Neurotherapeutic Effects of Bee Venom in a Rotenone-Induced Mouse Model of Parkinson’s Disease

Rakha, Miran; Tawfiq, Rasha A.; Sadek, Mona M A Al; Anwer, Mehwish; Salama, Salma; Mohamed, Abdullah; El-Hendy, M. G.; El-Said, Sh. E.; Ahmed, Nagla Mohammed; Mekawi, K. S.; El-Aziz, A. M. Abd; Elmazar, Mohamed M.

doi:10.1007/s11062-019-09777-w

Cited by 11 publications

(10 citation statements)

References 64 publications

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“…Our results demonstrated increased inflammatory response marked with elevated levels of proinflammatory cytokines IL-1β and TNF-α in both the hippocampus and the striatum of rats administered reserpine-alone. These results are in agreement with other studies reported increased neuroinflammatory markers and oxidative stress in different experimental models of PD 38 , 41 – 43 . Increased inflammatory responses, combined with T cell infiltration into the brain and activation of microglial cell, have been shown to produce an excess of pro-inflammatory cytokines, causing mitochondrial dysfunction and the production of reactive oxygen species (ROS), which aggravate nerve damage in PD 42 , 44 , 45 .…”

Section: Discussionsupporting

confidence: 94%

“…The observed elevation of NE in our results could be a side consequence of elevated dopamine, the main precursor for norepinephrine synthesis. This is consistent with previous studies reported the restoration of dopamine levels in the hippocampus and striatum in various rat models of PD 34 , 38 . In a rotenone model of PD in rats, the pharmacological effects of BV and DA-nanoparticles were previously demonstrated to improve motor function 38 .…”

Section: Discussionsupporting

confidence: 94%

“…This is consistent with previous studies reported the restoration of dopamine levels in the hippocampus and striatum in various rat models of PD 34 , 38 . In a rotenone model of PD in rats, the pharmacological effects of BV and DA-nanoparticles were previously demonstrated to improve motor function 38 . Furthermore, BV acupuncture was found in another study to reverse the depletion of both dopamine and norepinephrine in mice after rotenone intoxication 49 .…”

Section: Discussionsupporting

confidence: 94%

“…In the current study, reserpine provoked a neurotransmitters imbalance in the striatum and hippocampus, as demonstarted by monoamines depletion, elevated the levels of excitatory amino acids (Glu and His), diminished inhibitory amino acids (GABA and Arg), and decreased levels of BDNF. These observed imbalances in neurotransmitters and the brain derived neurotropic factor have previously been demonstarted to cause akinesia and paralysis syndrome in rats, which is analogous to human PD 38 , 39 .…”

Section: Discussionmentioning

confidence: 88%

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Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson’s disease rat model

Ahmed-Farid

Taha

Bakeer

et al. 2021

Sci Rep

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Parkinson’s disease (PD) is a progressive chronic neurodegenerative condition characterized by the loss of dopaminergic neurons within the substantia nigra. Current PD therapeutic strategies are mainly symptomatic and can lead to motor complications overtime. As a result, alternative medicine may provide an effective adjuvant treatment for PD as an addition to or as a replacement of the conventional therapies. The aim of this work was to evaluate the effects of Bee Venom (BV) and dopamine (DA)-loaded nanoparticles in a reserpine-induced animal model of PD. After inducing PD with reserpine injection, different groups of male rats were treated with L-Dopa, BV, DA-nanoparticles. Our findings showed that BV and DA-nanoparticles administration restored monoamines, balanced glutamate/GABA levels, halted DNA fragmentation, decreased pro-inflammatory mediators (IL-1β and TNF-α), and elevated anti-inflammatory mediators (PON1) and neurotropic factor (BDNF) levels in comparison with conventional therapy of PD. Furthermore, in a reserpine-induced PD rat model, the ameliorative effects of BV were significantly superior to that of DA-nanoparticles. These findings imply that BV and DA-nanoparticles could be useful as adjuvant treatments for PD.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 88%

See 2 more Smart Citations

Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson’s disease rat model

Ahmed-Farid

Taha

Bakeer

et al. 2021

Sci Rep

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“…One of the promising applications of HBV is Parkinson’s disease 29 . HBV is a mixture of neuroactive molecules and the observed beneficial effects in the treatment of Parkinson’s disease may result from synergic action of its components, including apamin, melittin, phospholipase A2, and dopamine 73 – 75 . What is interesting, the current paper shows that HBV contains not only dopamine but also L-Dopa, a precursor of dopamine (Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Identification and quantification of honeybee venom constituents by multiplatform metabolomics

Klupczynska

Plewa

Dereziński

et al. 2020

Sci Rep

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Honeybee (Apis mellifera) venom (HBV) has been a subject of extensive proteomics research; however, scarce information on its metabolite composition can be found in the literature. The aim of the study was to identify and quantify the metabolites present in HBV. To gain the highest metabolite coverage, three different mass spectrometry (MS)-based methodologies were applied. In the first step, untargeted metabolomics was used, which employed high-resolution, accurate-mass Orbitrap MS. It allowed obtaining a broad overview of HBV metabolic components. Then, two targeted metabolomics approaches, which employed triple quadrupole MS, were applied to quantify metabolites in HBV samples. The untargeted metabolomics not only confirmed the presence of amines, amino acids, carbohydrates, and organic acids in HBV, but also provided information on venom components from other metabolite classes (e.g., nucleosides, alcohols, purine and pyrimidine derivatives). The combination of three MS-based metabolomics platforms facilitated the identification of 214 metabolites in HBV samples, among which 138 were quantified. The obtaining of the wide free amino acid profiles of HBV is one of the project’s achievements. Our study contributed significantly to broadening the knowledge about HBV composition and should be continued to obtain the most comprehensive metabolite profile of HBV.

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Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine

et al. 2023

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Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide and represents a challenge for clinicians. The present study aims to investigate the effects of cerebrolysin and/or lithium on the behavioral, neurochemical and histopathological alterations induced by reserpine as a model of PD. The rats were divided into control and reserpine-induced PD model groups. The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium. Treatment with cerebrolysin and/or lithium ameliorated most of the alterations in oxidative stress parameters, acetylcholinesterase and monoamines in the striatum and midbrain of reserpine-induced PD model. It also ameliorated the changes in nuclear factor-kappa and improved the histopathological picture induced by reserpine. It could be suggested that cerebrolysin and/or lithium showed promising therapeutic potential against the variations induced in the reserpine model of PD. However, the ameliorating effects of lithium on the neurochemical, histopathological and behavioral alterations induced by reserpine were more prominent than those of cerebrolysin alone or combined with lithium. It can be concluded that the antioxidant and anti-inflammatory effects of both drugs played a significant role in their therapeutic potency.

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Neurotherapeutic Effects of Bee Venom in a Rotenone-Induced Mouse Model of Parkinson’s Disease

Cited by 11 publications

References 64 publications

Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson’s disease rat model

Effects of bee venom and dopamine-loaded nanoparticles on reserpine-induced Parkinson’s disease rat model

Identification and quantification of honeybee venom constituents by multiplatform metabolomics

Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine

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