Neutral Endopeptidase Determines the Severity of Pancreatitis-Associated Lung Injury1

Ischemia postconditioning preventing lung ischemia–reperfusion injury

“…The activity of MPO was used as a marker of neutrophil infiltration (Bradley et al, 1982;Day et al, 2005;Sener et al, 2005). Lung MPO activity was determined as described previously (Serafin et al, 2002).…”

HJP272, A Novel Endothelin Receptor Antagonist, Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Hamsters

“…Despite the greater efficacy of phosphoramidon, the therapeutic potential of this agent may be limited by the fact that it also has an inhibitory effect on various metalloproteinases which have anti-inflammatory activity [23][24][25]. This finding suggests that phosphoramidon would require extensive clinical testing for potential adverse reactions prior to evaluation of its efficacy as a treatment for inflammatory disorders.…”

Clinical relevance of Neutral Endopeptidase (NEP/CD10) in melanoma

“…Altered NEP expression has been shown to play a role in many non-neoplastic [1-3] and neoplastic disaeases [4-8]. In many tumors, such as prostate and small-cell lung cancer, NEP is thought to act as a tumor suppressor, as its expression is down-regulated with tumor progression [4,5].…”