Neuroticism and Fatigue 3 Months After Ischemic Stroke

Lau, Chieh Grace; Tang, Wai Kwong; Liu, Xiang Xin; Liang, Hua; Liang, Yan; Mok, Vincent; Wong, Adrian; Ungvári, Gábor S.; Kutlubaev, Mansur A.; Wong, Ka Sing

doi:10.1016/j.apmr.2016.08.480

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…In addition to symptoms that may vary over time, people differ in their stable proneness for negative affect. Trait neuroticism as a five-factor personality trait has been extensively implicated as a possible precipitating mechanism in relation to fatigue in other populations, in epidemiological studies [ 30 , 31 , 32 , 33 ] and in mild TBI [ 34 ]. Merz et al [ 34 ] also found negative associations between fatigue and trait agreeableness, conscientiousness and extraversion in patients with mild TBI.…”

Section: Introductionmentioning

confidence: 99%

Impact of Somatic Vulnerability, Psychosocial Robustness and Injury-Related Factors on Fatigue following Traumatic Brain Injury—A Cross-Sectional Study

Løke

Anđelić

Helseth

et al. 2022

JCM

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Fatigue is a common symptom after traumatic brain injuries (TBI) and a crucial target of rehabilitation. The subjective and multifactorial nature of fatigue necessitates a biopsychosocial approach in understanding the mechanisms involved in its development. The aim of this study is to provide a comprehensive exploration of factors relevant to identification and rehabilitation of fatigue following TBI. Ninety-six patients with TBI and confirmed intracranial injuries were assessed on average 200 days post-injury with regard to injury-related factors, several patient-reported outcome measures (PROMS) of fatigue, neuropsychological measures, and PROMS of implicated biopsychosocial mechanisms. Factor analytic approaches yielded three underlying factors, termed Psychosocial Robustness, Somatic Vulnerability and Injury Severity. All three dimensions were significantly associated with fatigue in multiple regression analyses and explained 44.2% of variance in fatigue. Post hoc analyses examined univariate contributions of the associations between the factors and fatigue to illuminate the relative contributions of each biopsychosocial variable. Implications for clinical practice and future research are discussed.

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Section: Introductionmentioning

confidence: 99%

Impact of Somatic Vulnerability, Psychosocial Robustness and Injury-Related Factors on Fatigue following Traumatic Brain Injury—A Cross-Sectional Study

Løke

Anđelić

Helseth

et al. 2022

JCM

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“…Given that neuroticism, which encompasses strong negative affect and social inhibition, may increase in response to traumatic events [54], it may be of more interest after a stroke has occurred [55,56]. Indeed, high neuroticism has been linked with decreased QoL after stroke, fewer health promoting behaviours, and increased risks of post-stroke depression, fatigue and apathy [17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…For example, neuroticism and individual facets of this trait have been associated with an increased risk for post-stroke depression and an overall reduced QoL [17,18]. Additionally, stroke survivors with a strong degree of neuroticism have higher levels of fatigue and score lower on the Barthel scale measuring performance in activities of daily living [19]. On the other hand, low extraversion has been associated with an increased post-stroke apathy [18].…”

Section: Introductionmentioning

confidence: 99%

Association of Diligence and Sociability with Stroke: A UK Biobank Study on Personality Proxies

Ruijter¹,

Dahlén²,

Rukh³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: There is a growing interest in how personality may be related to the risk of developing disease. Associations between personality and stroke have so far only been studied in relation to stroke mortality. However, many stroke survivors suffer severe impairment of quality of life due to sequelae such as aphasia, hemiparesis, depression and anxiety. In this study we assess the association between personality and risk of stroke, regardless of mortality. Methods: Using self-reported data on psychological factors, mental health and social support, proxies for the Big Five personality traits were developed for 482,535 participants in the UK Biobank. Logistic regression and Cox proportional hazard models, with 95% confidence intervals (CI), were used to estimate odds ratios (OR) and hazard ratios (HR) between each personality trait and stroke prevalence (N = 6793) and incidence (N = 3312), respectively. Models were adjusted for demographic, health-related, and lifestyle factors. Results: Diligence and sociability were associated with a lower risk of stroke incidence in the fully adjusted model (respectively: [HR = 0.92; 95% CI = (0.88, 0.96)], [HR = 0.93; 95% CI = (0.89, 0.97)]). However, nervousness, curiosity and warmth were not significantly associated with a risk of stroke incidence. Conclusions: Individuals with higher levels of diligence and sociability may be at a reduced risk of developing stroke. With respect to the debated role of neuroticism in relation to cardiovascular disease, we did not find evidence of an association between nervousness and risk of developing stroke.

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“…There is an ongoing discussion about the cause of PSF and the factors that perpetuate it. Literature shows that the presence of biological factors such as leucoaraiosis ( 47 ), depression and anxiety ( 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ), pain ( 47 , 48 , 57 ), sleep disturbances ( 49 , 52 , 53 ), external locus of control ( 54 ), neuroticism ( 50 ) and inadequate coping style ( 59 ) are related to PSF. Higher functional disability levels and stroke severity ( 46 , 49 , 52 , 55 , 58 ), lower physical activity before and after stroke ( 55 , 56 ), use of sedative medication ( 55 ) and prestroke fatigue ( 48 , 52 , 55 ) also seem to play an important role.…”

Section: Poststroke Fatiguementioning

confidence: 99%

Pituitary dysfunction and association with fatigue in stroke and other acute brain injury

Booij

Gaykema

Kuijpers

et al. 2018

Endocrine Connections

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BackgroundPoststroke fatigue (PSF) is a highly prevalent and debilitating condition. However, the etiology remains incompletely understood. Literature suggests the co-prevalence of pituitary dysfunction (PD) with stroke, and the question raises whether this could be a contributing factor to the development of PSF. This study reviews the prevalence of PD after stroke and other acquired brain injuries and its association with fatigue.SummaryWe performed a bibliographic literature search of MEDLINE and EMBASE databases for English language studies on PD in adult patients with stroke, traumatic brain injury (TBI) or aneurysmatic subarachnoid hemorrhage (aSAH). Forty-two articles were selected for review. Up to 82% of patients were found to have any degree of PD after stroke. Growth hormone deficiency was most commonly found. In aSAH and TBI, prevalences up to 49.3% were reported. However, data differed widely between studies, mostly due to methodological differences including the diagnostic methods used to define PD and the focus on the acute or chronic phase. Data on PD and outcome after stroke, aSAH and TBI are conflicting. No studies were found investigating the association between PD and PSF. Data on the association between PD and fatigue after aSAH and TBI were scarce and conflicting, and fatigue is rarely been investigated as a primary end point.Key messagesData according to the prevalence of PD after stroke and other acquired brain injury suggest a high prevalence of PD after these conditions. However, the clinical relevance and especially the association with fatigue need to be established.

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Neuroticism and Fatigue 3 Months After Ischemic Stroke

Cited by 10 publications

References 43 publications

Impact of Somatic Vulnerability, Psychosocial Robustness and Injury-Related Factors on Fatigue following Traumatic Brain Injury—A Cross-Sectional Study

Impact of Somatic Vulnerability, Psychosocial Robustness and Injury-Related Factors on Fatigue following Traumatic Brain Injury—A Cross-Sectional Study

Association of Diligence and Sociability with Stroke: A UK Biobank Study on Personality Proxies

Pituitary dysfunction and association with fatigue in stroke and other acute brain injury

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