Neurotransmission—Evolving Systems

Anctil, Michel

doi:10.1002/9781118316757.ch10

Cited by 1 publication

(1 citation statement)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current knowledge indicates that in Hydra species, the nerve net, one of the most primitive nervous systems to have evolved, shows a greater structural and functional complexity than previously acknowledged, modulating different behavioral responses through a variety of cellular effectors (reviewed in [ 46 ]). Neuronal signaling relies largely on neuropeptides, but increasing evidence of the occurrence of classical neurotransmitters is available [ 47 ]. Our group identified, characterized, and localized in Hydra tissues the receptors to inhibitory and excitatory amino acid neurotransmitters, GABA, glycine, and NMDA, that compare with mammalian ionotropic receptors by their biochemical and pharmacological properties [ 46 ].…”

Section: Gaba and Hydra : Available Evidencementioning

confidence: 99%

An Interesting Molecule: γ-Aminobutyric Acid. What Can We Learn from Hydra Polyps?

Pierobon

2021

Brain Sciences

View full text Add to dashboard Cite

Neuronal excitability is controlled primarily by γ-aminobutyric acid (GABA) in the central and peripheral nervous systems of vertebrate as well as invertebrate organisms. Besides its recognized neurotransmitter functions, GABA also plays a fundamental role in neurogenesis and synaptogenesis during embryonic development. In addition, GABAergic mechanisms are also involved in disorders of various peripheral tissues, ranging from diabetes to hypothyroidism to inflammatory responses. The discovery of the molecule and the history of its biosynthetic pathways in vertebrate and invertebrate phyla are summarized here. The occurrence and distribution of GABA, GABA-synthesizing enzymes, and receptors to GABA in the freshwater polyp Hydra vulgaris (Cnidaria: Hydrozoa), endowed with an early evolved nervous system, are discussed in relation to possible interactions with the microbiota, a stable component of Hydra polyps; their contribution to the evolution of nervous systems through microbe–neuronal interactions is proposed.

show abstract

Section: Gaba and Hydra : Available Evidencementioning

confidence: 99%

An Interesting Molecule: γ-Aminobutyric Acid. What Can We Learn from Hydra Polyps?

Pierobon

2021

Brain Sciences

View full text Add to dashboard Cite

show abstract

Neurotransmission—Evolving Systems

Cited by 1 publication

References 148 publications

An Interesting Molecule: γ-Aminobutyric Acid. What Can We Learn from Hydra Polyps?

An Interesting Molecule: γ-Aminobutyric Acid. What Can We Learn from Hydra Polyps?

Contact Info

Product

Resources

About