Neutral glyceroglucolipids of the human gastric content

Slomiany, Amalia; Slomiany, Bronislaw L.

doi:10.1016/0006-291x(77)91675-8

Cited by 17 publications

(4 citation statements)

References 10 publications

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“…The results presented here together with our earlier studies on glycolipids of gastric secretion [I, 2,23,24] strongly suggest an orderly distribution ofglycoprotein and glycolipid type of ABH antigens, which is in strict agreement with the early observations of Friedenreich and Hartmann [6,7], that alcohol-soluble substances are exclusively present in tissue, whereas water-soluble glycoprotein antigens represent secretory products.…”

supporting

confidence: 92%

“…The fatty acids methyl esters were separated from glyceryl ethers in hexane/diethyl ether/acetic acid (70/30/1, v/v/v). For the analysis of glycerol, a portions of acid methanolysates prior to hexane extraction were dried and treated with BC13 [30] at room temperature for 18 h [23] and analyzed for glycerol by gas-liquid chromatography [31]. Portions of acid methanolysates after removal of fatty acids methyl esters and glyceryl ethers were neutralized with silver carbonate, dried, derivatized with silylating reagent and analyzed for carbohydrates [32].…”

Section: Composition Of the Glycolipidsmentioning

confidence: 99%

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ABH‐Blood‐Group Antigens and Glycolipids of Human Saliva

Slomiany

1978

European Journal of Biochemistry

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The nature of ABH-blood-group antigens in saliva was investigated. Human saliva was examined serologically for ABH-blood-group activity in its native form and after various treatments. The activity of the native form persisted in the delipidated samples, but was entirely lost after alkaline degradation. The lipid portion of saliva was completely inactive in the ABH hemagglutination inhibition system. The same results were obtained when purified glycolipid fraction of saliva was used instead of whole lipid extract. Neither alkaline treatment nor excessive amounts of salivary lipids effected antigenic activity of A-active glycosphingolipids of hog gastric inucosa admixed to saliva samples before alkaline degradation and/or in presence of large amounts of salivary lipids.The isolated glycolipid fractions contained at least eight glycolipids, each of which was composed of glucose, glyceryl ethers and fatty acids and differed from others with respect to number of glucose residues.Sphingosine and sugar residues involved in formation of ABH antigenic determinants were not detected.These findings together with data 011 stomach secretion [1,2] led US to the conclusion that ABHblood-group antigens of saliva are exclusively of glycoprotein nature.The search for the understanding of blood group activity and the nature of tissue antigens has revealed the importance of specific carbohydrate chains. However, the question of what is the nature of bloodgroup-active antigens from secretions and from tissue cells has not been answered.From the work of Schiff, Freudenberg, Torpes, Goebel, Meyer and their many coworkers [3 -51 much useful chemical evidence has been gained about materials with blood group activity and their complexity.The study of Friedenreich and Hartmann [6] and Hartmann [7] revealed a dual nature of blood-groupactive antigens; a water-soluble form found only in body fluids and secretions and an alcohol-soluble form present on tissue cells and erythrocytes.Discovery of blood-group-active antigens of glycosphingolipids and glycoprotein origin from the same source [8 -191 led to the proposal of their coexistence in the tissues and to the assumption [20] that secretions represent also a mixture of blood-group-active glycosphingolipids and glycoproteins. Also, the evidence was presented on the glycoprotein nature of ABH antigens of erythrocytes [21,22] which were known for long time to contain antigens of the glycosphingolipid character. These data created a chaotic picture of the distribution of blood-group-active glycosphingolipids and glycoproteins.The results presented here together with our earlier studies on glycolipids of gastric secretion [I, 2,23,24] strongly suggest an orderly distribution ofglycoprotein and glycolipid type of ABH antigens, which is in strict agreement with the early observations of Friedenreich and Hartmann [6,7], that alcohol-soluble substances are exclusively present in tissue, whereas water-soluble glycoprotein antigens represent secretory products. MATERIALS AND METHODS MaterialsSaliva...

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confidence: 92%

Section: Composition Of the Glycolipidsmentioning

confidence: 99%

ABH‐Blood‐Group Antigens and Glycolipids of Human Saliva

Slomiany

1978

European Journal of Biochemistry

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“…Monoalkyl glycerol ethers are most frequently found as alkyldiacylglycerols (similar to triacylglycerols). However, these compounds, whose occurrence in petrel stomach oils has been reported [9, 10, 31, 32], as well as triglycerides and/or diglycerides, present in large amounts in other previously examined oil samples, were not detected at all in the Mumijo sample investigated. This difference might be ascribed to the age of the sample and, as a consequence, to the effect of a slow lipolysis.…”

Section: Discussionmentioning

confidence: 76%

“…The mineral content of the Antartican Mumijo has not yet been determined, leaving room also for a potential application in the treatment of bone diseases [29]. Likewise the potential biomedical activity of the monoglycerides, known to possess potent antimicrobial/microbicidal activity [30], and of the neutral glyceroglucolipids [31], comprising anti-stomach ache effectiveness, are not addressed here.…”

Section: Discussionmentioning

confidence: 99%

Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)

Aiello

Fattorusso

Menna

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels, Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives. In vitro experiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragment β-fragment 25–35 (Aβ25–35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives.

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Glycoglycerolipids of Animal Tissues

Murray

Narasimhan

1990

Glycolipids, Phosphoglycolipids, and Sulfoglycolipids

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Neutral glyceroglucolipids of the human gastric content

Cited by 17 publications

References 10 publications

ABH‐Blood‐Group Antigens and Glycolipids of Human Saliva

ABH‐Blood‐Group Antigens and Glycolipids of Human Saliva

Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)

Glycoglycerolipids of Animal Tissues

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