Neurotrophin biology at NGF 2016: From fundamental science to clinical applications

Plotkin, Joshua L.; Wu, Chengbiao

doi:10.1016/j.ijdevneu.2016.11.005

Cited by 2 publications

(1 citation statement)

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“…Considering it is not associated with any established organization or learned society, its overall stability and staying power is even more remarkable. The latest meeting (Figure 7), envisioned as a 30-year anniversary of the first meeting, continued the tradition and allowed some reflection on where the field has gone over the period between the two meetings [48]. The field has advanced enormously and continues to do so.…”

Section: The International Ngf Meeting Seriesmentioning

confidence: 99%

Nerve Growth Factor and Related Substances: A Brief History and an Introduction to the International NGF Meeting Series

Bradshaw

Mobley

Rush

2017

IJMS

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Nerve growth factor (NGF) is a protein whose importance to research and its elucidation of fundamental mechanisms in cell and neurobiology far outstrips its basic physiological roles. It was the first of a broad class of cell regulators, largely acting through autocrine and paracrine interactions which will be described herein. It was of similar significance in establishing the identity and unique roles of neurotrophic factors in the development and maintenance of the peripheral and central nervous systems. Finally, it contributed to many advances in the elaboration of cell surface receptor mechanisms and intracellular cell signaling. As such, it can be considered to be a “molecular Rosetta Stone”. In this brief review, the highlights of these various studies are summarized, particularly as illustrated by their coverage in the 13 NGF international meetings that have been held since 1986.

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Section: The International Ngf Meeting Seriesmentioning

confidence: 99%