Neutralization by "antineoplastin" of insulin-activated nitric oxide synthase antibody and its effects in cancers

Sinha, Asru K.; Acharya, Krishnendu; Bhattacharya, Sujoy; Patra, Sharmistha Chakraborty; Guha, Manti; Ray, Udayan; Ray, Shyamali Basu; Khan, Gausal A.; Chakraborty, Kushal; Biswas, Jaydip; Mazumdar, Sahana

doi:10.1007/s00432-002-0376-8

Cited by 10 publications

(26 citation statements)

References 16 publications

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“…These results might suggest an impairment of NOS activity in both breast cancer and other cancers. (15) However, it could be argued that the antimetastatic effect of aspirin in breast cancer patients was not due to the effect of aspirin itself. The prevention of metastasis could be the consequence of the previous therapeutic regimen, and the patients might simply be enjoying a long period of ''disease-free condition''.…”

Section: Discussionmentioning

confidence: 99%

“…We have reported earlier (15) that patients who had received chemotherapy, radiation, and ⁄ or surgery for localized breast cancer lesions could be categorized into two groups, responders and non-responders. The survival rate of metastatic breast cancer patients in the responders and non-responders after they received above mentioned therapies were 65% and 22%, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Acetyl salicyclic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients

et al. 2010

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Maspin, a 42 kDa protein produced in normal breast cells, has been shown to inhibit the invasion and metastasis of breast cancer in an animal model. Ingestion of acetylsalicylic acid (aspirin) by breast cancer patients has been reported to restore the systemic synthesis of maspin through the stimulation of systemic nitric oxide production. Studies were carried out to determine the effect of aspirin on the incidence of breast cancer metastasis, which is reported to occur in 50% of patients who have previously received chemotherapy, radiation, and ⁄ or surgery. Thirty-five female patients (aged 41-65 years) with breast cancer who had previously received these therapies took one 75 mg ⁄ 70 kg body weight enteric-coated aspirin tablet every 24 h, after an adequate meal, for 3 years. Their plasma nitric oxide and maspin levels were measured. The occurrence of metastasis was ascertained monthly by a qualified oncologist, and confirmed, if necessary, by biopsy. Daily ingestion of aspirin by participants resulted in an increase in maspin levels from 0.95 ± 0.04 to 4.63 ± 0.05 nM after 24 h. These levels were maintained for 3 years. These studies suggest that daily ingestion of aspirin might significantly reduce the incidence of breast cancer metastasis in patients who have previously received anticancer therapies. (Cancer Sci 2010; 101: 2105-2109 M ammary serpin (maspin), a serine proteinase inhibitor, has been reported to prevent ⁄ control breast cancer.( 1) This protein (42 kDa) is reported to be synthesized abundantly in normal mammary epithelial cells through the expression of maspin mRNA.(2,3) However, the synthesis of the protein is reported to progressively decrease with the progression of breast cancer.(2,3) Exogenously administered maspin in an animal model has been shown to reduce the growth and metastasis of breast cancer as well as to block tumor motility and invasion, (4,5) and the effect of maspin was reported to be reversed by the use of antimaspin antibody.(6) Considering the anticancer properties of maspin, it is possible to suggest that the protein plays a critically important role in the prevention of metastasis as well as in the development of breast cancer.It has been reported that the synthesis of this protein under physiological conditions is regulated by insulin-induced nitric oxide (NO) synthesis, and the impaired maspin synthesis in breast cancer (2,3) was related to the impairment of insulinreceptor interaction in the malignant cells, leading to impaired NO synthesis.(7) Maspin production in human breast cancer can be restored to normal ranges by using aspirin, which stimulates NO synthesis independently of the insulin receptor both in the case of malignant breast cancer cells in vitro, and in breast cancer patients who ingest the compound orally.(8) This effect of aspirin, resulting in the stimulation of NO synthesis in various cells, has been reported to be independent of the well-known effect of aspirin on the inhibition of prostaglandin synthesis. (9) Breast cancer is well known for its pr...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Acetyl salicyclic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients

et al. 2010

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“…98 Furthermore, the same ethanolic extract of A. hygrometricus was found as a powerful activator of NOS enzyme 23 and it had been formerly reported that nitric oxide synthase (NOS) activation had an inhibitory effect on various types of cancers including Ehrlich's ascites carcinoma. 99,100 This might be an added value on the inhibition of Ehrlich's ascites carcinoma. Heteroglucan, AE2 obtained from A. hygrometricus, exhibited significant antitumor activity.…”

Section: Cardioprotective Activitymentioning

confidence: 99%

A Comprehensive Review on Food and Medicinal Prospects of Astraeus hygrometricus

Biswas

Nandi²,

Kuila³

et al. 2017

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“…The availability of NO at cellular level is critically important in the final outcome of the effect of NO on cancer cells. For example while excess NO can act as a procarcinogenic compound (Iwarkiri et al 2002), the physiological amounts of the same compound can act as a systemic anticancer agent (Kilbourn and Belloni 1990;Sinha et al 2002). We have recently reported that the binding of insulin to its highaffinity receptors on erythrocyte membrane in human breast cancer was impaired which resulted in the impaired synthesis of NO (Chakraborty et al 2004).…”

Section: Introductionmentioning

confidence: 99%

The role of insulin dependent NO synthesis in the impaired production of maspin in human breast cancer

Girish

Bhattacharya

Sinha

2006

J Cancer Res Clin Oncol

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Neutralization by "antineoplastin" of insulin-activated nitric oxide synthase antibody and its effects in cancers

Abstract: It was found that the resumption of NO synthesis through the neutralization of antibody resulted in favorable modifications of various cancer-associated pathophysiologic consequences.

Cited by 10 publications

References 16 publications

Acetyl salicyclic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients

Acetyl salicyclic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients

A Comprehensive Review on Food and Medicinal Prospects of Astraeus hygrometricus

The role of insulin dependent NO synthesis in the impaired production of maspin in human breast cancer

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