Neurotransmitter receptors in the pulmonary circulation with particular emphasis on pulmonary endothelium

Kobayashi, Yuta; Amenta, Francesco

doi:10.1111/j.1474-8673.1994.tb00598.x

Cited by 15 publications

(2 citation statements)

References 118 publications

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“…Pulmonary endothelium plays a key role in the regulation of vascular tone by releasing endothelium-derived vasoactive factors. Release of these factors is modulated in part via neurotransmitter receptors expressed by endothelial cells [24]. Endothelium-derived factors were also demonstrated to interfere with adrenergic neurotransmission through feedback mechanisms [31].…”

Section: Discussionmentioning

confidence: 99%

“…Control mechanisms in pulmonary circulation may differ from those of systemic circulation. It is known that pulmonary vascular tone is influenced and regulated by multiple factors, including autonomic nervous system and several vasoactive compounds [24]. However, our knowledge of mechanisms involved in the control of pulmonary circulation is incomplete.…”

Section: Introductionmentioning

confidence: 99%

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Neurotrophins and Neurotrophin Receptors in Human Pulmonary Arteries

Rícci

Greco²,

Amenta³

et al. 2000

J Vasc Res

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The localization of neurotrophins (NTs) and NT receptors was analyzed in sections of human extra- and intrapulmonary arteries by Western blot analysis and immunohistochemistry. In extrapulmonary branches of human pulmonary artery, NT and NT receptor immunoreactivity was located in the tunica intima, within endothelium, in the tunica media, within smooth muscle and in the tunica adventitia. In different sized intrapulmonary arteries, NT and NT receptor immunoreactivity was observed primarily in the tunica adventitia. A faint NT and NT receptor immunoreactivity was observed in the tunica media of large-sized branches of intrapulmonary arteries, but not within medium- or small-sized intrapulmonary vessels or in tunica intima of different sized intrapulmonary arteries. These findings suggest that NTs may have a role in the control of vascular responses in the pulmonary system acting as local paracrine or autocrine mediators. The possible relevance of the NT system in human pulmonary vasculature identified in this study is discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%