Neurothekeoma of the Hand

Bhaskar, AA; Kanvinde, R.

doi:10.1054/jhsb.1999.0249

Cited by 15 publications

(7 citation statements)

References 8 publications

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“…3,6,7,8,13,17,24,29,32 All 40 tumors in our series tested for S-100 protein were unequivocally positive. We think that neurothekeoma, as presently defined and diagnosed, is a ''mixed bag'' of unrelated tumors.…”

Section: Discussionmentioning

confidence: 68%

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Nerve Sheath Myxoma

Fetsch

Laskin²,

Miettinen³

2005

American Journal of Surgical Pathology

158

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This report describes the clinicopathologic findings in 57 cases of nerve sheath myxoma. Our study group included 34 males and 23 females, ranging from 8 to 72 years of age at the time of their first surgical procedure (mean, 36 years; median, 34 years). The patients typically presented with solitary, superficial, multinodular masses in the 0.5- to 2.5-cm size range. Eighty-six percent of cases occurred in the extremities, with the most common locations being the hand/fingers (n = 22), knee/pretibial region (n = 10), and ankle/foot (n = 7). Only 7 cases (12.3%) involved the trunk or head and neck region. The tumors were generally slow growing, and often, they were present for many years before surgical resection was sought. In the majority of instances, the lesions were painless. Histologically, the tumors involved the dermis and/or subcutis, and they formed distinct multinodular/multilobular masses with abundant myxoid matrix and a peripheral fibrous border. All cases had small epithelioid Schwann cells in corded, nested, and/or syncytial-like aggregates, a variable number of Schwann cells with a ring-like appearance, and scattered spindled and stellate-shaped Schwann cells. These cells often had cytoplasmic-nuclear invaginations, and they were immunoreactive for S-100 protein, glial fibrillary acidic protein, neuron specific enolase, and CD57. They were also bordered by collagen IV. Epithelial membrane antigen-positive perineurial cells were typically present in small numbers, primarily in the fibrous tissue directly adjacent to the myxoid nodules. CD34-positive intraneural fibroblasts were generally sparse. Mitotic figures were uncommon. All cases were initially managed by simple excision, and in almost all instances, tumor extended to the tissue edge. Follow-up information is available for 34 patients (follow-up range, 8 months to 28 years; median follow-up interval, 14 years 3 months). Sixteen patients (47%) had one (n = 11) or more (n = 5) local recurrence of their tumor, and 2 additional patients had findings suspicious for a recurrence. Nerve sheath myxomas are morphologically distinct peripheral nerve sheath tumors with a peak incidence in the fourth decade of life and a strong predilection for the extremities. These tumors have a relatively high local recurrence rate when managed by simple local excision. They appear to be unrelated to so-called cellular and mixed-type neurothekeomas.

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Section: Discussionmentioning

confidence: 68%

“…3,7,8,13,17,22,24,29,32 This neoplasm is, without doubt, a peripheral nerve sheath tumor. 3,7,8,13,17,22,24,29,32 This neoplasm is, without doubt, a peripheral nerve sheath tumor.…”

Section: Discussionmentioning

confidence: 97%

Nerve Sheath Myxoma

Fetsch

Laskin²,

Miettinen³

2005

American Journal of Surgical Pathology

158

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“…5 O tratamento indicado é resseção cirúrgica, completa, da lesão e parece ser o tratamento definitivo, sem que cause lesão neurológica. [6][7][8][9][10] A resseção incompleta leva a recidiva e invasão local. 5 Uma vez que os neurotequeomas do tipo mixoide e celular são lesões benignas, não há registros de metastização e esse tipo de lesão não beneficia de radioterapia ou quimioterapia adjuvante.…”

Section: Discussionunclassified

Neurotequeoma intraósseo da mão de um jovem de 16 anos

et al. 2019

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ResumoOs tumores dos tecidos moles são raros em idade pediátrica. Descrito pela primeira vez 1969 como um mixoma da bainha nervosa, o neurotequeoma é uma lesão tumoral benigna com presumível origem na bainha nervosa. Ocorre maioritariamente em crianças do sexo feminino e apresenta-se como uma massa de crescimento lento, subcutânea, assintomática e sem alteração da pigmentação local. Localiza-se predominantemente na cabeça, no pescoço, e nas extremidades dos membros superiores. Os autores apresentam um caso clínico de um jovem de 16 anos do sexo masculino com massa tumoral com origem na bainha nervosa no 4° metacarpo esquerdo, intraóssea e recidivada após ressecção cirúrgica 2 anos antes do estudo. Foi feita ressecção marginal da massa tumoral localizada sobre a região distal do quarto metacarpo e curetagem da falange proximal e preenchimento com enxerto ósseo autólogo corticoesponjoso. O paciente apresentou uma evolução clínica pós-operatória favorável, sem queixas álgicas e sem limitações da mobilidade dos dedos da mão. Radiologicamente, foi observado preenchimento trabecular progressivo da falange proximal do quarto metacarpo. Aos 17 meses de seguimento, o paciente se encontra assintomático e não apresenta quaisquer sinais de recidiva. Com a descrição deste caso, os autores pretendem aumentar a familiaridade com essa rara patologia, seu diagnóstico e tratamento.

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“…[6] The myxoid type is characterized by a high degree of myxomatous changes, low cellularity with scattered spindle cells, and is well circumscribed. There may also be multinucleated giant cells and the lesions characteristically stain positively for S-100, collagen type IV, and nerve growth factor receptor but are negative for epithelial membrane antigen or markers of histiocytic differentiation.…”

Section: Discussionmentioning

confidence: 99%