1974
DOI: 10.1007/bf01921600
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Neurotoxic effect of leptophos

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1978
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Cited by 70 publications
(4 citation statements)
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“…It is reasonable to suppose that the hydrocarbon radicals of the aliphatic and aromatic deriva tives interact with the same part of the active center surface. A very interesting correlation was obtained between the chemical struc ture and delayed neurotoxic potency of methyl phenylphosphonothioate esters (48,69,91,157,(172)(173)(174)(175)(176)(177). The unsubstituted phenyl ester did not cause delayed neurotoxicity at a single 500 mglkg oral dose.…”
Section: Aliphatic Phosphorus Estersmentioning
confidence: 92%
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“…It is reasonable to suppose that the hydrocarbon radicals of the aliphatic and aromatic deriva tives interact with the same part of the active center surface. A very interesting correlation was obtained between the chemical struc ture and delayed neurotoxic potency of methyl phenylphosphonothioate esters (48,69,91,157,(172)(173)(174)(175)(176)(177). The unsubstituted phenyl ester did not cause delayed neurotoxicity at a single 500 mglkg oral dose.…”
Section: Aliphatic Phosphorus Estersmentioning
confidence: 92%
“…, lambs (46), sheep (47), and water buffalo (48), are susceptible. Rats, mice (14), rabbits, guinea pigs (15), hamsters, and gerbils2 did not show consistent delayed response to TOCP, although the acute effects were severe.…”
Section: The Development Of An Experimental Model Of Delayed Neurotoxmentioning
confidence: 99%
“…Recently, the phenylphosphonothioate insecticide leptophos has been implicated in the poisoning and paralysis of some workers in Texas (4). Leptophos produces delayed neurotoxicity in farm animals and chickens (5)(6)(7)(8)(9). A photodegradation product of this compound, desbromoleptophos (DBL), was reported to cause delayed neurotoxicity in chickens (10).…”
mentioning
confidence: 99%
“…These therapeutic effects are pre-sumably mediated in part through actions on the central nervous system (CNS) since high-affinity, stereospecific, and saturable binding sites for benzodiazepines have been identified through-out the CNS both in vitro (2,3) and in vivo (4). Several substances isolated from the CNS compete with tritiated benzodiazepines for CNS receptor sites (5). These endogenous substances have been identified as the purine hypoxanthine and its nucleoside inosine (6), both of which are synthesized de novo in neuronal tissue (7).…”
mentioning
confidence: 99%