Neurotrophins: Roles in Neuronal Development and Function

Huang, Eric J.; Reichardt, Louis F.

doi:10.1146/annurev.neuro.24.1.677

Cited by 3,736 publications

(2,823 citation statements)

References 332 publications

(368 reference statements)

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“…p75 NTR has been previously detected in the nerves 13,14,[11][12][13][14][15][16][17][18][19][20][21][22][23] and vessels. 13,14 Although we did not observe significant p75 NTR expression in the fibroblast in normal breast stroma and in the stroma around the carcinoma, we found strong p75 NTR expression in the fibroblasts of the expanding intralobular stroma (fibroadenomatoid change).…”

Section: Discussionmentioning

confidence: 92%

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Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells

et al. 2005

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We evaluated the low affinity neurotrophin receptor (p75 NTR ) as a marker of breast myoepithelial cells. Immunohistochemical staining for p75 NTR was performed on paraffin sections of 122 malignant breast lesions, 28 benign lesions and the adjacent normal breast tissue. The staining pattern was compared to those of myosin heavy chain and p63. p75 NTR immunostain was consistently positive and compatible with p63 and myosin immunoreactivity in the myoepithelial cells of the normal mammary gland, benign breast lesions (six usual ductal hyperplasias, six specimens with sclerosing adenosis, eight intraductal papillomas, six fibroadenomas), and carcinoma in situ (18 ductal carcinomas in situ, two noninvasive papillary carcinomas, two lobular carcinomas in situ). The luminal cells were negative for p75 NTR , but rare positive cells were noticed in the solid areas of some of the usual ductal hyperplasias. Four of 64 invasive ductal carcinomas (6%) and all metaplastic carcinomas (n ¼ 3, 100%) showed a variable degree of p75 NTR positivity. No p75 NTR expression was found in the malignant cells in all in situ carcinomas, invasive lobular carcinomas (n ¼ 11), tubular carcinomas (n ¼ 10), invasive papillary carcinomas (n ¼ 6), mucinous carcinomas (n ¼ 4), and medullary carcinomas (n ¼ 2). No myosin imunoreactivity was seen in the luminal/tumor cells, but p63 pattern of staining in the luminal/tumor cells was quite similar to that of p75 NTR . Although significant p75 NTR immunoreactivity was noticed in the vessels, nerves, and stromal component of fibroadenomas, no difficulties in the evaluation of the immunostain of myoepithelial cells were encountered. Our study shows that p75 NTR is a useful marker for breast myoepithelial cells and can be used to rule out invasive disease as well as to evaluate difficult for diagnosis sclerosing lesions. Our data suggest a role of neurotrophins in the development of fibroepithelial breast tumors and some of the breast carcinomas. Modern Pathology (2005) 18, 1535-1541.

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Section: Discussionmentioning

confidence: 92%

“…11 In addition, they also elicit a wide range of responses in certain non-neural tissues. 12 Neurotrophins' effects are initiated by interactions with specific receptors with low or high affinity (Huang et al 11 and references herein). p75 NTR is a transmembrane glycoprotein member of the TNF-receptor superfamily.…”

mentioning

confidence: 99%

Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells

et al. 2005

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“…Initially isolated as a secretory protein capable of promoting the survival of peripheral neurons, BDNF is now recognized as a plethoric factor able to regulate a wide repertoire of functions, including neuronal survival, migration, phenotypic differentiation, axonal and dendritic growth, and synapse formation (Huang and Reichardt, 2001;Lewin and Barde, 1996). In addition to its prominent role in neuronal survival and differentiation during development, BDNF has emerged as a key regulator of synaptic plasticity and behavior (McAllister et al, 1999;Poo, 2001;Lu, 2003).…”

Section: Bdnfmentioning

confidence: 99%

Interaction between BDNF and Serotonin: Role in Mood Disorders

Martinowich

2007

Neuropsychopharmacol

657

458

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Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

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“…TrkA is the receptor for NGF, TrkB is the receptor for brain-derived neurotrophic factor and NT4/5, whereas TrkC is the receptor for NT3 (Kaplan and Miller, 2000). The classic neurotrophic theory proposes that neuronal survival depends on the presence of trophic factors such as neurotrophins (LeviMontalcini and Angeletti, 1963;Huang and Reichardt, 2001), and that cell death, which occurs when these factors become limited, is strictly due to loss of survival signals. On neurotrophin binding, Trk receptors activate PI3K/Akt and Ras/MAP kinase pathways that are thought to inhibit the naturally occurring death program in neurons (Kaplan and Miller, 2000).…”

Section: Dependence Receptors: a Short Historymentioning

confidence: 99%

Dependence receptors: a new paradigm in cell signaling and cancer therapy

2010

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Dependence receptors (DRs) now form a family of more than a dozen membrane receptors that are not linked by their structure, but by common functional traits. The most notable is their ability to trigger two opposite signaling pathways: in the presence of ligand, these receptors activate classic signaling pathways implicated in cell survival, migration and differentiation. In the absence of ligand, they do not stay inactive, rather they elicit an apoptotic signal. Thus, cells expressing this kind of receptor are dependent on the presence of ligand in the extracellular environment to survive. This review will recapitulate the increasing data regarding the molecular mechanisms associated with DRs, their potential implication during development, as well as their deregulation during tumorigenesis and, finally, their emergence as new possible therapeutic targets for cancer treatment.

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Neurotrophins: Roles in Neuronal Development and Function

Cited by 3,736 publications

References 332 publications

Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells

Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells

Interaction between BDNF and Serotonin: Role in Mood Disorders

Dependence receptors: a new paradigm in cell signaling and cancer therapy

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