Neurotrophins And Neurotrophin Receptors In Pulmonary Sarcoidosis - Granulomas As A Source Of Expression

Dagnell, Charlotta; Grünewald, Johan; Kramar, Marija; Haugom-Olsen, Helga; Elmberger, Göran; Eklúnd, Anders; Höglund, Caroline Olgart

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5704

Cited by 5 publications

(6 citation statements)

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“…There is evidence of increased expression of neurotrophins, such as nerve growth factor and their receptors, on airway lymphocytes of patients with sarcoidosis [32]. Furthermore, DAGNELL et al [33,34] have reported the presence of nerve growth factors and their receptors, such as TrkA, TrkB and TrkC, in sarcoid granulomas and alveolar macrophages. The neuronal mechanisms of cough should be explored further in patients with sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Predictors of objective cough frequency in pulmonary sarcoidosis

et al. 2016

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Cough is a common symptom of pulmonary sarcoidosis. This study aimed to quantify cough frequency, and investigate its relationship with cough reflex sensitivity, pulmonary function and health status.32 patients with pulmonary sarcoidosis were compared with 40 healthy controls. Cough reflex sensitivity to capsaicin, objective 24-h cough counts, cough-specific health status, cough severity and cough triggers were measured. The predictors of cough frequency in sarcoidosis were determined in a multivariate analysis.Objective cough frequency was significantly raised in patients with sarcoidosis compared with healthy controls (p<0.001) and patients with cough had an impaired health status. Patients with pulmonary sarcoidosis had a heightened cough reflex sensitivity compared with healthy controls (p<0.001). Only cough reflex sensitivity was significantly associated with objective cough frequency in multivariate analysis, explaining 42% of the variance (p<0.001). There was no association between cough frequency, lung function, number of organs involved, chest radiograph stage or serum angiotensin-converting enzyme levels.Cough is a common and significant symptom in patients with sarcoidosis. Ambulatory objective cough monitoring provides novel insights into the determinants of cough in sarcoidosis, suggesting that cough reflex sensitivity may be more important than lung function and other measures of disease severity, and this should be investigated further.

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Section: Discussionmentioning

confidence: 99%

Predictors of objective cough frequency in pulmonary sarcoidosis

et al. 2016

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“…Recently lymphocytes, and in particular activated T-cells, have been revealed to express BDNF and BDNF receptors in the experimental animal model of pulmonary sarcoidosis and chemical lung injury. 39,40 So, it is possible that neurotrophin up-regulation is secondary to rapid lymphocyte activation by H1N1 virus infection and that this over-expression represents an important process in the mechanisms of the inflammatory host response after viral lung infections. 23 In fact, previous studies have reported that different viral lung infections are associated with early neurotrophin biosynthesis, mainly BDNF and neurotrophin-3 (NT-3), suggesting that the changes in neurotrophin release may contribute to the development of lung inflammation and airway remodeling.…”

Section: Discussionmentioning

confidence: 99%

Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case–control study

Chiaretti

Pulitanò

Conti

et al. 2013

International Journal of Infectious Diseases

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“…Neurotrophin plasma levels increase in several inflammatory diseases, whereas up-regulation of TrkA/TrkB receptors has been shown following different inflammatory stimuli, such as allergen provocation and asthma. Recently lymphocytes, and in particular activated T-cells, were revealed to express BDNF and BDNF receptors in the experimental animal model of pulmonary sarcoidosis and chemical lung injury [29,30]. So, it is possible that neurotrophin up-regulation is secondary to lymphocytes rapid activation by H1N1 virus infection and that this over-expression represents an important process in the mechanisms of inflammatory host response after viral lung infections [18].…”

Section: Discussionmentioning

confidence: 99%

Circulating Plasma Levels of Neurotrophins are Increased in Children with H1N1 Virus Infection

Barone¹,

Buonsenso²

2013

J Cell Sci Ther

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Aim: To evaluate the correlation between neurotrophin expression and clinical findings, disease severity, and outcome of children with H1N1 viral infection. Methods: Prospective observational clinical study performed on 15 children with H1N1 infection and 15 controls with lower respiratory tract infections. Neurotrophic factor Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), and Glial Derived Neurotrophic Factor (GDNF) plasma levels were measured using immunoenzymatic assays. Results: Significantly higher levels of BDNF and NGF were detected in patients with H1N1 infection respect to controls, while GDNF did not show significant variations in both groups. In H1N1 patients with more severe clinical manifestations BDNF and NGF levels were significantly higher respect to H1N1 patients with mild clinical manifestations. Noteworthy, NGF up-regulation was associated with duration of cough. No correlation was found between neurotrophic factor expression and final outcome. Conclusions: H1N1 infection induces an early and significantly BDNF and NGF up-regulation. The overexpression of these molecular markers, namely NGF, is likely to play a neuro-immunomodulatory role in H1N1 infection and may contribute to airway inflammation and bronchial hyperreactivity in infected children.

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Neurotrophins And Neurotrophin Receptors In Pulmonary Sarcoidosis - Granulomas As A Source Of Expression

Cited by 5 publications

References 0 publications

Predictors of objective cough frequency in pulmonary sarcoidosis

Predictors of objective cough frequency in pulmonary sarcoidosis

Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case–control study

Circulating Plasma Levels of Neurotrophins are Increased in Children with H1N1 Virus Infection

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