Neurotoxicity of hexachlorophene in mice: Implications of altered cerebral amino acid profiles

Prasad, G.; Rajendra, Wudayagiri; Indira, K.

doi:10.1007/bf01055820

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…These changes were also compatible with the findings of Prasad et al, (1987b) who have demonstrated increased AM levels in cerebral cortex which were proposed to be involved in the expression of neurologic symptoms in HCP intoxication. Unlike AM the branched chain amino acids (BCM) are selectively excluded by the liver and are predominantely metabolized by the skeletal muscle (Adibi, 1980).…”

Section: Dicussionsupporting

confidence: 86%

Deviations in hepatic amino acid profiles of mouse following repeated hexachlorophene administration

Rajendra

Indira

1988

J. of Env. Sc. & Hlth., Part B

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Effects of repeated administration of hexachlorophene (HCP) on the food consumption, body and liver weights, liver somatic indices and hepatic levels of the free amino acids and amino acid-enzyme activities have been studied. A dose-dependent reduction in body weights and food consumption and increased liver somatic indices suggested a progressive and on toward response to HCP. The concentrations of hepatic free amino acids: phenylalanine, tyrosine, leucine, isoleucine, valine, threonine, asparagine, glutamic acid and glutamine were significantly (p less than 0.001) increased while serine, glycine, taurine and alanine levels were unaffected. The aspartic acid levels showed a conspicuous decrement. The specific activity patterns of the amino acid-enzymes denoted reduced oxidation of amino acids in liver. The abnormal rise in branched chain and aromatic amino acids could be due to the reduced utilization because of the depletion of skeletal muscle mass and hepatic dysfunction in HCP intoxication. A pronounced reduction in aspartic acid levels may deserve consideration in the manifestation of hyperammonemia and neurologic symptoms in HCP intoxication.

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Section: Dicussionsupporting

confidence: 86%

Deviations in hepatic amino acid profiles of mouse following repeated hexachlorophene administration

Rajendra

Indira

1988

J. of Env. Sc. & Hlth., Part B

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Genotoxicity of water extracts from the River Yamuna at Mathura, India

Aleem

Malik

2003

Environmental Toxicology

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Water samples were collected from the River Yamuna at Mathura, India, and concentrated by using XAD resins (Amberlite XAD-4 and XAD-8) and liquid-liquid extraction procedures. The genotoxicities of the extracted water samples were evaluated by the Ames Salmonella/mammalian microsome test, DNA repair of defective mutants, and bacteriophage lambda systems. The results of the Salmonella test demonstrated that the XAD-concentrated water samples had maximum mutagenicity with the TA98 strain, both with and without metabolic activation. The XAD-concentrated water samples collected in the summer showed maximum mutagenic responses compared with those collected in other seasons, whereas the liquid-liquid extracted samples exhibited maximum mutagenic activity during the postmonsoon season. The damage brought about during DNA repair of defective mutants in the presence of XAD-concentrated water samples was found to be remarkably high compared with the liquid-liquid extracted water samples at a dose level of 20 microL/mL of culture. All the mutants invariably exhibited significant decline in their colony-forming units compared with their isogenic wild-type counterparts. Survival was decreased by 86.7% and 65.1% in the polA(-) strain after 6 h of treatment with XAD-concentrated and liquid-liquid extracted water samples, respectively. A significant decrease in the survival of bacteriophage lambda was also observed when treated with test samples. The damage was more pronounced in lexA mutants when the phage was treated with XAD-concentrated samples. The recA, lexA, and polA mutants of E. coli K-12 were found to be sensitive to the test samples, suggesting damage to the DNA of exposed cells as well as to the role of recA(+), lexA(+), and polA(+) genes in coping with the hazardous effect of the pollutants. The results demonstrated substantial genotoxicity and mutagenicity in the water samples tested.

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Hexachlorophene

2016

Meyler's Side Effects of Drugs

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Neurotoxicity of hexachlorophene in mice: Implications of altered cerebral amino acid profiles

Cited by 6 publications

References 17 publications

Deviations in hepatic amino acid profiles of mouse following repeated hexachlorophene administration

Deviations in hepatic amino acid profiles of mouse following repeated hexachlorophene administration

Genotoxicity of water extracts from the River Yamuna at Mathura, India

Hexachlorophene

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