Neurovascular toxicity of N-methyl-d-aspartate is markedly enhanced in the developing mouse central nervous system

Vadivelu, Sudhakar; Xu, Kui; Tolj, Vanja; Rege, Rahul; Darkins, Lindsay; Vishwanath, Karthik

doi:10.1016/j.neulet.2017.06.027

Cited by 2 publications

(6 citation statements)

References 24 publications

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“…We have previously employed fiber-based diffuse reflectance spectroscopy (DRS) systems operating at short source–detector geometries to quantify functional properties in skin tissues in vivo . 25 – 27 We have also previously reported preliminary findings from our use of DRS in pediatric patients implanted with VP shunts for hydrocephalus with or without shuntodynia. 28 Here we extend our analysis to be statistically robust and examine if patient reported shuntodynia was detectable using optically derived, quantitative hemodynamic signatures obtained in skin-tissues adjacent to VP implants in subjects during a single clinical visit.…”

Section: Introductionmentioning

confidence: 90%

“…DRS measurements were obtained using a fiber spectroscopy system described previously 25 , 28 . The system was constructed by coupling a broadband tungsten–halogen light source (HL2000, Ocean Optics, Florida, United States) to the tissue using a bifurcated optical fiber with core size 600 μm and collecting the diffuse reflectance at a distance of ∼600 μm from the source, with an identical fiber (BIF600-UV-VIS, Ocean Optics, Florida, United States).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients?

Kline,

Vishwanath,

Colbrunn

et al. 2024

J. Biomed. Opt.

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Shuntodynia is patient reported pain at the site of the implanted ventriculoperitoneal (VP) shunt. Pediatric hydrocephalus requiring shunt placement is a chronic and prevalent standard of care treatment and requires lifetime management. Shuntodynia is a subjective measure of shunt dysfunction. Quantitative, white-light tissue spectroscopy could be used to objectively identify this condition in the clinic.Aim: Pediatric subjects were recruited for optical sensing during routine clinical follow-up visits, post-VP shunt implantations. Acquired optical signals were translated into skin-hemodynamic signatures and were compared between subjects that reported shuntodynia versus those that did not.Approach: Diffuse reflectance spectroscopy (DRS) measurements were collected between 450 and 700 nm using a single-channel fiber-optical probe from (N ¼ 35) patients. Multiple reflectance spectra were obtained by the attending physician from regions both proximal and distal to the VP shunt sites and from a matched contralateral site for each subject. Acquired reflectance spectra were processed quantitatively into functional tissue optical endpoints. A two-way, repeated measures analysis of variance was used to assess whether and which of the optical variables were statistically separable, across subjects with shuntodynia versus those without.Results: Analyses indicated that intrapatient differences in vascular oxygen saturation measured between shunt sites relative to that obtained at the scar or contralateral sites was significantly lower in the pain group. We also find that the total hemoglobin concentrations at the shunt site were lowest relative to the other sites for subjects reporting pain. These findings suggest that shuntodynia pain arises in the scalp tissue around the implanted shunts and may be caused due to hypoxia and inflammation.Conclusions: Optically derived hemodynamic variables were statistically significantly different in subjects presenting with shuntodynia relative to those without. DRS could provide a viable mode in routine bedside monitoring of subjects with VP shunts for clinical management and assessment of shuntodynia.

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Section: Introductionmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients?

Kline,

Vishwanath,

Colbrunn

et al. 2024

J. Biomed. Opt.

Self Cite

View full text Add to dashboard Cite

show abstract

“…DRS measurements were obtained using a fiber spectroscopy system described previously 25, 28 . The system was constructed by coupling a broadband tungsten-halogen light source (HL2000, Ocean Optics, FL) to the tissue using a bifurcated optical fiber with core size 600 μm and collecting the diffuse reflectance at a distance of approximately 600 μm from the source, with an identical fiber (BIF600-UV-VIS, Ocean Optics, FL).…”

Section: Methodsmentioning

confidence: 99%

“…Again, to the best of our knowledge no previous diffuse optical studies have examined optically derived functional changes in skin tissues. We have previously employed fiber-based diffuse reflectance spectroscopy (DRS) systems operating at short source-detector geometries to quantify functional properties in skin tissues in vivo 25-27 . We have also previously reported preliminary findings from our use of DRS in pediatric patients implanted with VP shunts for hydrocephalus with or without shuntodynia 28 .…”

Section: Introductionmentioning

confidence: 99%

Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients?

Kline,

Vishwanath,

Colbrunn

et al. 2023

Preprint

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Significance: Shuntodynia is patient reported pain at the site of the implanted ventriculo-peritoneal (VP) shunt. Pediatric hydrocephalus requiring shunt placement is a chronic and prevalent standard of care treatment and requiring lifetime management. Shuntodynia is a subjective measure of shunt dysfunction. Quantitative, white-light tissue spectroscopy could be used to objectively identify this condition in the clinic. Aim: Pediatric subjects were recruited for optical sensing during routine clinical follow-up visits, post VP shunt implantations. Acquired optical signals were translated into skin-hemodynamic signatures and were compared between subjects that reported shuntodynia vs. those that did not. Approach: Diffuse reflectance spectroscopy (DRS) measurements were collected between 450-700 nm using a single-channel fiber-optical probe from (N=35) patients. Multiple reflectance spectra were obtained by the attending physician from regions both proximal and distal to the VP shunt sites, and from a matched contralateral site for each subject. Acquired reflectance spectra were processed quantitatively into functional tissue optical endpoints. A two-way, repeated measures analysis of variance (ANOVA) was used to assess whether and which of the optical variables were statistically separable, across subjects with shuntodynia vs. those without. Results: Results showed that vascular oxygen saturation was significantly lower in subjects reporting shuntodynia, when measured proximal to shunt sites. Subjects with shuntodynia also had lower total hemoglobin at the shunt site relative to distal sites. Both patient groups showed higher tissue scattering at the shunt sites in comparison to the contralateral sites. Conclusions: Optically derived hemodynamic variables were statistically significantly different in subjects presenting with shuntodynia relative to those without. DRS could provide a viable mode in routine bedside monitoring of subjects with VP shunts for clinical management and risk assessment of shuntodynia.

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Neurovascular toxicity of N-methyl-d-aspartate is markedly enhanced in the developing mouse central nervous system

Cited by 2 publications

References 24 publications

Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients?

Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients?

Can diffuse reflectance spectroscopy identify shuntodynia in pediatric hydrocephalus patients?

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