Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats

Xu, Yiquan; Kou, Jianqun; Wang, Shuzhi; Chen, Cao-Xin; Qin, Zheng‐Hong

doi:10.1016/j.intimp.2015.05.040

Cited by 12 publications

(14 citation statements)

References 47 publications

(60 reference statements)

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“…A recent study employing the use of radioactive derivative of α-bungarotoxin suggested the possible function of neuronal nAChR in the development of Parkinson’s disease [ 78 ]. Apart from serving as molecular probes in various medical disorders, three-finger neurotoxins are also gaining attention as potential analgesics, anti-inflammatory molecules, and immunosuppressant [ 79 ]. A neurotoxin characterized from Naja n. atra venom in rats suppressed skin allograft rejection by inhibiting the T-cell-mediated immune response [ 79 ].…”

Section: Snake Venom Peptides and Their Potential Pharmacological mentioning

confidence: 99%

“…Apart from serving as molecular probes in various medical disorders, three-finger neurotoxins are also gaining attention as potential analgesics, anti-inflammatory molecules, and immunosuppressant [ 79 ]. A neurotoxin characterized from Naja n. atra venom in rats suppressed skin allograft rejection by inhibiting the T-cell-mediated immune response [ 79 ]. A new group of three-finger toxins (namely, Ω-neurotoxins) were also recently isolated from the venom of the Ophiophagus hannah snake.…”

Section: Snake Venom Peptides and Their Potential Pharmacological mentioning

confidence: 99%

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Snake Venom Peptides: Tools of Biodiscovery

Munawar

Ali

Akrem

et al. 2018

Toxins

107

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Nature endowed snakes with a lethal secretion known as venom, which has been fine-tuned over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive in their natural habitat. Venom is known to be a very poisonous mixture, consisting of a variety of molecules, such as carbohydrates, nucleosides, amino acids, lipids, proteins and peptides. Proteins and peptides are the major constituents of the dry weight of snake venoms and are of main interest for scientific investigations as well as for various pharmacological applications. Snake venoms contain enzymatic and non-enzymatic proteins and peptides, which are grouped into different families based on their structure and function. Members of a single family display significant similarities in their primary, secondary and tertiary structures, but in many cases have distinct pharmacological functions and different bioactivities. The functional specificity of peptides belonging to the same family can be attributed to subtle variations in their amino acid sequences. Currently, complementary tools and techniques are utilized to isolate and characterize the peptides, and study their potential applications as molecular probes, and possible templates for drug discovery and design investigations.

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Section: Snake Venom Peptides and Their Potential Pharmacological mentioning

confidence: 99%

Section: Snake Venom Peptides and Their Potential Pharmacological mentioning

confidence: 99%

Snake Venom Peptides: Tools of Biodiscovery

Munawar

Ali

Akrem

et al. 2018

Toxins

107

View full text Add to dashboard Cite

show abstract

“…Another study performed by Xu et al [ 68 ] evaluated the effects of NNAV and its component neurotoxin on skin allograft rejection in rats. As we know, acute rejection occurs several days or weeks after skin transplantation, which is induced by cytotoxic T cells, monocytes, or macrophages [ 69 , 70 ].…”

Section: Effect Of Nnav and Its Components On Inflammation And Immmentioning

confidence: 99%

“…For this reason, a new safe and effective agent for skin transplant rejection is sorely needed. Interestingly, Xu [ 68 ] found that NNAV and cobrotoxin extended skin allograft retention time in rats. In histological sections of skin, spleen, and thymus, NNAV and cobrotoxin inhibited inflammatory cells infiltration and recuperated the germinal center in immune organs.…”

Section: Effect Of Nnav and Its Components On Inflammation And Immmentioning

confidence: 99%

Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom

Wang

Qin

2018

Toxins

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Naja naja atra venom (NNAV) is composed of various proteins, peptides, and enzymes with different biological and pharmacological functions. A number of previous studies have reported that NNAV exerts potent analgesic effects on various animal models of pain. The clinical studies using whole venom or active components have confirmed that NNAV is an effective and safe medicine for treatment of chronic pain. Furthermore, recent studies have demonstrated that NNAV has anti-inflammatory and immune regulatory actions in vitro and in vivo. In this review article, we summarize recent studies of NNAV and its components on inflammation and immunity. The main new findings in NNAV research show that it may enhance innate and humoral immune responses while suppressing T lymphocytes-mediated cellular immunity, thus suggesting that NNAV and its active components may have therapeutic values in the treatment of inflammatory and autoimmune diseases.

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“…Cobratoxin, a long-chain neurotoxin, from Thailand cobra venom has been demonstrated to have potent actions on inhibiting formalin-induced inflammatory pain [ 19 ] and adjuvant arthritis [ 20 ]. Cobrotoxin (CTX), a short-chain neurotoxin, was suggested to inhibit NF- κ B signaling activation [ 21 ] and regulated T lymphocytes [ 22 ]. ADR-induced chronic nephropathy is related to inflammation reactions and immune responses.…”

Section: Introductionmentioning

confidence: 99%

Cobrotoxin fromNaja naja atraVenom Ameliorates Adriamycin Nephropathy in Rats

Wang

Zhu

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Chronic kidney disease (CKD) becomes a global health problem with high morbidity and mortality. Adriamycin- (ADR-) induced rodent chronic nephropathy is a classic experimental model of human minimal lesion nephrotic syndrome. The present study investigated the effect of cobrotoxin (CTX) on ADR-induced nephropathy. Rats were given 6 mg/kg ADR once through the tail vein to replicate ADR nephropathy model. CTX was administered to rats daily by placing a fast dissolving CTX membrane strip under the tongue starting from 5 days prior to ADR administration until the end of experiment. The results showed that CTX ameliorated the symptoms of ADR nephropathy syndrome with reduced body weight loss, proteinuria, hypoalbuminemia, dyslipidemia, serum electrolyte imbalance, oxidative stress, renal function abnormities, and kidney pathological lesions. Anti-inflammatory cytokine IL-10 expression was elevated after CTX administration in ADR nephropathy model. CTX inhibited the phosphorylation of IκB-α and NF-κB p65 nuclear translocation. Meanwhile, CTX upregulated the protein level of podocyte-specific nephrin and downregulated the level of fibrosis-related TGF-β. These findings suggest that CTX may be a potential drug for chronic kidney diseases.

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Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats

Cited by 12 publications

References 47 publications

Snake Venom Peptides: Tools of Biodiscovery

Snake Venom Peptides: Tools of Biodiscovery

Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom

Cobrotoxin fromNaja naja atraVenom Ameliorates Adriamycin Nephropathy in Rats

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