Neurotherapeutic potential of kolaviron on neurotransmitter dysregulation, excitotoxicity, mitochondrial electron transport chain dysfunction and redox imbalance in 2-VO brain ischemia/reperfusion injury

Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals

“…Kolaviron is able to reverse mitochondrial electron transport chain dysfunction after brain ischemia/reperfusion injury. In this sense, authors conclude that “kolaviron … is a promising candidate for drug development against stroke” [67]. What remains to be established are the details of the mode of action of kolaviron, for instance, which is the targeted mitochondrial complex: I, II, III or IV.…”

Prophylaxis with a multicomponent nutraceutical abates transient cerebral ischemia/reperfusion injury

“…Animals were positioned on a bar, inclined at angle 60° from the platform. Animals that readily traverse beam, demonstrate mild impairment, moderate impairment, severe impairment and complete inability to walk on the beam were scored 0, 1, 2, 3, and 4, respectively (Aggarwal, Gaur, & Kumar, 2010; Ojo et al., 2019; Sunil et al., 2011).…”

“…Rats were required to balance on an elevated beam. The animals were positioned on the center of the beam for a maximum of 60 s. The performance was assessed with a score ranging from 0 to 6 (Akinmoladun et al., 2018; Jin, Wu, Oh, Kim, & Shin, 2010; Ojo et al., 2019; Singh & Chopra, 2013).…”

Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway

“…I/R injury of limbs is a complex cascade reaction, which is currently considered to be related to the production of oxygen free radicals [ 3 ], calcium overload [ 4 ], neutrophils and inflammatory factors [ 5 ], activation of Kupffer cells [ 6 ], microcirculation disorders [ 7 ], energy metabolism disorders [ 8 ], and cell apoptosis [ 9 ]. It is confirmed that the mechanism of limb I/R injury to distant tissues and organs is closely related to oxygen free radicals and polymorphonuclear neutrophil (PMN).…”