1997
DOI: 10.1007/978-3-7091-6837-0_43
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Neurotoxicity of Serum Components, Comparison Between CA1 and Striatum

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Cited by 8 publications
(6 citation statements)
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“…To our knowledge, plasma has not been examined previously for its direct neurotoxic effects or its ability to modulate excitotoxic damage. However, autologous serum and rat albumin have been injected into the rat brain and neurotoxicity was observed (Hassel et al, 1994;Kadota et al, 1997). The difference in results between these studies and ours could be caused by a difference in protocols.…”
Section: Discussionmentioning
confidence: 64%
See 1 more Smart Citation
“…To our knowledge, plasma has not been examined previously for its direct neurotoxic effects or its ability to modulate excitotoxic damage. However, autologous serum and rat albumin have been injected into the rat brain and neurotoxicity was observed (Hassel et al, 1994;Kadota et al, 1997). The difference in results between these studies and ours could be caused by a difference in protocols.…”
Section: Discussionmentioning
confidence: 64%
“…The difference in results between these studies and ours could be caused by a difference in protocols. Whereas we infused plasma at a rate of 0.5 l/hr for 4 d, the previous studies injected a 25 l volume of serum or albumin into the rat brain in a shorter time (Hassel et al, 1994;Kadota et al, 1997). It is possible that the large volume injection coupled with increased fluid extravasation attributable to protein osmotic effects could have contributed to edema-mediated neuronal death in those studies.…”
Section: Discussionmentioning
confidence: 98%
“…31 In addition to potential effects on the transmigratory ability of inflammatory cells, altered BBB permeability may allow potentially toxic serum proteins, including thrombin, to enter the CNS. [52][53][54][55] It is interesting that thrombin has been shown to affect dendritic arborization, 54 which is reduced in association with HIVD. 56 Although similarly speculative, it is also possible that MMPs may have more direct effects on brain-derived cells.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, endothelial dysfunction contributes to BBB breakdown, resulting in the exudation of serum components into nervous tissue (Farooque et al, 1992). This may trigger apoptotic neuronal death and enhance superoxide production in microglia following vasogenic edema (Kadota et al, 1997;Si et al, 1997;Murakami et al, 1998). At longer survival periods, extensive extravasation of serum albumin has been described (Farooque et al, 1992).…”
Section: Introductionmentioning
confidence: 97%
“…Zones of ischemic brain tissue are always present around traumatic lesions and may persist for weeks or months due to astrocytic swelling and microvascular compression (Bullock et al, 1992a). Perivascular hemorrhage often exists in contusion (Shreiber et al, 1999), and glutamate may be released from areas of hemorrhage and their surround, further injuring neurons (Bullock et al, 1992bBaker et al, 1993;Zauner and Bullock, 1995;Kadota et al, 1997;Matsushita et al, 2000).…”
Section: Introductionmentioning
confidence: 99%