Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain

Siegel, George J.; Chauhan, Neelima B.

doi:10.1016/s0165-0173(00)00030-8

Cited by 461 publications

(305 citation statements)

References 216 publications

Supporting

Mentioning

287

Contrasting

Unclassified

Order By: Relevance

“…Neurotrophins are proteins necessary for neuronal survival in aging and neuropathological conditions (Siegel and Chauhan 2000). When neurotrophin synthesis is decreased, spatial navigation is compromised (Siegel and Chauhan 2000).…”

Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

“…When neurotrophin synthesis is decreased, spatial navigation is compromised (Siegel and Chauhan 2000). The hippocampus is involved in spatial navigation, processing, and learning, and is especially sensitive to age or pathology related degeneration.…”

Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

“…NT-3, a protein found in the hippocampus and neocortex, protects nerve transmission and synapticity Kang and Schuman 2000;Siegel and Chauhan 2000). The protein also increases signal transmission in hippocampal cells which are known to have high levels of VDR mRNA Eyles, Smith et al 2005).…”

Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

308

222

View full text Add to dashboard Cite

show abstract

Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

308

222

View full text Add to dashboard Cite

show abstract

“…BDNF protects hippocampal neurons from glutamate toxicity (2) and reduces ischemic injury (3). BDNF is of particular therapeutic interest because of its neurotrophic actions on neuronal populations involved in several disorders, including amyotrophic lateral sclerosis (4), Parkinson disease, and Alzheimer's disease (5). However, clinical trials using recombinant BDNF have been disappointingly negative (6), presumably because of poor delivery, short half-life, and other limitations.…”

mentioning

confidence: 99%

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

Jang

Liu²,

Yepes³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

597

595

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report the identification of 7,8-dihydroxyflavone as a bioactive high-affinity TrkB agonist that provokes receptor dimerization and autophosphorylation and activation of downstream signaling. 7,8-Dihydroxyflavone protected wild-type, but not TrkB-deficient, neurons from apoptosis. Administration of 7,8-dihydroxyflavone to mice activated TrkB in the brain, inhibited kainic acid-induced toxicity, decreased infarct volumes in stroke in a TrkB-dependent manner, and was neuroprotective in an animal model of Parkinson disease. Thus, 7,8-dihydroxyflavone imitates BDNF and acts as a robust TrkB agonist, providing a powerful therapeutic tool for the treatment of various neurological diseases.

show abstract

“…This model can be exploited to perform accurate quantitation of cell death and survival. A well-studied candidate for promotion of cell survival and regeneration is neurotrophic factors, where glial-cell derived neurotrophic factors (GDNF) and brain-derived neurotrophic factors (BDNF) are shown to have the most pronounced effects (359)(360)(361)(362). It is unclear however, which of these factors that are most potent.…”

Section: Aimsmentioning

confidence: 99%