“…Interestingly, we did not observe barrel rotations previously in adult mice as part of TMDT‐induced seizure syndrome (Shakarjian et al, ). In rats, barrel rotations typically represent a hallmark of hypoglycemia‐associated convulsions but occur also following application of quinolinic acid, scorpion venom poisoning or intracerebroventricular administration of neuropeptides (somatostatin, vasopressin, endothelin‐1) and are considered a severe seizure behavior (Gastaut et al, ; Marrannes and Wauquier, ; Chew et al, ; Nencioni et al, ; Velísek et al, ). Regional brain glucose utilization studies suggest that barrel rotations mainly involve brainstem structures, that is, inferior colliculus, pontine nuclei, and vestibulo‐cerebellar pathways (Chew et al, ; Doriat et al, ; Wurpel et al, ).…”