Neurotoxicity of Copper

Bulcke, Felix; Dringen, Ralf; Scheiber, Ivo F.

doi:10.1007/978-3-319-60189-2_16

Cited by 89 publications

(59 citation statements)

References 252 publications

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“…At the same time, the disturbed bioavailability of copper resulting in deficiency is another feature of AD (Kaden et al 2011), although the mechanisms and the causal relationships of the reduced copper availability in AD are not well understood (Kessler et al 2006;Schafer et al 2007;Klevay 2010;Bost et al 2016;Bulcke et al 2017;Li et al 2017;Bagheri et al 2018;Kardos et al 2018). AD-associated alterations in metal-ion (primarily copper) homeostasis were found in all regions of AD brain tissue (Xu et al 2017), suggesting a pan-cerebral copper deficiency in AD.…”

Section: Neurological Disordersmentioning

confidence: 99%

“…Copper has also been connected to Parkinson's disease, Huntington's disease, and autism spectrum disorder (ASD), although these links are controversial and not well understood. Copper may play a role in the pathogenesis, or copper deficiency may be an indicator of those at risk for Parkinson's (Bulcke et al 2017). Copper accumulation in brains of Huntington's disease patients has been implicated in accelerating disease progression; copper chelators and a reduction in copper in the diet was shown to delay the disease progression in animal models (Bulcke et al 2017).…”

Section: Neurological Disordersmentioning

confidence: 99%

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Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper

Taylor

Tsuji

Garry

et al. 2019

Environmental Management

355

146

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Decades of study indicate that copper oral exposures are typically not a human health concern. Ingesting high levels of soluble copper salts can cause acute gastrointestinal symptoms and, in uncommon cases, liver toxicity in susceptible individuals with repeated exposure. This focused toxicological review evaluated the current literature since the last comprehensive reviews (2007)(2008)(2009)(2010). Our review identified limitations in the existing United States and international guidance for determining an oral reference dose (RfD) for essential metals like copper. Instead, an alternative method using categorical regression analysis to develop an optimal dose that considers deficiency, toxicity, and integrates information from human and animal studies was reviewed for interpreting an oral RfD for copper. We also considered subchronic

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Section: Neurological Disordersmentioning

confidence: 99%

Section: Neurological Disordersmentioning

confidence: 99%

Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper

Taylor

Tsuji

Garry

et al. 2019

Environmental Management

355

146

View full text Add to dashboard Cite

show abstract

“…It has been proven that nanoparticles may cause some degree of damage to the blood-brain barrier leading to increased permeability and facilitating its penetration into the central nervous system (CNS) [185]. Similarly, AgNP and ZnONP toxicity was also associated with the accumulation of nanoparticles in the brain, responsible for some degree of neuroinflammation and neurodegeneration caused by ROS induced CNS injury [186].…”

Section: Neurotoxicitymentioning

confidence: 99%

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

et al. 2020

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Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to a specific receptor in the bacterial cell) which not only makes the development of resistance by bacteria difficult, but also broadens the spectrum of antibacterial activity. As a result, a large majority of metal-based nanoparticles efficacy studies performed so far have shown promising results in both Gram-positive and Gram-negative bacteria. The aim of this review has been a comprehensive discussion of the state of the art on the use of the most relevant types of metal nanoparticles employed as antimicrobial agents. A special emphasis to silver nanoparticles is given, while others (e.g., gold, zinc oxide, copper, and copper oxide nanoparticles) commonly used in antibiotherapy are also reviewed. The novelty of this review relies on the comparative discussion of the different types of metal nanoparticles, their production methods, physicochemical characterization, and pharmacokinetics together with the toxicological risk encountered with the use of different types of nanoparticles as antimicrobial agents. Their added-value in the development of alternative, more effective antibiotics against multi-resistant Gram-negative bacteria has been highlighted.

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“…On the other hand, there is the issue of the toxicity of copper in humans at high doses, described in individuals who accidentally have ingested this metal. 30 The doses used in this study would not present a risk of toxicity in case of accidental intake.…”

Section: Discussionmentioning

confidence: 95%

Efficacy of copper sulphate on Candida albicans on heat-polymerized acrylic resin

et al. 2020

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The ageing of population is increasing, and a great percentage of these patients wear removable prostheses, and can suffer denture stomatitis, a condition that has been associated with candidiasis. Aims: To evaluate in vitro the effectiveness of Copper Sulfate against Candida albicans in samples of heat-polymerized acrylic resin, compared to nystatin, sodium hypochlorite and chlorhexidine. Materials and Methods: Initially, the minimum inhibitory concentration (MIC) of copper sulfate for Candida albicans was determined by microdilution. Then, 54 resin samples were divided into 6 treatment groups corresponding to Nystatin 100.000 UI, Sodium Hypochlorite 0.5%, chlorhexidine 0.12%, Copper Sulfate 4.7µg/ml, Copper Sulfate 9.4µg/ml and physiological saline solution, in which samples were submerged for 6 hours. Resin samples were then washed and cultured on solid media at 37°C for 72 hours. The number of colony-forming units was determined using a Quebec colony counter. The statistical analysis was performed using the Kruskal-Wallis test and the Mann-Whitney U test. Results: Copper sulfate at a concentration of 9.4μg/ml presented a similar effectiveness as the other control products regarding the reduction in the number of colonies of Candida albicans post-treatment. Conclusion: The effectiveness of copper sulfate against Candida albicans on acrylic resin was similar to that of nystatin, sodium hypochlorite and chlorhexidine.Abstract: En las últimas décadas se ha observado un aumento de la población de adultos mayores, de los cuales un gran porcentaje es portador de prótesis removible, y dos tercios pueden sufrir estomatitis subprotésica, enfermedad que es asociada a infecciones como candidiasis. Objetivo: Evaluar la efectividad antimicótica in vitro del sulfato de cobre en placas de resinas acrílicas de termocurado inoculadas con Candida albicans, frente a Nistatina, Hipoclorito de Sodio y Clorhexidina. Material y Métodos: Inicialmente, y mediante microdilución del sulfato de cobre, se determinó la concentración mínima inhibitoria (CMI) para Candida albicans. En la fase experimental, 54 muestras de resina se dividieron en 6 grupos correspondientes a Nistatina 100.000 UI, Hipoclorito 0.5%, Clorhexidina 0.12%, Sulfato de Cu 4.7µg/ml, Sufato de Cu 9.4 µg/ml y suero fisiológico. Las muestras fueron sumergidas en estos agentes por 6 horas, para posteriormente ser lavadas y cultivada en medios solidos a 37°C por 72 horas. Luego se realizó el conteo de unidades formadoras de colonias mediante contador tipo Quebec. El análisis estadístico se realizó mediante la prueba de Kruskal-Wallis y la prueba U de Mann-Whitney. Resultado: El sulfato de cobre a una concentración de 9.4μg/

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Neurotoxicity of Copper

Cited by 89 publications

References 252 publications

Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper

Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

Efficacy of copper sulphate on Candida albicans on heat-polymerized acrylic resin

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