Neurotoxicity of Metrizamide

Ekholm, Sven; Fischer, Harry W.

doi:10.1001/archneur.1985.04060010030010

Cited by 9 publications

(2 citation statements)

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“…This penetration appears to take place by a simple diffusion (13) and in brain tissue no difference could be found between metrizamide and the ionic CM tested (20). However, another study found some difference in the spinal cord distribution of metrizamide compared with iohexol and an extracellular marker (6). Other studies have shown indications of some retention of metrizamide within the neural tissue when compared with iohexol (7,8).…”

Section: Discussionmentioning

confidence: 96%

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Local Glucose Utilization Changes Caused by Subarachnoid Contrast Media in the Rabbit

et al. 1990

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The glucose metabolism effects of six hour exposures to subarachnoid injections of metrizamide, iohexol, iodixanol and control solutions were studied in vivo in 18 rabbits. The brain tissue uptake of intravenously injected 14C labelled deoxyglucose was measured using auto radiographic techniques. Metrizamide and iodixanol caused significant (p < 0.05) decreases in deoxyglucose uptake in the outer cortical areas where the contrast medium concentrations were highest. Iohexol and the control CSF solution did not cause significant effects. The results appear to indicate that iohexol has less effect on brain tissue glucose metabolism than either metrizamide or the new non-ionic dimer iodixanol.

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Section: Discussionmentioning

confidence: 96%

“…Metrizamide, however, was not entirely inert and with increased use, a number of adverse reactions were observed. Most reactions were minor but a small number were more serious such as seizure, cortical blindness and aphasia (6). Although all these reactions were transient there was an obvious need for even safer agents.…”

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confidence: 99%