2012
DOI: 10.1016/j.eururo.2012.04.057
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Neurovascular Structure-adjacent Frozen-section Examination (NeuroSAFE) Increases Nerve-sparing Frequency and Reduces Positive Surgical Margins in Open and Robot-assisted Laparoscopic Radical Prostatectomy: Experience After 11 069 Consecutive Patients

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Cited by 221 publications
(214 citation statements)
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References 31 publications
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“…In contrast, no such tradeoff is required with the multiscale NLM approach presented here because NLM enables thin axial sectioning of fresh tissue. Furthermore, a large study of FSA margin evaluation in nerve sparing prostatectomy reported substantial improvements in rates of nerve sparing surgeries, but required 5 cryostats and 4 histotechs working in parallel to evaluate 10 to 24 specimens per patient in an average of 35 minutes [54]. In contrast, multiscale NLM scales much more favorably with increasing numbers of bread loaf specimens, because after inking and grossing, multiple bread loaf specimens can be stained simultaneously and then examined without physical sectioning as shown in Figs.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, no such tradeoff is required with the multiscale NLM approach presented here because NLM enables thin axial sectioning of fresh tissue. Furthermore, a large study of FSA margin evaluation in nerve sparing prostatectomy reported substantial improvements in rates of nerve sparing surgeries, but required 5 cryostats and 4 histotechs working in parallel to evaluate 10 to 24 specimens per patient in an average of 35 minutes [54]. In contrast, multiscale NLM scales much more favorably with increasing numbers of bread loaf specimens, because after inking and grossing, multiple bread loaf specimens can be stained simultaneously and then examined without physical sectioning as shown in Figs.…”
Section: Discussionmentioning
confidence: 99%
“…14,15 The tissue microarray manufacturing process was described earlier in detail. 16 In short, one 0.6 mm core was taken from a representative tissue block from each patient.…”
Section: Patientsmentioning
confidence: 99%
“…Since the introduction of a neurovascular structure-adjacent frozen-section examination (NeuroSAFE) in our institution, most RPs were performed using a NS approach with secondary resection of the NVBs in case of positive frozen section [7].…”
Section: Introductionmentioning
confidence: 99%