Neurotransmitters, receptors, and neuropeptides in the accessory optic system: An immunohistochemical survey in the pigeon (<i>Columba livia</i>)

Britto, Luiz Roberto Giorgetti de; Hamassaki‐Britto, Dânia Emi; Keyser, Kent T.; Karten, Harvey J.

doi:10.1017/s0952523800005964

Cited by 36 publications

(8 citation statements)

References 68 publications

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“…AngII in the retina may primarily act as a neurotransmitter or neuromodulator [16,19]. Besides AngII, substance P has been identified as a target neuropeptide for the catabolic activities of ACE in the retina [41] emphasizing the neuromodulatory role of the RAS in this area. In particular, the ganglion cells were strongly immunoreactive for ACE and AngII in our study.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of Angiotensin-Converting Enzyme, Angiotensin II and AT1 Receptor in Human Ocular Tissues

et al. 2004

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We investigated the immunohistochemical distribution of 3 components of the renin-angiotensin system (RAS), angiotensin-converting enzyme (ACE), angiotensin II (AngII) and AT1 receptor (AT1), in the human eye. ACE and AngII were localized to nonpigmented epithelial cells of the ciliary body, to endothelial and epithelial cells of the cornea, to epithelial cells of the conjunctiva and to trabecular meshwork cells in the anterior part of the eye. In the posterior part of the eye, ACE and AngII were localized to ganglion cells, some cells in the inner nuclear layer, photoreceptor cells and to endothelial cells of the retinal and choroidal vessels. The overall intensity of AT1 immunoreactivity was weak in all ocular tissues, but the main localization was in ganglion cells. As a preliminary investigation, we were able to include 2 Alzheimer’s disease (AD) cases. In AD, no differences from controls were found in the cellular distribution and staining intensity of all 3 antigens. The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localization of Angiotensin-Converting Enzyme, Angiotensin II and AT1 Receptor in Human Ocular Tissues

et al. 2004

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“…Its ganglion cells project to three target nuclei in the anterior portion of the midbrain: the dorsal, medial, and lateral terminal nuclei (70)(71)(72). The morphology of retinal ganglion cells projecting to the terminal nuclei was first studied in the pigeon by Karten and collaborators in the 1970s (72)(73)(74). They showed that these were the displaced ganglion cells of Dogiel whose distribution on the retinal surface was remarkably orderly.…”

Section: Accessory Optic Systemmentioning

confidence: 99%

Parallel information processing channels created in the retina

Schiller

2010

Proc. Natl. Acad. Sci. U.S.A.

101

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In the retina, several parallel channels originate that extract different attributes from the visual scene. This review describes how these channels arise and what their functions are. Following the introduction four sections deal with these channels. The first discusses the "ON" and "OFF" channels that have arisen for the purpose of rapidly processing images in the visual scene that become visible by virtue of either light increment or light decrement; the ON channel processes images that become visible by virtue of light increment and the OFF channel processes images that become visible by virtue of light decrement. The second section examines the midget and parasol channels. The midget channel processes fine detail, wavelength information, and stereoscopic depth cues; the parasol channel plays a central role in processing motion and flicker as well as motion parallax cues for depth perception. Both these channels have ON and OFF subdivisions. The third section describes the accessory optic system that receives input from the retinal ganglion cells of Dogiel; these cells play a central role, in concert with the vestibular system, in stabilizing images on the retina to prevent the blurring of images that would otherwise occur when an organism is in motion. The last section provides a brief overview of several additional channels that originate in the retina. midget channels | ON/OFF channels | parasol channels

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“…Nevertheless, target peptides tor the catabolic effects of ACE, e.g. substance P (Britto et al, 1989), as well as its anabolic product AngII (Datum and Zrenner, 1991) are present in avian ganglion cells.…”

Section: Figmentioning

confidence: 99%

Expression of Angiotensin-converting Enzyme (ACE) in the Developing Chicken Retina

Wheeler‐Schilling

Sautter

Guenther

et al. 2001

Experimental Eye Research

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Neurotransmitters, receptors, and neuropeptides in the accessory optic system: An immunohistochemical survey in the pigeon (Columba livia)

Cited by 36 publications

References 68 publications

Immunohistochemical Localization of Angiotensin-Converting Enzyme, Angiotensin II and AT1 Receptor in Human Ocular Tissues

Immunohistochemical Localization of Angiotensin-Converting Enzyme, Angiotensin II and AT1 Receptor in Human Ocular Tissues

Parallel information processing channels created in the retina

Expression of Angiotensin-converting Enzyme (ACE) in the Developing Chicken Retina

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