Neurotoxicity of four frequently used nanoparticles: a systematic review to reveal the missing data

Gong, Jia You; Holt, Matthew; Hoet, Peter; Ghosh, Manosij

doi:10.1007/s00204-022-03233-1

Cited by 13 publications

(8 citation statements)

References 99 publications

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“…However, the mechanism of the exposure pathway was still unclear, and more experimental evidence was needed. The dose–effect of nanoparticles on toxicity was obvious …”

Section: Nanometer Materialsmentioning

confidence: 99%

Application of Nanotechnology-Based Products in Stroke

Cai

Sun

Chen

et al. 2023

ACS Chem. Neurosci.

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Stroke is a disease with high disability and high mortality in the world. Due to the existence of the blood-brain barrier (BBB), complex brain structure, and numerous neural signal pathways, the treatment methods are limited, so new drugs and new treatments need to be developed urgently. Thankfully, the advent of nanotechnology offered a new opportunity for biomedical development because of the unique properties of nanoparticles that give them the ability to traverse the BBB and accumulate in relevant regions of the brain. More importantly, nanoparticles could be modified on the surface to meet a variety of specific properties that people need. Some could be used for effective drug delivery, including tissue plasminogen activator (tPA), neuroprotective agents, genes, and cytokines; some nanoparticles were used as contrast agents and biosensors in medical imaging for further diagnosis of stroke; some were used to track target cells for prognosis of stroke; and some were used to detect pathological markers of stroke that appear at different stages. This Review looks at the application and research progress of nanoparticles in the diagnosis and treatment of stroke, hoping to bring some help to researchers.

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“…However, the mechanism of the exposure pathway was still unclear, and more experimental evidence was needed. The dose–effect of nanoparticles on toxicity was obvious …”

Section: Nanometer Materialsmentioning

confidence: 99%

Application of Nanotechnology-Based Products in Stroke

Cai

Sun

Chen

et al. 2023

ACS Chem. Neurosci.

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Section: Environmental Factors With Immunoreactive Potentialmentioning

confidence: 99%

“…In contrast, air pollutants such as PM, a complex air suspension of solid and liquid, organic and inorganic particles, as well as nanoparticles, environmental contaminants of small dimensions (1–100 nm), can negatively alter immune activity and function [23, 18]. In mice, chronic ultrafine PM (PM 2.5 ), diesel exhaust particles, and engineered nanoparticles induced systemic and neuroinflammatory immune responses [4, 23]. In humans, maternal exposure to traffic‐related air pollutants, such as nitrogen oxide, PM, and ozone (O 3 ), has been associated with increased inflammatory cytokine levels in newborns, impairing immune system development and postnatal immune functions [24, 23].…”

Section: Environmental Factors With Immunoreactive Potentialmentioning

confidence: 99%

“…In mice, chronic ultrafine PM (PM 2.5 ), diesel exhaust particles, and engineered nanoparticles induced systemic and neuroinflammatory immune responses [4, 23]. In humans, maternal exposure to traffic‐related air pollutants, such as nitrogen oxide, PM, and ozone (O 3 ), has been associated with increased inflammatory cytokine levels in newborns, impairing immune system development and postnatal immune functions [24, 23]. Further airborne factors with immunoreactive and inflammatory potential comprise cigarette smoke [25], organic agricultural dust [26], and microplastics [27, 28].…”

Section: Environmental Factors With Immunoreactive Potentialmentioning

confidence: 99%

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Asthma and allergic diseases: Cross talk of immune system and environmental factors

2023

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Air pollution and immune-related diseases including allergy and asthma are constantly on the rise worldwide. Thus, a comprehensive investigation of environmentally induced immune regulation is required for a deeper understanding of disease pathogenesis, progression as well as prevention. Here, we summarize the current knowledge on environmental factors such as microbiome or geographical locations with harmful or protective effects for human health and their different routes of exposure. This review comprises a brief outline regarding the latest findings on the interaction of environmental factors with innate and adaptive regulation of the immune system, exemplarily for one protective and one harmful environmental factor, respectively.

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“…NPs can be transported into the brain in different ways, directly inducing neurotoxicity. [18,19] Previous studies believe that NPs are mainly transported into the brain through the BBB, and the existence of NPs can be detected in the blood. [20,21] In addition, NPs transported into the brain across the BBB can be randomly distributed throughout the brain region, with broad effects on brain tissue.…”

Section: Tongue-brain-transported Zno Nps Impaired Synaptic Transmiss...mentioning

confidence: 99%

Tongue−Brain‐Transported ZnO Nanoparticles Induce Abnormal Taste Perception

Chen

Wang

Kang

et al. 2023

Adv Healthcare Materials

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Nanoparticles (NPs) can be transported to the brain, especially through nerves, because of their small size and high biological activity. Previous studies confirmed that zinc oxide (ZnO) NPs can enter the brain through the tongue−brain pathway, but it is unclear whether they will further affect synaptic transmission and brain perception. In this study, it is found that tongue−brain‐transported ZnO NPs can cause a decrease in taste sensitivity and taste aversion learning ability, indicating abnormal taste perception. Moreover, the release of miniature excitatory postsynaptic currents, the frequency of action potential release, and the expression of c‐fos are decreased, suggesting that the synaptic transmission is reduced. To further explore the mechanism, protein chip detection of inflammatory factors is carried out and it is found that neuroinflammation occurs. Importantly, it is found that neuroinflammation originated from neurons. The JAK‐STAT signaling pathway is activated, which inhibits the Neurexin1‐PSD95‐Neurologigin1 pathway and c‐fos expression. Blocking the activation of the JAK‐STAT pathway prevents neuroinflammation and the reduction in Neurexin1‐PSD95‐Neurologigin1. These results indicate that ZnO NPs can be transported by the tongue−brain pathway and lead to abnormal taste perception by neuroinflammation‐induced deficits in synaptic transmission. The study reveals the influence of ZnO NPs on neuronal function and provides a novel mechanism.

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Neurotoxicity of four frequently used nanoparticles: a systematic review to reveal the missing data

Cited by 13 publications

References 99 publications

Application of Nanotechnology-Based Products in Stroke

Application of Nanotechnology-Based Products in Stroke

Asthma and allergic diseases: Cross talk of immune system and environmental factors

Tongue−Brain‐Transported ZnO Nanoparticles Induce Abnormal Taste Perception

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