Neurotoxicity of Prosopis juliflora: from Natural Poisoning to Mechanism of Action of Its Piperidine Alkaloids

Silva, Víctor Diógenes Amaral da; Silva, André Mário Mendes da; Silva, Juliana Helena Castro E; Costa, Sílvia Lima

doi:10.1007/s12640-017-9862-2

Cited by 22 publications

(15 citation statements)

References 62 publications

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“…Despite this, the ethanolic extract had superior antimicrobial activity, which corroborates with a study that indicated that ethanolic and aqueous extracts are better to concentrate active metabolites of P. juliflora (Khandelwal, Sharma & Agrawal, 2016). Care should be taken with this plant because contains neurotoxic piperidine alkaloids (Silva, Silva, Silva & Costa, 2018). Research, Society and Development, v. 10, n. 11, e509101119875, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i11.19875…”

Section: Resultsmentioning

confidence: 99%

Antibacterial activity of Brazilian Northeast plants against Corynebacterium pseudotuberculosis

Alcântara

Farias

Sá

et al. 2021

RSD

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The production of small ruminants is an important economic activity of the brazilian Northeast, but some diseases have a high prevalence in this region, such as caseous lymphadenitis (CL), caused by Corynebacterium pseudotuberculosis. The treatment of CL is often ineffective, which justifies the search of new active principles from plants, mainly of the region, to have an accessible treatment. For this reason, the present study was carried out to evaluate the in vitro antibacterial activity of Annona squamosa, Azadirachta indica, Allium sativum, Prosopis juliflora and Portulaca oleracea against C. pseudotuberculosis. Agar well diffusion assay (AWD) and broth microdilution - to determine minimum inhibitory concentration (MIC) and bactericidal concentration (MBC) - evaluated the antimicrobial activity. The highest antibacterial potential was obtained by ethanolic extracts of A. indica leaf (MIC 0,12 mg/mL for 2 strains), A. squamosa stalk (MIC 0,55 mg/mL for 3 strains) and shell (MIC 0,6 mg/mL for 3 strains). These extracts also presented the highest inhibition zone in AWD (30 mm, 38 mm and 32 mm, respectively). A. squamosa and A. indica have high antimicrobial potential against C. pseudotuberculosis.

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Section: Resultsmentioning

confidence: 99%

Antibacterial activity of Brazilian Northeast plants against Corynebacterium pseudotuberculosis

Alcântara

Farias

Sá

et al. 2021

RSD

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“…Also, other clinical signs during rumination are seen like dysphagia, incoordination of chewing movements, atrophy, dysphagia and profuse salivation of the masseter muscle in animals, ruminal atony, anemia, submandibular edema and progressive weight loss [72]. All the symptoms result in degradation of brain flora like neuromuscular alteration, histologic lesions like spongiosis, gliosis, the loss of Nissl granules, fine vacuolation of the perikaryon of neurons from trigeminal motor nuclei and finally which results in the degeneration and disappearance of neuronal cells in the trigeminal motor nucleus [72,73].…”

Section: Toxicity Studiesmentioning

confidence: 99%

Pharmacological and pharmacognostical aspect of Prosopis juliflora: A review

Yadav¹,

Rana²

2020

World J. Adv. Res. Rev.

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Prosopis juliflora also called as mesquite or Velayati babul, found all over the world specially in semiarid and arid areas. It is a competitive weed and has been declared as noxious in several countries. WHO found that herbal medicines are used traditionally for the treatment of diseases, nearly 80% of the population utilize plants due to their less side effects and easy availability as compared to allopathic systems of medicine. Prosopis juliflora belongs to family Leguminosae and also has an effective role as traditional medicine. Every part of this species contains a large number of phytoconstituents mainly flavonoids, alkaloids, tannins, phenolics, terpenes and saponins. The plant possesses some pharmacological activity like antibacterial, anti-pustule, antitumor, larvicidal, anthelminthic, antimicrobial, antirheumatic, anti-inflammatory, antifungal, antioxidant, antimalarial activities. Despite of its various uses, it is a serious invasive weed and is cytotoxic in nature. Due to ingestion of Prosopis juliflora pods, a neurological disorder "Cara-torta" is most common in the ruminant animals like goats which directly affect mitochondria of nerve cell. So, this article is an aggregate of all the details and information of Prosopis juliflora plant published in different books and journals.

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“…Furthermore, mitochondrial damage in neurons and gliosis was reported in trigeminal nuclei of intoxicated cattle. Studies have reproduced the main cellular changes visualized in cara torta disease using neural cell and contributed to understanding the mechanism of action piperidine alkaloids, the main neurotoxic compound in P. juliflora leaves and pods [96]. One study showed that total alkaloids extract and fractions administration (at 30 µg/mL) stimulated cytotoxicity characterized by a strong cell body contraction with very thin and long processes and condensed chromatin, besides to simulate accumulation of nitrite in culture medium, thus suggesting NO production stimulation.…”

Section: Poisoning and Toxicitymentioning

confidence: 99%

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

et al. 2019

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Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/postpartum pains, callouses, conjunctivitis, diabetes, diarrhea, expectorant, fever, flu, lactation, liver infection, malaria, otitis, pains, pediculosis, rheumatism, scabies, skin inflammations, spasm, stomach ache, bladder and pancreas stone removal. Flour, syrup, and beverages from Prosopis pods have also been potentially used for foods and food supplement formulation in many regions of the world. In addition, various in vitro and in vivo studies have revealed interesting antiplasmodial, antipyretic, anti-inflammatory, antimicrobial, anticancer, antidiabetic and wound healing effects. The phytochemical composition of Prosopis plants, namely their content of C-glycosyl flavones (such as schaftoside, isoschaftoside, vicenin II, vitexin and isovitexin) has been increasingly correlated with the observed biological effects. Thus, given the literature reports, Prosopis plants have positive impact on the human diet and general health. In this sense, the present review provides an in-depth overview of the literature data regarding Prosopis plants’ chemical composition, pharmacological and food applications, covering from pre-clinical data to upcoming clinical studies.

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Neurotoxicity of Prosopis juliflora: from Natural Poisoning to Mechanism of Action of Its Piperidine Alkaloids

Cited by 22 publications

References 62 publications

Antibacterial activity of Brazilian Northeast plants against Corynebacterium pseudotuberculosis

Antibacterial activity of Brazilian Northeast plants against Corynebacterium pseudotuberculosis

Pharmacological and pharmacognostical aspect of Prosopis juliflora: A review

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

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