Neurovascular Coupling in the Dentate Gyrus Regulates Adult Hippocampal Neurogenesis

Shen, Jia; Wang, Depeng; Wang, Xinxing; Gupta, Shashank; Ayloo, Bhargav; Wu, Song; Prasad, Paras N.; Xiong, Qiaojie; Xia, Jun; Ge, Shaoyu

doi:10.1016/j.neuron.2019.05.045

Cited by 52 publications

(47 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We next recorded neuronal activity of the primary auditory cortex from well-trained mice using in vivo Ca 2+ imaging. We expressed GCaMP6f, an ultrasensitive Ca 2+ sensor protein [7], in the primary auditory cortex by the stereotaxic injection of adeno-associated virus (AAV) and then implanted a prism lens above the injection site for Ca 2+ imaging using miniaturized fluorescence microscopy, as described previously [12, 24] (Fig. 2a & b).…”

Section: Resultsmentioning

confidence: 99%

Cortical ensemble activity discriminates auditory attentional states

et al. 2019

Self Cite

View full text Add to dashboard Cite

Selective attention modulates sensory cortical activity. It remains unclear how auditory cortical activity represents stimuli that differ behaviorally. We designed a cross-modality task in which mice made decisions to obtain rewards based on attended visual or auditory stimuli. We recorded auditory cortical activity in behaving mice attending to, ignoring, or passively hearing auditory stimuli. Engaging in the task bidirectionally modulates neuronal responses to the auditory stimuli in both the attended and ignored conditions compared to passive hearing. Neuronal ensemble activity in response to stimuli under attended, ignored and passive conditions are readily distinguishable. Furthermore, ensemble activity under attended and ignored conditions are in closer states compared to passive condition, and they share a component of attentional modulation which drives them to the same direction in the population activity space. Our findings suggest that the ignored condition is very different from the passive condition, and the auditory cortical sensory processing under ignored, attended and passive conditions are modulated differently.

show abstract

Section: Resultsmentioning

confidence: 99%

Cortical ensemble activity discriminates auditory attentional states

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Enhanced VEGF/VEGFR signaling may contribute to attenuating cognitive deficits after epileptic seizures by promoting adult neurogenesis in the dentate gyrus (Rosenstein et al, 2010;Han et al, 2017). The relationship between adult neurogenesis and the NVU has been studied (Goldman and Chen, 2011), and a recent study reported that microvascular hemodynamics modulate adult neurogenesis (Shen et al, 2019). Furthermore, VEGF administration suppressed neuronal loss in the hippocampal CA1 region 24 h but not one month after pilocarpine-induced SE in rats (Nicoletti et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Vascular Abnormalities and the Role of Vascular Endothelial Growth Factor in the Epileptic Brain

2020

View full text Add to dashboard Cite

Epilepsy is a chronic neurological disorder generally defined to be caused by excessive neuronal activity. Thus, excessive neuronal activity is the main target of the currently used antiepileptic drugs (AEDs). However, as many as 30% of epileptic patients show drug resistance to currently available AEDs, which suggests that epilepsy should be attributed not only to neuronal cells but also to other brain cells, such as glial cells and vascular cells. Astrocytes, pericytes, and endothelial cells in particular comprise the blood-brain barrier (BBB), which tightly regulates the exchange of substances between the brain parenchyma and the circulating blood. It has been proposed that BBB dysfunction, especially barrier leakage, exacerbates epileptic progression, and conversely, that epileptic seizures induce barrier leakage. Furthermore, several studies have shown that BBB dysfunction is one of the main causes of drug resistance in epilepsy. To better understand the mechanisms that link BBB dysfunction and intractable epilepsy to gain insights for the future development of treatments, we review and discuss the relationships between epilepsy and brain vascular abnormalities, mainly by focusing on vascular malformation, BBB dysfunction, and excessive angiogenesis. Because these abnormalities have been reported to be caused by vascular endothelial growth factor (VEGF) in the ischemic brain, we discuss the possible role of VEGF in vascular abnormalities in the epileptic brain, in which the upregulation of VEGF levels has been reported. Both glial cells and endothelial cells express VEGF receptors (VEGFRs); thus, these cells are likely affected by increases in VEGF during seizures, which in turn could cause vascular abnormalities. In this review, we review the possible role of VEGF in epilepsy and discuss the mechanisms that link vascular abnormalities and intractable epilepsy.

show abstract

“…The authors proved that this effect is mediated by parvalbumin-expressing neurons which increase blood flow via nitric-oxide signaling. This increase in the microvascular hemodynamics enhances IGF-1 signaling promoting the newborn cell survival ( Shen et al, 2019 ).…”

Section: Cellular Components Of the Hippocampal Neurogenic Nichementioning

confidence: 99%

Deciphering New Players in the Neurogenic Adult Hippocampal Niche

Bonafina

Paratcha

Ledda

2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

In the mammalian adult hippocampus, new neurons are continuously generated throughout life in the subgranular zone of the dentate gyrus. Increasing evidence point out the contribution of adult-born hippocampal granule cells (GCs) to cognitive processes such as learning and memory, indicating the relevance of understanding the molecular mechanisms that control the development of these new neurons in the preexisting hippocampal circuits. Cell proliferation and functional integration of adult-born GCs is a process highly regulated by different intrinsic and extrinsic factors. In this review, we discuss recent advances related with cellular components and extrinsic signals of the hippocampal neurogenic niche that support and modulate neurogenesis under physiological conditions.

show abstract

Neurovascular Coupling in the Dentate Gyrus Regulates Adult Hippocampal Neurogenesis

Cited by 52 publications

References 60 publications

Cortical ensemble activity discriminates auditory attentional states

Cortical ensemble activity discriminates auditory attentional states

Vascular Abnormalities and the Role of Vascular Endothelial Growth Factor in the Epileptic Brain

Deciphering New Players in the Neurogenic Adult Hippocampal Niche

Contact Info

Product

Resources

About