Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

Antsiferova, A. A.; Kopaeva, Marina Yu.; Kochkin, Vyacheslav; Reshetnikov, A. A.; Кашкаров, П. К.

doi:10.3390/mi14050984

Cited by 9 publications

(1 citation statement)

References 44 publications

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“…An extremely low clearance from the brain (~5%) in comparison to liver (~75%) and blood (~80%) after 2-month daily oral exposure to 34 nm sized polyvinylpyrrolidone coated silver nanoparticles and 1 month of washing out was observed in laboratory mice in [12]. We studied age differences influencing accumulation levels of silver in organs of laboratory mice at the 60-day oral exposure to 8.7 nm sized polyvinylpyrrolidone coated silver nanoparticles [13]. Accumulation of silver was observed in all the studied organs of the exposed animals.…”

Section: Introductionmentioning

confidence: 99%

Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Antsiferova,

Kopaeva,

Loginova

et al. 2023

Preprint

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Pure silver as well as silver compounds have been used as antiseptics for centuries. Nowadays, the most frequently applied form of silver is a nanoparticle form. Several studies demonstrate the ability of silver nanoparticles and silver salts to accumulate in the brain of laboratory ani-mals as well as the ability of silver nanoparticles to influence behavioral and cognitive functions of laboratory mammals. For the first time, the influence of a silver salt, in particular, silver citrate on the change dynamics of behavioral and cognitive functions of laboratory mice at the daily oral exposure during 30, 60, 120 and 180 days is investigated in the present research. We observed the anxiety increase after 30 days of the exposure as well as the ability of mice to adapt to the prolonged oral exposure of silver citrate manifested in the anxiety decrease, increase of locomotor activity and the tendency of long-term contextual memory improvement. Increase of locomotor activity and memory improvement might be associated with the sensitivity increase and regarded as compensatory mechanism to anxiety increase. The observed phenomenon is classified as a hormetic effect. A comparison with the analogous study implemented polyvi-nylpyrrolidone coated silver nanoparticles is carried out. It was concluded that the nanoform is more neurotoxic.

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Section: Introductionmentioning

confidence: 99%

Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Antsiferova,

Kopaeva,

Loginova

et al. 2023

Preprint

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Long-term application of silver nanoparticles in dental restoration materials: potential toxic injury to the CNS

Wang,

Yin

et al. 2023

J Mater Sci: Mater Med

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Silver nanoparticles (AgNPs) have durable and remarkable antimicrobial effects on pathogenic microorganisms, such as bacteria and fungi, in dental plaques. As such, they are widely added to dental restoration materials, including composite resins, denture bases, adhesives, and implants, to solve the problems of denture stomatitis, peri-implant inflammation, and oral infection caused by the long-term use of these dental restoration materials. However, AgNPs can be absorbed into the blood circulatory system through the nasal/oral mucosa, lungs, gastrointestinal tract, skin, and other pathways and then distributed into the lungs, kidneys, liver, spleen, and testes, thereby causing toxic injury to these tissues and organs. It can even be transported across the blood-brain barrier (BBB) and continuously accumulate in brain tissues, causing injury and dysfunction of neurons and glial cells; consequently, neurotoxicity occurs. Other nanomaterials with antibacterial or remineralization properties are added to dental restoration materials with AgNPs. However, studies have yet to reveal the neurotoxicity caused by dental restoration materials containing AgNPs. In this review, we summarize the application of AgNPs in dental restoration materials, the mechanism of AgNPs in cytotoxicity and toxic injury to the BBB, and the related research on the accumulation of AgNPs to cause changes of neurotoxicity. We also discuss the mechanisms of neurotoxicity caused by AgNPs and the mode and rate of AgNPs released from dental restorative materials added with AgNPs to evaluate the probability of neurotoxic injury to the central nervous system (CNS), and then provide a theoretical basis for developing new composite dental restoration materials. Graphical Abstract

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Molecular mechanisms of silver nanoparticle-induced neurotoxic injury and new perspectives for its neurotoxicity studies: A critical review

Yang,

Niu,

Guo

et al. 2024

Environmental Pollution

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Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

Cited by 9 publications

References 44 publications

Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Long-term application of silver nanoparticles in dental restoration materials: potential toxic injury to the CNS

Molecular mechanisms of silver nanoparticle-induced neurotoxic injury and new perspectives for its neurotoxicity studies: A critical review

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