Neurotensin serum levels and skin gene expression are increased in atopic dermatitis

Vasiadi, Magdalini; Mondolfi, Alberto Paniz; Alysandratos, Konstantinos–Dionysios; Therianou, Anastasia; Katsarou-Katsari, Alexandra; Petrakopoulou, Theodora; Theoharidis, A; Miniati, Alexandra; Theoharides, Theoharis C.

doi:10.1111/bjd.12413

Cited by 12 publications

(13 citation statements)

References 16 publications

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“…including visceral NT-secreting neuroendocrine tumors (neurotensinomas) (Calhoun et al, 2003), gastrointestinal motor abnormalities (Bardella et al, 2000), inflammatory dermatological disorders (Vasiadi et al, 2012(Vasiadi et al, , 2013, neurological disorders (Schimpff et al, 2001), psychiatric disease (Angelidou et al, 2010), and acute sympatho-adrenal activation in shock (Piliponsky et al, 2008) or neonatal asphyxia (Liu et al, 2007). Furthermore, high blood plasma levels of NT precursor (proneurotensin) have been revealed in morbidly obese subjects after bariatric surgery (ChristCrain et al 2006) or gastric bypass operation (Holdstock et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Emerging role of neurotensin in regulation of the cardiovascular system

Osadchii

2015

European Journal of Pharmacology

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Section: Discussionmentioning

confidence: 99%

Emerging role of neurotensin in regulation of the cardiovascular system

Osadchii

2015

European Journal of Pharmacology

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“…In addition to IgE-mediated allergic reactions, MCs also participate in innate and acquired immunity Sismanopoulos et al, 2012), autoimmunity (Rottem and Mekori, 2005), and inflammation (Theoharides et al, 2007). In particular, MCs play a crucial role in the pathogenesis of AD (Vasiadi et al, 2013), psoriasis , rheumatoid arthritis (Askenase, 2003;Kritas et al, 2013), multiple sclerosis (MS) (Karagkouni et al, 2013), and autism (Theoharides, 2013), possibly through the "selective" release of mediators (Theoharides et al, 2007).…”

Section: Functional and Pathologic Features Of Il-33 In Allergic Disementioning

confidence: 99%

Targeting IL-33 in Autoimmunity and Inflammation

Theoharides

Petra

Taracanova

et al. 2015

J Pharmacol Exp Ther

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“…The only histological abnormalities considered acceptable were mild superficial chronic gastritis or mild reflux esophagitis, outcomes that were also found in some CD patients (2/9). Moreover, in order to avoid any confounding factors, all subjects enrolled in this study were previously selected according to medical history to exclude any allergic, inflammatory, neoplastic, or neurologic conditions, in light of the possible involvement of NT in these diseases [27,28].…”

Section: Discussionmentioning

confidence: 99%

Fasting Neurotensin Levels in Pediatric Celiac Disease Compared with a Control Cohort

Iorfida

Montuori

Trovato

et al. 2020

Gastroenterology Research and Practice

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Background and Aims. Neurotensin (NT) is a gut hormone secreted by specific endocrine cells scattered throughout the epithelial layer of the small intestine, which has been identified as an important mediator in several gastrointestinal functions and disease conditions. Its potential involvement in celiac disease (CD) has been investigated, but there are conflicting findings. The aim of this study was to evaluate serum NT levels in children with CD at diagnosis, compared to a control group, and to investigate whether NT correlated in CD patients with symptoms, antibody response, and intestinal mucosal damage. Materials and Methods. Children (1-16 years old) undergoing gastrointestinal endoscopy for CD or for other clinical reasons were included in this study. Patients with CD diagnosed according to the 2012 European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines without biopsy were also recruited. Fasting serum samples were analyzed for NT levels using ELISA. Logistic regression, Wilcoxon rank sum, and Spearman’s rank tests were used for statistical analysis. Results. Thirty children (18 females, 2.2-15.9 years old) were enrolled. Of 25 patients who underwent endoscopy, 9 were CD patients, 13 were controls, and 3 were excluded due to nonspecific inflammation at duodenal biopsy. CD was diagnosed in 5 patients without biopsy. NT median was higher in CD patients compared to controls (13.25 (IQR 9.4-17.5) pg/ml vs. 7.8 (IQR 7.6-10) pg/ml; p=0.02). No statistically significant association between NT and clinical, serological, or histological data of CD was observed in this CD cohort. Conclusions. To our knowledge, this is the first study that evaluates NT in CD children from Italy. Results show that NT is higher in the serum of CD children at diagnosis compared to controls. However, larger-scale studies are required to validate these findings. Whether serum NT levels can be an adjunctive marker for pediatric CD remains currently elusive.

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Neurotensin serum levels and skin gene expression are increased in atopic dermatitis

Abstract: These results suggest that interactions between NT and mast cells may occur and contribute to AD pathogenesis.

Cited by 12 publications

References 16 publications

Emerging role of neurotensin in regulation of the cardiovascular system

Emerging role of neurotensin in regulation of the cardiovascular system

Targeting IL-33 in Autoimmunity and Inflammation

Fasting Neurotensin Levels in Pediatric Celiac Disease Compared with a Control Cohort

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