Neutral atom beam technique enhances bioactivity of PEEK

Khoury, Joseph T.; Kirkpatrick, Sean; Maxwell, Melissa; Cherian, Raymond E.; Kirkpatrick, A. R.; Svrluga, R.

doi:10.1016/j.nimb.2012.11.087

Cited by 47 publications

(32 citation statements)

References 34 publications

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“…The authors explained that the increased biocompatibility was related to the surface nanometer texture, which enhanced cell attachment and proliferation. 45 The results from this study correspond to the finding that nanoscale surface modification enhances RTQ and wettability, which together enhance the biocompatibility of PEEK. The numerical data on the micrometer level as evaluated with an interferometer revealed more dense peaks on the surface of the control group samples.…”

supporting

confidence: 87%

Biomechanical evaluation and surface characterization of a nano-modified surface on PEEK implants: a study in the rabbit tibia

Johansson¹,

Jimbo²,

Kjellin³

et al. 2014

IJN

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Polyether ether ketone (PEEK) is today frequently used as a biomaterial in different medical operations due to its excellent mechanical and chemical properties. However, the untreated surface of PEEK is bioinert and hydrophobic, and it does not osseointegrate in its pure form. The aim of this study was to evaluate a unique nano-modified surface of PEEK with respect to osseointegration. Forty-eight threaded, non-cutting PEEK implants were inserted bilaterally in the tibia of 24 rabbits. Half of the implants (n=24) were coated with nanocrystalline hydroxyapatite (test) and the remaining implants (n=24) were left uncoated (control). Half of the animals (n=12) were euthanized after 3 weeks of healing and the remaining (n=12) after 12 weeks. The implant retention was measured with a removal torque apparatus. Surface analysis was performed with interferometry, scanning electron microscopy, and X-ray photon spectroscopy to relate the removal torque to the applied surface. The test implants revealed a significantly higher retention after 3 weeks ( P =0.05) and 12 weeks ( P =0.028) compared to controls. The result of the present study proves that the addition of nanocrystalline hydroxyapatite coating to PEEK surfaces significantly increases its removal torque and biocompatibility.

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supporting

confidence: 87%

Biomechanical evaluation and surface characterization of a nano-modified surface on PEEK implants: a study in the rabbit tibia

Johansson¹,

Jimbo²,

Kjellin³

et al. 2014

IJN

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“…Khoury et al [34] employed the ANAB technique to enhance the surface bioactivity of PEEK without modification of surface chemistry and without the addition of bioactive substances. In vitro experiments demonstrated that the ANAB-treated PEEK fostered enhanced growth of human fetal osteoblast cells (hFOB) compared with untreated PEEK as evidenced by cell proliferation assays and microscopy.…”

Section: Surface Modificationmentioning

confidence: 99%

Current Strategies to Improve the Bioactivity of PEEK

Tang

2014

IJMS

383

296

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The synthetic thermoplastic polymer polyetheretherketone (PEEK) is becoming a popular component of clinical orthopedic and spinal applications, but its practical use suffers from several limitations. Although PEEK is biocompatible, chemically stable, radiolucent and has an elastic modulus similar to that of normal human bone, it is biologically inert, preventing good integration with adjacent bone tissues upon implantation. Recent efforts have focused on increasing the bioactivity of PEEK to improve the bone-implant interface. Two main strategies have been used to overcome the inert character of PEEK. One approach is surface modification to activate PEEK through surface treatment alone or in combination with a surface coating. Another strategy is to prepare bioactive PEEK composites by impregnating bioactive materials into PEEK substrate. Researchers believe that modified bioactive PEEK will have a wide range of orthopedic applications.

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“…Surface modification through physical or chemical techniques can increase surface energies and encourage binding of biological molecules [8–10]. The development of PEEK composite materials has also shown potential for increasing bioactivity [11,12].…”

Section: Introductionmentioning

confidence: 99%

Deposition, heat treatment and characterization of two layer bioactive coatings on cylindrical PEEK

Durham

Rabiei

2016

Surface and Coatings Technology

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Polyether ether ketone (PEEK) rods were coated via ion beam asssited deposition (IBAD) at room temperature. The coating consists of a two-layer design of yttria-stabilized zirconia (YSZ) as a heat-protection layer, and hydroxyapatite (HA) as a top layer to increase bioactivity. A rotating substrate holder was designed to deposit an even coating on the cylindrical surface of PEEK rods; the uniformity is verified by cross-sectional measurements using scanning electron microscopy (SEM). Deposition is followed by heat treatment of the coating using microwave annealing and autoclaving. Transmission electron microscopy (TEM) showed a dense, uniform columnar grain structure in the YSZ layer that is well bonded to the PEEK substrate, while the calcium phosphate layer was amorphous and pore-free in its as-deposited state. Subsequent heat treatment via microwave energy introduced HA crystallization in the calcium phosphate layer and additional autoclaving further expanded the crystallization of the HA layer. Chemical composition evaluation of the coating indicated the Ca/P ratios of the HA layer to be near that of stoichiometric HA, with minor variations through the HA layer thickness. The adhesion strength of as-deposited HA/YSZ coatings on smooth, polished PEEK surfaces was mostly unaffected by microwave heat treatment, but decreased with additional autoclave treatment. Increasing surface roughness showed improvement of bond strength.

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Neutral atom beam technique enhances bioactivity of PEEK

Cited by 47 publications

References 34 publications

Biomechanical evaluation and surface characterization of a nano-modified surface on PEEK implants: a study in the rabbit tibia

Biomechanical evaluation and surface characterization of a nano-modified surface on PEEK implants: a study in the rabbit tibia

Current Strategies to Improve the Bioactivity of PEEK

Deposition, heat treatment and characterization of two layer bioactive coatings on cylindrical PEEK

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