Neurotrophin production in brain pericytes during hypoxia: A role of pericytes for neuroprotection

Ishitsuka, Koji; Ago, Tetsuro; Arimura, Koichi; Nakamura, Kuniyuki; Tokami, Himiko; Makihara, Noriko; Kuroda, Junya; Kamouchi, Masahiro; Kitazono, Takanari

doi:10.1016/j.mvr.2012.02.009

Cited by 72 publications

(60 citation statements)

References 32 publications

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“…3,45,46 We have shown the neuroprotective roles of pericytes in brain ischemia. 47, 48 The present study demonstrated that PDGFR-β-positive cells accumulated in the peri-infarct area and encircled capillary lumens during the early phase of ischemia. Furthermore, we have found that several PDGFR-β-positive cells were colocalized with phosphorylated CREB and IL-6 at the early phase of ischemic insult and that the expression of IL-6 in the penumbra area tended to be reduced in the PDGFR-β+/− mice.…”

Section: Discussionsupporting

confidence: 51%

“…CREB in pericytes may contribute to angiogenesis, neurogenesis, and neuroprotection by initiating these processes after brain ischemia. 3,4,47,48 In the ischemic penumbra, the decrease in the glucose supply is mild in comparison with the oxygen supply. Because intracellular protons cause mitochondrial disorder, oxidative glucose metabolism is impaired.…”

Section: Discussionmentioning

confidence: 99%

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Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca ²⁺ Oscillation in Central Nervous System Pericytes

Nakamura

Kamouchi

Arimura

et al. 2012

ATVB

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca ²⁺ Oscillation in Central Nervous System Pericytes

Nakamura

Kamouchi

Arimura

et al. 2012

ATVB

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“…neurons or indirectly via their immunomodulatory properties or the secretion of neurotrophins [74] . Consistent with this idea is the observation that pericytes migrate away from the vascular wall and could generate neurons in response to injury [75,76] .…”

Section: Neurovascular Unitmentioning

confidence: 99%

Brain mesenchymal stem cells: The other stem cells of the brain?

Appaix

Nissou

Sanden

et al. 2014

WJSC

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Multipotent mesenchymal stromal cells (MSC), have the potential to differentiate into cells of the mesenchymal lineage and have non-progenitor functions including immunomodulation. The demonstration that MSCs are perivascular cells found in almost all adult tissues raises fascinating perspectives on their role in tissue maintenance and repair. However, some controversies about the physiological role of the perivascular MSCs residing outside the bone marrow and on their therapeutic potential in regenerative medicine exist. In brain, perivascular MSCs like pericytes and adventitial cells, could constitute another stem cell population distinct to the neural stem cell pool. The demonstration of the neuronal potential of MSCs requires stringent criteria including morphological changes, the demonstration of neural biomarkers expression, electrophysiological recordings, and the absence of cell fusion. The recent finding that brain cancer stem cells can transdifferentiate into pericytes is another facet of the plasticity of these cells. It suggests that the perversion of the stem cell potential of pericytes might play an even unsuspected role in cancer formation and tumor progression.

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“…NTRK1 and NTRK3 encode for tyrosine kinase receptors TrkA and TrkC, respectively. Nerve growth factor (NGF) preferentially binds to TrkA whereas neurotrophin-3 (NT3) binds at high affinity to TrkC to promote neuron survival and synaptic plasticity [Lamballe et al, 1991;Reichardt, 2006], including in hypoxic conditions [Lee et al, 2003;Lin et al, 2006;Ishitsuka et al, 2012]. TrkA is expressed in various neuronal populations including cholinergic neurons in the basal forebrain and striatum [Holtzman et al, 1995].…”

Section: Discussionmentioning

confidence: 99%

Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity

Smith

Anastopoulos

Garrett

et al. 2014

American J of Med Genetics Pt B

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Low birth weight is associated with increased risk for AttentionDeficit/Hyperactivity Disorder (ADHD); however, the etiological underpinnings of this relationship remain unclear. This study investigated if genetic variants in angiogenic, dopaminergic, neurotrophic, kynurenine, and cytokine-related biological pathways moderate the relationship between birth weight and ADHD symptom severity. A total of 398 youth from two multi-site, family-based studies of ADHD were included in the analysis. The sample consisted of 360 ADHD probands, 21 affected siblings, and 17 unaffected siblings. A set of 164 SNPs from 31 candidate genes, representing five biological pathways, were included in our analyses. Birth weight and gestational age data were collected from a state birth registry, medical records, and parent report.Generalized Estimating Equations tested for main effects and interactions between individual SNPs and birth weight centile in predicting ADHD symptom severity. SNPs within neurotrophic (NTRK3) and cytokine genes (CNTFR) were associated with

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Neurotrophin production in brain pericytes during hypoxia: A role of pericytes for neuroprotection

Cited by 72 publications

References 32 publications

Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca ²⁺ Oscillation in Central Nervous System Pericytes

Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca ²⁺ Oscillation in Central Nervous System Pericytes

Brain mesenchymal stem cells: The other stem cells of the brain?

Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity

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Neurotrophin production in brain pericytes during hypoxia: A role of pericytes for neuroprotection

Cited by 72 publications

References 32 publications

Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca 2+ Oscillation in Central Nervous System Pericytes

Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca 2+ Oscillation in Central Nervous System Pericytes

Brain mesenchymal stem cells: The other stem cells of the brain?

Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity

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Product

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Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca ²⁺ Oscillation in Central Nervous System Pericytes

Extracellular Acidification Activates cAMP Responsive Element Binding Protein via Na+/H+ Exchanger Isoform 1–Mediated Ca ²⁺ Oscillation in Central Nervous System Pericytes