1996
DOI: 10.1111/j.1460-9568.1996.tb01212.x
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Neurotrophin‐4/5 Maintains the Cholinergic Phenotype of Axotomized Septal Neurons

Abstract: We examined the effect of intraseptal or intracerebroventricular (i.c. v.) infusions of NT-4/5 or intraseptal infusions of NGF on the level of immunohistochemical staining of choline acetyltransferase (ChAT)and the low-affinity nerve growth factor receptor (LNGFR)in the rat medial septum following unilateral transection of the fimbria. The extent of cell loss in the septum ipsilateral to the lesion, determined by cell counts of ChAT-immunopositive neurons and expressed as a ratio comparing the lesioned to the … Show more

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Cited by 29 publications
(15 citation statements)
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References 50 publications
(55 reference statements)
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“…NT4 is supplied to thalamic neurons by layer IV and VI target neurons or with anterograde delivery by layer VI corticothalamic projections. Besides, the TrkB ligands may also serve other afferent systems, because, for instance, basal forebrain and noradrenergic projections express TrkB receptors (Alderson et al ., 1996).…”
Section: Discussionmentioning
confidence: 99%
“…NT4 is supplied to thalamic neurons by layer IV and VI target neurons or with anterograde delivery by layer VI corticothalamic projections. Besides, the TrkB ligands may also serve other afferent systems, because, for instance, basal forebrain and noradrenergic projections express TrkB receptors (Alderson et al ., 1996).…”
Section: Discussionmentioning
confidence: 99%
“…The effects of other exogenously applied neurotrophic factors on the number of ChAT-immunoreactive neurons following fimbriafornix transection have been described in the literature (e.g. Anderson et al, 1988;Otto et al, 1989;Hagg et al, 1992;Knusel et al, 1992;Alderson et al, 1996).…”
Section: Ngf Immunoreactivity and Ngf Receptor Expression In Medial Smentioning
confidence: 99%
“…Choline acetyltransferase (ChAT) is the enzyme responsible for the synthesis of acetylcholine. ChAT activity and acetylcholine release in vitro and in vivo are known to be promoted by several trophic factors, including nerve growth factor (NGF), brain‐derived neurotrophic factor (BDNF), and fibroblast growth factor (FGF; Grothe et al, 1989; Alderson et al, 1990, 1996; Rylett and Williams, 1994; Yokoyama et al, 1994; Nonner et al, 2000; Burgess and Aubert, 2006).…”
mentioning
confidence: 99%