Neurotrophin regulation of neural circuit development and function

Park, Hyungju; Poo, Mu‐ming

doi:10.1038/nrn3379

Cited by 1,648 publications

(1,391 citation statements)

References 216 publications

Supporting

Mentioning

1,293

Contrasting

Unclassified

Order By: Relevance

“…However, at this point the timing and relative role of the pre-and post-synaptic region in the release of BDNF still remains to be elucidated. This has been reviewed elsewhere Park and Poo, 2013) and will not be further discussed here.…”

Section: Bdnf and Ltp In The Hippocampusmentioning

confidence: 99%

“…The neurotrophin brain-derived neurotrophic factor (BDNF) has been shown to play a key role as mediator of activity-induced LTP in the hippocampus as well as in other brain regions (Bramham and Messaoudi, 2005;Cowansage et al, 2010;Lu et al, 2008;Minichiello, 2009;Park and Poo, 2013;Santos et al, 2010). The early effects of BDNF result from the modification of components already available at the synapse (e.g.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

BDNF-induced local protein synthesis and synaptic plasticity

2014

View full text Add to dashboard Cite

a b s t r a c tBrain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and longterm potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF in LTP are mediated by TrkB (tropomyosin-related kinase B) receptors, which are known to be coupled to the activation of the Ras/ERK, phosphatidylinositol 3-kinase/Akt and phospholipase C-g (PLC-g) pathways. The role of BDNF in LTP is best studied in the hippocampus, where the neurotrophin acts at pre-and post-synaptic levels. Recent studies have shown that BDNF regulates the transport of mRNAs along dendrites and their translation at the synapse, by modulating the initiation and elongation phases of protein synthesis, and by acting on specific miRNAs. Furthermore, the effect of BDNF on transcription regulation may further contribute to long-term changes in the synaptic proteome. In this review we discuss the recent progress in understanding the mechanisms contributing to the short-and long-term regulation of the synaptic proteome by BDNF, and the role in synaptic plasticity, which is likely to influence learning and memory formation.This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'.

show abstract

Section: Bdnf and Ltp In The Hippocampusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

BDNF-induced local protein synthesis and synaptic plasticity

2014

View full text Add to dashboard Cite

show abstract

“…One of the most prominent targets of MeCP2 transcriptional regulation is the gene encoding brain-derived neurotrophic factor (BDNF) [76,77], a neurotrophin well known for its critical role in neuronal growth, synapse formation, and activity-dependent plasticity through activation of its selective tropomyosin receptor kinase B (TrkB) receptors [78]. MeCP2 controls BDNF expression through complex interactions [79,80].…”

Section: Neurotrophins and Growth Factors: Brain-derived Neurotrophicmentioning

confidence: 99%

Rett Syndrome: Reaching for Clinical Trials

2015

View full text Add to dashboard Cite

Rett syndrome (RTT) is a syndromic autism spectrum disorder caused by loss-of-function mutations in MECP2. The methyl CpG binding protein 2 binds methylcytosine and 5-hydroxymethycytosine at CpG sites in promoter regions of target genes, controlling their transcription by recruiting co-repressors and co-activators. Several preclinical studies in mouse models have identified rational molecular targets for drug therapies aimed at correcting the underlying neural dysfunction. These targeted therapies are increasingly translating into human clinical trials. In this review, we present an overview of RTT and describe the current state of preclinical studies in methyl CpG binding protein 2-based mouse models, as well as current clinical trials in individuals with RTT.

show abstract

“…They examined whether different transcripts are related to specific BDNF-dependent phenotypes with these four mouse lines (Bdnf-e1, -e2, -e4, and -e6 mice) in which BDNF production is selectively impaired from each of the four major promoters (I, II, IV, or VI). Of note, promoter I and IV are the two promoters that have previously been shown to be induced by neuronal activity (Park and Poo, 2013). Intriguingly, Bdnf-e1 and -e2 mice displayed significantly different molecular, cellular, and behavioral phenotypes from Bdnf-e4 and -e6 mice.…”

mentioning

confidence: 93%

“…Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family shown initially to influence the differentiation and survival of neurons (Barde et al, 1982) and subsequently established to mediate in the central nervous system (CNS) higher order activities, such as synaptic plasticity, and learning and memory (Park and Poo, 2013). BDNF is widely expressed throughout the CNS, and in response to neuronal depolarization, BDNF is secreted into the synapse leading to the activation of tropomyosin receptor kinase B and its downstream signaling cascades that contribute to gene transcriptional events critical for synaptic plasticity and cognitive function.…”

mentioning

confidence: 99%