Neutral diterpenoids of oleoresins of five species of conifers of Transcarpathia

Bol'shakova, V. I.; Demenkova, L. I.; Shmidt, E. N.; Pentegova, V. A.

doi:10.1007/bf00598185

Cited by 3 publications

(2 citation statements)

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“…Those already described for L. decidua were mainly found in the bark, needle and wood samples only. The reported ones for the oleoresin were only 13-epimanool (70) ( Norin, 1972 ; Mills, 1973 ; Norin and Winell, 1974 ; Bol'shakova et al., 2004 ; Salem et al., 2015 ; Thuerig et al., 2018 ; Dietemann et al., 2019 ), isopimarinal (71) ( Bol'shakova et al., 2004 ; Bajer et al., 2020 ), and palustrinal (72) ( Bol'shakova et al., 2004 ; Holmbom et al., 2008 ). In conclusion, all classes of volatile compounds were present in our samples.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS

Batista,

Melo,

Holandino

et al. 2024

Front. Plant Sci.

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IntroductionLarch oleoresin has been described regarding several biological activities and medicinal applications, such as wound healing and treatment of ulcers, but little is known about its chemical composition.Material and methodsEight oleoresins from Larix decidua Mill. obtained from four companies and one adulterated control were therefore investigated to determine their content of essential oils and to verify possible differences in their composition in relation to the harvest and manufacturing processes. Essential oils (EOs) were isolated by distillation and the yield was analysed.Results and discussionThe yield of EO varied among all samples. The yield of the pure larch samples covered a range of 7.8% to 15.5%. A higher yield (19.0%) was observed for adulterated control, which contained oleoresins from different Pinaceae trees. Age of samples had no impact on yield. However, there was a significant statistical variation (p<0.05) in the yields of the mid-summer oleoresins (>10%) compared to early or late summer (<10%), emphasising the importance of the time of collection. Samples were subsequently analysed by GC-MS. EO samples confirmed the presence of various chemical classes, such as monoterpenes, sesquiterpenes, and diterpenes. α-pinene was the compound with the highest concentrations (>50%), followed by β-pinene (>6%), D-limonene (>2.5%), α-terpineol (>0.9%), β-myrcene (>0.2%), and 3-carene (>0.05%). Samples were grouped using multivariate data analysis (MVDA) with respect to the chemical variation between the oleoresins’ EOs. The resulting four clusters were named low (low yield obtained for the samples), mixed (mixed oleoresin from different Pinaceae species, adulteration control), old (old oleoresin kept in the institute), and normal (other oleoresins) samples, each presenting distinct chemical biomarkers. There were considerable differences between site and time of collection. Essential oil yield did not always meet requirements as defined by the German Homeopathic Pharmacopoeia. In addition, adulterated or aged samples could be identified as compared to pure and fresh larch oleoresins.ConclusionWe conclude that larch oleoresin used for pharmaceutical applications has to be carefully analysed and standardised to guarantee reproducible product quality.

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Section: Resultsmentioning

confidence: 99%

Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS

Batista,

Melo,

Holandino

et al. 2024

Front. Plant Sci.

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“…Larixyl acetate is one of the most described diterpenoid present in L. decidua in the bark (Mulholland et al, 2017;Thuerig et al, 2018), wood (Pferschy-Wenzig et al, 2008Thuerig et al, 2018), and resin (Norin, 1972;Mills, 1973;Bol'shakova et al, 1988;Dietemann et al, 2019). Antimicrobial activity of the isolated larixyl acetate was demonstrated against P. viticola, with MIC 100 of 6 μg/ml (Thuerig et al, 2018) and an efficacy of 100% at 1 mg/ ml (Mulholland et al, 2017).…”

Section: Antimicrobial Effects Of Resin Are Often Attributed To the A...mentioning

confidence: 98%

A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds

et al. 2022

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Malignant ulcerating wounds or neoplastic lesions are a considerable burden for patients suffering from advanced cancer. These wounds have no effective treatment and are very difficult to manage. The present review summarizes evidence in support of a hypothesis put forward in anthroposophic medicine, which suggests a beneficial role of resin from the species Larix decidua Mill. [Pinaceae] for treating such wounds. A systematic search strategy was performed using the databases PubMed, EMBASE and SciFinder. The included publications described the chemical composition of this species, as well as in vitro, in vivo, and ex vivo experiments using plant extracts and isolated compounds. The results show that among the phytochemical classes, terpenoids were the major components of this species, especially in the resin. The summarized biological experiments revealed antimicrobial, antioxidant and anti-inflammatory effects, with promising potential for the extracts and isolated compounds. However, the molecular mechanisms and toxicological effects are as of yet not conclusively evaluated. From the data of our study, we can conclude that L. decidua might indeed have a promising potential for the treatment of malignant wounds, but definitive information that can prove its effectiveness is still lacking. We therefore suggest that future efforts should be dedicated to the evaluation of L. decidua resin's therapeutic use considering its antiseptic action and proposed wound healing properties.

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(+)-Larixol and Larixyl Acetate: Syntheses, Phytochemical Studies and Biological Activity Assessments

Ciocârlan¹

2021

ChemJMold

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Neutral diterpenoids of oleoresins of five species of conifers of Transcarpathia

Cited by 3 publications

References 1 publication

Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS

Characterization of Larix decidua Mill. (Pinaceae) oleoresin’s essential oils composition using GC-MS

A Scoping Review on the Therapeutic Potential of Resin From the Species Larix decidua Mill. [Pinaceae] to Treat Ulcerating Wounds

(+)-Larixol and Larixyl Acetate: Syntheses, Phytochemical Studies and Biological Activity Assessments

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