Neurovascular development

Bautch, Victoria L.; James, Jennifer M.

doi:10.4161/cam.3.2.8397

Cited by 78 publications

(31 citation statements)

References 54 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Initial CNS vascularization occurs through invading, sprouting angiogenesis (branching of existing vessels) that originates from a juxtaposed, mesoderm-derived perineural vascu- lar plexus located outside the CNS 19 . As endothelial cells penetrate the embryonic neural tube and migrate through the neuropil toward the ventricles, they secrete molecular cues that recruit pericytes to the nascent capillary tube.…”

Section: Origin Of Cns Pericytesmentioning

confidence: 99%

Central nervous system pericytes in health and disease

2011

View full text Add to dashboard Cite

Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators, coordinators and effectors of many neurovascular functions, including angiogenesis, blood-brain barrier (BBB) formation and maintenance, vascular stability and angioarchitecture, regulation of capillary blood flow and clearance of toxic cellular byproducts necessary for proper CNS homeostasis and neuronal function. New studies have revealed that pericyte deficiency in the CNS leads to BBB breakdown and brain hypoperfusion resulting in secondary neurodegenerative changes. Here we review recent progress in understanding the biology of CNS pericytes and their role in health and disease.

show abstract

Section: Origin Of Cns Pericytesmentioning

confidence: 99%

Central nervous system pericytes in health and disease

2011

View full text Add to dashboard Cite

show abstract

“…Classic theories have documented the formation of the vascular plexus surrounding the embryonic brain and spinal cord, and the subsequent ingression of vascular into the neural tissue (Bautch and James, 2009; Nakao et al , 1988). To date, a growing body of evidence indicates that the genetic programs previously described to control the growth of nerve cells also guide the vascular development (Vogel, 2005).…”

Section: Microrna and The Development Of The Brainmentioning

confidence: 99%

“…The neurovascular cross-talk is initiated in the early stage of embryonic development and lasts throughout the life. For example, in the mouse the blood-brain barrier is functional at E15.5 (Ben-Zvi et al , 2014) and protects the fragile CNS tissue from metabolic and cellular changes (Bautch and James, 2009). Neurovascular coupling is developed to undertake important physiological functions, such as the regulation of cerebral blood flow (CBF) in response to local neural activities, and its abnormality implicates various brain diseases, such as cerebral cavernous malformations and vascular dementia (Attwell et al , 2010; Iadecola, 2004).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic programming of hypoxic–ischemic encephalopathy in response to fetal hypoxia

Zhang

2015

Progress in Neurobiology

View full text Add to dashboard Cite

Hypoxia is a major stress to the fetal development and may result in irreversible injury in the developing brain, increased risk of central nervous system (CNS) malformations in the neonatal brain and long-term neurological complications in offspring. Current evidence indicates that epigenetic mechanisms may contribute to the development of hypoxic/ischemic-sensitive phenotype in the developing brain in response to fetal stress. However, the causative cellular and molecular mechanisms remain elusive. In the present review, we summarize the recent findings of epigenetic mechanisms in the development of the brain and their roles in fetal hypoxia-induced brain developmental malformations. Specifically, we focus on DNA methylation and active demethylation, histone modifications and microRNAs in the regulation of neuronal and vascular developmental plasticity, which may play a role in fetal stress-induced epigenetic programming of hypoxic/ischemic-sensitive phenotype in the developing brain.

show abstract

“…An emerging focus in both neurodevelopment and neurodegenerative disease is the “neurovascular link”: that is, the recognition of extensive intercellular signaling between blood vessels, in particular, ECs and neurons, axons, and glia (41–47). The close congruency of blood vessel and peripheral nerve growth is well documented (45, 46, 48), and numerous studies have shown that the developing vascular and peripheral nervous systems share guidance cues (49–51).…”

Section: Introductionmentioning

confidence: 99%

“…Neurons and endothelial cells share additional molecular pathways including Ephrins/Ephs; Nrpns/Semas/Plexins, Netrins, Notch/Delta, Slit/Robo, and SDF-1/CXCR4 (10, 66–73). In the CNS, these bidirectional interactions are such that they comprise a “neurovascular unit” that includes neurons, glia, pericytes, and ECs, and this ensemble provides a critical stem cell niche in which mitotically active neural progenitors are found in close proximity to blood vessels (41, 74). Crosstalk between the two systems promotes the survival and maintenance of neurons and ECs and in fact, the neural degeneration that is the hallmark of many neurological diseases (e.g.…”

Section: Introductionmentioning

confidence: 99%

In vivo time-lapse imaging reveals extensive neural crest and endothelial cell interactions during neural crest migration and formation of the dorsal root and sympathetic ganglia

George

Dunkel

Hunnicutt

et al. 2016

Developmental Biology

View full text Add to dashboard Cite

During amniote embryogenesis the nervous and vascular systems interact in a process that significantly affects the respective morphogenesis of each network by forming a “neurovascular” link. The importance of neurovascular cross-talk in the central nervous system has recently come into focus with the growing awareness that these two systems interact extensively both during development, in the stem-cell niche, and in neurodegenerative conditions such as Alzheimer’s Disease and Amyotrophic Lateral Sclerosis. With respect to the peripheral nervous system, however, there have been no live, real-time investigations of the potential relationship between these two developing systems. To address this deficit, we used multispectral 4D time-lapse imaging in a transgenic quail model in which endothelial cells (ECs) express a yellow fluorescent marker, while neural crest cells (NCCs) express an electroporated red fluorescent marker. We monitored EC and NCC migration in real-time during formation of the peripheral nervous system. Our time-lapse recordings indicate that NCCs and ECs are physically juxtaposed and dynamically interact at multiple locations along their trajectories. These interactions are stereotypical and occur at precise anatomical locations along the NCC migratory pathway. NCCs migrate alongside the posterior surface of developing intersomitic vessels, but fail to cross these continuous streams of motile ECs. NCCs change their morphology and migration trajectory when they encounter gaps in the developing vasculature. Within the nascent dorsal root ganglion, proximity to ECs causes filopodial retraction which curtails forward persistence of NCC motility. Overall, our time-lapse recordings support the conclusion that primary vascular networks substantially influence the distribution and migratory behavior of NCCs and the patterned formation of dorsal root and sympathetic ganglia.

show abstract

Neurovascular development

Cited by 78 publications

References 54 publications

Central nervous system pericytes in health and disease

Central nervous system pericytes in health and disease

Epigenetic programming of hypoxic–ischemic encephalopathy in response to fetal hypoxia

In vivo time-lapse imaging reveals extensive neural crest and endothelial cell interactions during neural crest migration and formation of the dorsal root and sympathetic ganglia

Contact Info

Product

Resources

About