphology and the weight of the ovaries of the experimental rabbits were similar to those of the controls. Multiple branched projections of the granulosa cells were seen in the experimental rabbits. These projections had higher electron density than the rest of the cell. The zona pellucida was not formed although the growing follicles were large enough to have a completely formed layer. Disturbance of the metabolism of the follicular cells, due to the lack of endogenous FSH, could explain this abnormality.

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confidence: 67%

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confidence: 99%