Neurotoxicity Due to Antimalarial Therapy Associated with Misdiagnosis of Malaria

Franco‐Paredes, Carlos; Dismukes, Roberta; Nicolls, Deborah; Kozarsky, Phyllis E.

doi:10.1086/430180

Cited by 31 publications

(10 citation statements)

References 7 publications

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“…Brainstem areas typically affected include: the reticular formation, with autonomic control centers affected, the vestibular system, the auditory system, with the trapezoid nucleus, believed important in the localization of sound, especially affected, and the red nucleus, which plays a role in coordination [88][89][90][91][92][93][94].The available human clinical evidence supports currently available artemisinin derivatives, alone or in combination with partner drugs, as being neurotoxic. The evidence comes from audiometric studies that conducted pre-exposure baseline measurements [95][96][97], case reports [94,[98][99][100], delayed coma recovery times in cerebral malaria patients [101], and excess mortality in subjects with late hypoglycaemia treated with intravenous artesunate [102].…”

Section: Information On Toxicitymentioning

confidence: 99%

“…The available human clinical evidence supports currently available artemisinin derivatives, alone or in combination with partner drugs, as being neurotoxic. The evidence comes from audiometric studies that conducted pre‐exposure baseline measurements [95–97], case reports [94,98–100], delayed coma recovery times in cerebral malaria patients [101], and excess mortality in subjects with late hypoglycaemia treated with intravenous artesunate [102].…”

Section: Introductionmentioning

confidence: 99%

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Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

Na‐Bangchang¹,

Karbwang

2009

Fundamemntal Clinical Pharma

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Antimalarial drugs have played a mainstream role in controlling the spread of malaria through the treatment of patients infected with the plasmodial parasites and controlling its transmissibility. The inadequate armory of drugs in widespread use for the treatment of malaria, development of strains resistant to currently used antimalarials, and the lack of affordable new drugs are the limiting factors in the fight against malaria. In addition, other problems with some existing agents include unfavorable pharmacokinetic properties and adverse effects/toxicity. These factors underscore the continuing need of research for new classes of antimalarial agents, and a re-examination of the existing antimalarial drugs that may be effective against resistant strains. In recent years, major advances have been made in the pharmacology of several antimalarial drugs both in pharmacokinetics and pharmacodynamics aspects. These include the design, development, and optimization of appropriate dosage regimens of antimalarials, basic knowledge in metabolic pathways of key antimalarials, as well as the elucidation of mechanisms of action and resistance of antimalarials. Pharmacologists have been working in close collaboration with scientists in other disciplines of science/biomedical sciences for more understanding on the biology of the parasite, host, in order to exploit rational design of drugs. Multiple general approaches to the identification of new antimalarials are being pursued at this time. All should be implemented in parallel with focus on the rational development of new agents directed against newly identified parasite targets. With major advances in our understanding of malaria parasite biology coupled with the completion of the malaria genome, has presented exciting opportunities for target-based antimalarial drug discovery.

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Section: Information On Toxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

Na‐Bangchang¹,

Karbwang

2009

Fundamemntal Clinical Pharma

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“…Five cases have been reported that suggest episodes of neurotoxicity due to multiple courses of ARTs therapy (Elias et al, 1999;Franco-Paredes et al, 2005;Haq et al, 2009;Miller & Panosian 1997;Panossian et al, 2005). These reports may constitute evidence of a causal association that merits further investigation.…”

mentioning

confidence: 91%

Pharmacokinetic (PK) and Pharmacodynamic Profiles of Artemisinin Derivatives Influence Drug Neurotoxicity in Animals

Li¹,

Hickman²

2012

Readings in Advanced Pharmacokinetics - Theory, Methods and Applications

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“…The letter was in response to a reply by Newton et al [2] to a case reported by Franco-Paredes et al [3]. This letter makes reference to our congress presentation [4], but Toovey has changed the title of our abstract and has overstretched our data.…”

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confidence: 99%

Neurotoxicity of Artemisinin Derivatives

Adjei

Goka

Kurtzhals

2006

Clinical Infectious Diseases

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Neurotoxicity Due to Antimalarial Therapy Associated with Misdiagnosis of Malaria

Cited by 31 publications

References 7 publications

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

Pharmacokinetic (PK) and Pharmacodynamic Profiles of Artemisinin Derivatives Influence Drug Neurotoxicity in Animals

Neurotoxicity of Artemisinin Derivatives

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