Neurotoxicity of 2-Bromopropane and 1-Bromopropane, Alternative Solvents for Chlorofluorocarbons

Yu, Xiaozhong; Ichihara, Gaku; Kitoh, Junzoh; Xie, Zhenlin; Shibata, Eiji; Kamijima, Michihiro; Takeuchi, Yasuhiro

doi:10.1006/enrs.2000.4226

Cited by 43 publications

(37 citation statements)

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“…61 Yu and colleagues found MCV values slowed considerably and DL values became significantly prolonged as compared to control animals after 4 weeks of exposure to 1-BP at levels of 1000 ppm. 49,62 This same research group noted that the onset of decrease in MCV and prolongation in DL occurred earlier in those rats exposed to 1-BP at 1000 ppm than in those exposed to 2-BP at 1000 ppm. 49 Zhao and colleagues conducted a study in which male rats received daily subcutaneous injections of 1-BP (5 days a week for 4 weeks) at doses reported by the authors to correspond to inhalational exposure levels of 300 and 1000 ppm.…”

Section: Health Hazard Evaluation Report No 99-0260-2906mentioning

confidence: 97%

“…49,62 This same research group noted that the onset of decrease in MCV and prolongation in DL occurred earlier in those rats exposed to 1-BP at 1000 ppm than in those exposed to 2-BP at 1000 ppm. 49 Zhao and colleagues conducted a study in which male rats received daily subcutaneous injections of 1-BP (5 days a week for 4 weeks) at doses reported by the authors to correspond to inhalational exposure levels of 300 and 1000 ppm. 63 Although it is unclear that these injections accurately approximated inhalational exposures, the results of this study also showed slowing of MCV and prolongation of DL.…”

Section: Health Hazard Evaluation Report No 99-0260-2906mentioning

confidence: 97%

“…49,62 In the study by Yu of chronic inhalational toxicity, male rats were either unexposed to 1-BP or were exposed at a dose of 1000 ppm for 8 hours a day for a period up to 7 weeks. (Rats were also exposed to 2-BP at 100 and 1000 ppm in this study.)…”

Section: Limb Strengthmentioning

confidence: 99%

“…41,42,43,44,45,46,47,48 1-BP is currently marketed domestically and is being considered by the Environmental Protection Agency (EPA) as an alternative to chlorofluorocarbons (CFCs), a class of chemicals banned by international agreement for protection of the ozone layer. 49 Workers exposed to 1-BP may be exposed to small (but measurable) quantities of 2-BP since the latter isomer is generated as a contaminant in the manufacture of the former. However, the percentage of 2-BP contamination in neat 1-BP has steadily decreased from 1-2% to 0.1% and below.…”

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confidence: 99%

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Health hazard evaluation report: HETA-99-0260-2906, Marx Industries, Inc., Sawmills, North Carolina.

2003

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This Health Hazard Evaluation (HHE) report and any recommendations made herein are for the specific facility evaluated and may not be universally applicable. Any recommendations made are not to be considered as final statements of NIOSH policy or of any agency or individual involved.Additional HHE reports are available at http://www.cdc.gov/niosh/hhe/reports This Health Hazard Evaluation (HHE) report and any recommendations made herein are for the specific facility evaluated and may not be universally applicable. Any recommendations made are not to be considered as final statements of NIOSH policy or of any agency or individual involved.Additional HHE reports are available at http://www.cdc.gov/niosh/hhe/reports applicable. Any recommendations made are not to be considered as final statements of NIOSH policy or of any agency or individual involved.Additional HHE reports are available at http://www.cdc.gov/niosh/hhe/reports ii PREFACEThe Hazard Evaluations and Technical Assistance Branch (HETAB) of the National Institute for Occupational Safety and Health (NIOSH) conducts field investigations of possible health hazards in the workplace. These investigations are conducted under the authority of Section 20(a)(6) of the Occupational Safety and Health (OSHA) Act of 1970, 29 U.S.C. 669(a)(6) which authorizes the Secretary of Health and Human Services, following a written request from any employer or authorized representative of employees, to determine whether any substance normally found in the place of employment has potentially toxic effects in such concentrations as used or found.HETAB also provides, upon request, technical and consultative assistance to Federal, State, and local agencies; labor; industry; and other groups or individuals to control occupational health hazards and to prevent related trauma and disease. Mention of company names or products does not constitute endorsement by NIOSH. For the purpose of informing affected employees, copies of this report shall be posted by the employer in a prominent place accessible to the employees for a period of 30 calendar days. ACKNOWLEDGMENTS AND AVAILABILITY OF REPORTiv Highlights of the NIOSH Health Hazard Evaluation Evaluation of Exposure to Spray Adhesive (1-bromopropane [1-BP])This Health Hazard Evaluation was requested by the North Carolina Department of Labor to address concerns about possible health problems related to working with a spray adhesive that contains the chemical 1-bromopropane [1-BP]. We also checked to see if Marx employees were exposed to arsenic. What NIOSH Did# We checked the air for 1-BP levels. # We took air, water, hand wipe, and surface dust samples to try to find any arsenic source.# We asked employees to fill out a questionnaire and participate in a medical survey.# We conducted a medical survey to see if exposure to 1-BP at Marx was causing problems with blood counts, nerve problems, and, for men, reproductive problems. What NIOSH Found# Employees on the spray lines were exposed to high levels of 1-BP.# The wall fans near spray tabl...

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Section: Health Hazard Evaluation Report No 99-0260-2906mentioning

confidence: 97%

Section: Health Hazard Evaluation Report No 99-0260-2906mentioning

confidence: 97%

Section: Limb Strengthmentioning

confidence: 99%

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confidence: 99%

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Health hazard evaluation report: HETA-99-0260-2906, Marx Industries, Inc., Sawmills, North Carolina.

2003

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“…Because Korean workers exposed to 2-BP complained of numbness and paralysis in hand muscles, Yu et al [20,26] studied the neurological effects of 2-BP in rats. Nine, 10-week-old male Wistar rats/group (from Shizuoka Laboratory Animal Center) were exposed to filtered air or 100 or 1000 ppm [503 or 5031 mg/m 3 ] 2-BP vapors (99.4% purity) for 8 h per day, 7 days per week, for 12 weeks.…”

Section: Animal Datamentioning

confidence: 99%

NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of 1-bromopropane

2004

Reproductive Toxicology

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PrefaceThe National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences (NIEHS) established the NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) in June 1998. The purpose of the CERHR is to provide timely, unbiased, scientifically sound evaluations of human and experimental evidence for adverse effects on reproduction, including development, caused by agents to which humans may be exposed.2-Bromopropane (2-BP) was nominated by NIOSH and selected for evaluation by the CERHR based primarily on documented evidence of worker exposures and published evidence of reproductive toxicity in both rodents and humans. In the US, 2-BP is a contaminant (<0.1%) of 1-bromopropane which is used in spray adhesives and as a precision cleaner and degreaser. 2-BP may also be used as an intermediate in the synthesis of pharmaceutical dyes and other organic chemicals. In Asia 2-BP has been used as a replacement for chlorofluorocarbons and 1,1,1-trichloroethane.The evaluation of 2-BP was a 4-month effort by a 9-member panel of academic, private, and government scientists that culminated in a public meeting in December 2001. At that meeting, the expert panel reviewed the scientific evidence on 2-BP and reached conclusions ଝ This report is prepared according to the Guidelines for CERHR Panel Members established by NTP/NIEHS. The guidelines are available from the CERHR web site (http://cerhr.niehs.nih.gov/). The format for Expert Panel Reports includes synopses of studies reviewed, followed by an evaluation of the strengths/weaknesses and utility (adequacy) of the study for a CERHR evaluation. Statements and conclusions made under strengths/weaknesses and utility evaluations are those of the Expert Panel and are prepared according to the NTP/NIEHS guidelines. In addition, the panel often makes comments or notes limitations in the synopses of the study. Bold, square brackets are used to enclose such statements. As discussed in the guidelines, square brackets are used to enclose key items of information not provided in a publication, limitations noted in the study, conclusions that differ from authors, and conversions or analyses of data conducted by the panel.Correspondence to shelby@niehs.nih.gov (M. Shelby). regarding its potential effects on human reproduction. The background information on 2-BP and findings of the expert panel are contained within this report. The Expert Panel Report on 2-bromopropane is intended to (1) interpret the strength of scientific evidence that a given exposure or exposure circumstance may pose a hazard to reproduction and the health and welfare of children; (2) provide objective and scientifically thorough assessments of the scientific evidence that adverse reproductive/developmental health effects are associated with exposure to specific chemicals or classes of chemicals, including descriptions of any uncertainties that would diminish confidence in assessment of risks; and (3) identify knowledge gaps to help establish research and testing priorities. Staff ...

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1‐Brompropan [BAT Value Documentation in German language, 2011]

Göen¹

2013

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte), Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA), Biologische Leitwerte (BLW) und Biologische Arbeitsstoff‐Referenzwerte (BAR) , 18. Lieferung, Ausgabe 2011 Der Artikel enthält folgende Kapitel: Metabolismus und Toxikokinetik Kritische Toxizität Belastung und Beanspruchung Beziehung zwischen äußerer und innerer Belastung Beziehung zwischen innerer Belastung und Beanspruchung Auswahl der Indikatoren Untersuchungsmethoden Hintergrundbelastung Evaluierung Interpretation

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Neurotoxicity of 2-Bromopropane and 1-Bromopropane, Alternative Solvents for Chlorofluorocarbons

Cited by 43 publications

References 8 publications

Health hazard evaluation report: HETA-99-0260-2906, Marx Industries, Inc., Sawmills, North Carolina.

Health hazard evaluation report: HETA-99-0260-2906, Marx Industries, Inc., Sawmills, North Carolina.

NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of 1-bromopropane

1‐Brompropan [BAT Value Documentation in German language, 2011]

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