Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation
Salil R. Rajayer,
Stephen M. Smith
Abstract:Background
Neurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus clearance. Detailed understanding of the underlying changes in brain function may facilitate the identification of therapeutic targets. We directly tested how neocortical function is impacted by the specific panel of cytokines that occur in coronavirus brain infection. Using the whole-cell patch-clamp technique, we determined how the five cytokines (TNF… Show more
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