Neurotoxic Agents and Peripheral Neuropathy

Abstract

Neurotoxicity may develop with exposure to various substances such as antibiotics, chemotherapeutics, heavy metals, and solvents. Some plants and fungi are also known to be neurotoxic. Neurotoxicity can develop acutely within hours, or it can develop as a result of exposure for years. Neurotoxicity can be presented with central or peripheral nervous system findings such as neurobehavioral symptoms, extrapyramidal signs, peripheral neuropathy. Peripheral nerve fibers are affected in different ways by neurotoxicant injury. The pattern of injury depends on the target structure involved. The focus of this chapter includes signs, symptoms, pathophysiology, and treatment options of neurotoxicity.

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“…Chronic and acute exposure results in nervous system disorders, immune system disorders, cancer, skin lesions, birth malformations, vascular damage, and kidney and G.I. dysfunction (Eskut & Koskderelioglu, 2021). Heavy metals result in neurotoxicity using oxidative stress, dysregulation of cell signaling, cell membrane disruption, and impairment of neurotransmission (Eskut & Koskderelioglu, 2021).…”

“…dysfunction (Eskut & Koskderelioglu, 2021). Heavy metals result in neurotoxicity using oxidative stress, dysregulation of cell signaling, cell membrane disruption, and impairment of neurotransmission (Eskut & Koskderelioglu, 2021).…”