Neurotrimin: a novel neural cell adhesion molecule correlating with uterine fibroid phenotype

Takala, Hajra; Al-Hendy, Ayman; Yang, Qiwei

doi:10.1016/j.fertnstert.2019.09.026

Cited by 2 publications

(5 citation statements)

References 5 publications

(24 reference statements)

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“…Soluble PVR (sPVR) isoforms can be found in a variety of bodily fluids, including the urine, blood serum, and cerebrospinal fluid 35 . Previous studies indicated that sPVR was found in higher serum concentrations compared to healthy donors across a broad spectrum of cancer patients, including the lung, gastrointestinal, breast, ovarian, and colorectal cancers 36 . Thus, sPVR is a potential biomarker for monitoring the progress of some cancers.…”

Section: Resultsmentioning

confidence: 99%

“…35 Previous studies indicated that sPVR was found in higher serum concentrations compared to healthy donors across a broad spectrum of cancer patients, including the lung, gastrointestinal, breast, ovarian, and colorectal cancers. 36 Thus, sPVR is a potential biomarker for monitoring the progress of some cancers. In this study, we provide the first evidence of significantly increased PVR levels in the urine of TB patients (36 out of 52) compared to non-TB controls (five out of 52).…”

Section: Multiple Reaction Monitoring Verificationmentioning

confidence: 99%

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Urinary proteomic analysis to identify a potential protein biomarker panel for the diagnosis of tuberculosis

Liu

Deng

Yang³

et al. 2021

IUBMB Life

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Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the primary causes of death worldwide. Rapid and accurate diagnosis of TB is one of the most direct means to reduce the incidence of TB. In this study, urinary proteomic profiling of TB patients and non-TB individual controls (HCs) was performed, and differentially expressed urinary proteins between TB and HCs were compared and exclusively expressed proteins in TB patients were selected to establish a clinically useful disease marker panel. In total, these top 11 targeted proteins with 265 peptides were scheduled for multiple reaction monitoring validation analysis by using urine samples from 52 TB patients and 52 HCs. The result demonstrated that a three-protein combination out of the five-protein panel (namely P22352, Q9P121, P15151, Q13291, and Q8NDA2) exhibited sensitivity rate of 82.7% in the diagnosis of TB. Furthermore, the three-protein combination could differentiate TB from the latent tuberculosis (LTB) effectively, which exhibited specificity rate of 92.3% for the diagnosis of TB from the LTB category. Although more numbers of clinical samples are required for further verification, the results provided preliminary evidence that

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Section: Resultsmentioning

confidence: 99%

Section: Multiple Reaction Monitoring Verificationmentioning

confidence: 99%

Urinary proteomic analysis to identify a potential protein biomarker panel for the diagnosis of tuberculosis

Liu

Deng

Yang³

et al. 2021

IUBMB Life

View full text Add to dashboard Cite

show abstract

“…The G-protein-coupled estrogen receptor 1 (GPER-1) mRNA, which might play a role in endometrial biology, was found in all endometrial and decidual tissue samples. 5,45,46…”

Section: Neuromodulation Of the Uterusmentioning

confidence: 99%

“…For example, sensory function in the nongravid uterus can be estimated through the investigation of NTM, a fixed neuronal cell adhesion molecule that regulates the development of neuronal projections in the uterus, and is in turn regulated by estrogen. 5 The NTM expression is increased in painful uterine diseases such as leiomyoma, suggesting its role in transmitting sensory information in normal uterine neurophysiology. 38…”

Section: Localization Of Nerve Fibersmentioning

confidence: 99%