“…BDNF is a therapeutic target in neonatal brain injury because of its putative role in brain plasticity, enhancing neuronal survival, migration and differentiation, supporting neurogenesis and improving outcomes in adult ischemic and neonatal HI models (Marini et al, 2007, Yasuhara et al, 2010, Douglas-Escobar et al, 2012, Han et al, 2012, Rosenkranz et al, 2012). However, early BDNF exposure after oxidative stress and oxygen-glucose deprivation injury may also exacerbate neuronal death (Gwag et al, 1995, Koh et al, 1995, Kim et al, 2003).…”