Neurotensin and Neuroendocrine Regulation

Rostène, William; Alexander, Mark J.

doi:10.1006/frne.1996.0146

Cited by 145 publications

(107 citation statements)

References 306 publications

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“…NT agonists or antagonists have been suggested to be of potential use for the treatment of pain, eating disorders, psychotic troubles, drug abuse and stress [6,36,64,37]. Moreover, NT acts as a growth factor on different classes of normal and cancer cells, and NT-related ligands are proposed to represent valuable tools for tumor targeting [29,61].…”

Section: Introductionmentioning

confidence: 99%

Interactions between neurotensin receptors and G proteins

Pélaprat

2006

Peptides

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Abstract:Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belonging to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towards all NTS1-mediated pathways, this peptide exerts agonist or antagonist activities depending on the considered NTS2-mediated pathway. Studies on these receptors reinforce the concept of independence between multiple signals potentially mediated through a single GPCR, generating a wide diversity of functional responses depending on the host cell and the ligand.

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Section: Introductionmentioning

confidence: 99%

Interactions between neurotensin receptors and G proteins

Pélaprat

2006

Peptides

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“…There is now clear evidence that NT is an important neuroendocrine regulator of the hypothalamo-pituitary system (McCann & Vijayan 1992, Rostène & Alexander 1997. In particular, in the frog, fNT stimulates the electrical and secretory activity of melanotrope cells through an activation of a receptor whose pharmacological profile shares similarities with mammalian NTR1 , Desrues et al 1998, Belmeguenai et al 2000.…”

Section: Discussionmentioning

confidence: 99%

“…Strong evolutionary pressure has acted to conserve the structure of the C-terminal hexapeptide of NT(8-13) from amphibians to mammals (Table 2) and this region is known to bear the biological activity of the peptide (Rostène & Alexander 1997). In accord, NT(8-13) was found to have the same potency as hNT and fNT in inducing activation of bfNTR1 and bfNTR4.…”

Section: Discussionmentioning

confidence: 99%

“…NT exhibits a dual function as a neurotransmitter or neuromodulator in the central nervous system and as a local hormone at the periphery. Central administration of NT induces various effects including modulation of dopaminergic transmission, naloxone-independent analgesia, inhibition of food intake and modulation of pituitary hormone release (Rostène & Alexander 1997, Kitabgi 2002. There is also increasing evidence that NT plays a role in neuropsychiatric diseases, notably in schizophrenia and Parkinson's disease (McMahon et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Molecular cloning and functional characterization of a type-I neurotensin receptor (NTR) and a novel NTR from the bullfrog brain

Li¹,

Sicard²,

salam³

et al. 2005

Journal of Molecular Endocrinology

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Neurotensin (NT) is a tridecapeptide that functions as a neurotransmitter and neuromodulator in the nervous system. To date, three different types of NT receptor (NTR), NTR1, NTR2 and NTR3, have been identified only in mammalian species. In the present study we isolated the cDNAs for an NTR1 and a novel NTR in the bullfrog brain, designated bfNTR1 and bfNTR4 respectively. bfNTR1 and bfNTR4 encode 422-and 399-amino acid residue proteins respectively. bfNTR1 has a 64% amino acid identity with mammalian NTR1, and 34-37% identity with mammalian NTR2. bfNTR4 exhibits 43% and 45-47% identity with mammalian NTR1 and NTR2 respectively. Both receptors are mainly expressed in the brain and pituitary. bfNTR1 triggers both CRE-luc, a protein kinase A (PKA)-specific reporter, and c-fos-luc, a PKC-specific reporter, activities, indicating that bfNTR1 can activate PKA-and PKC-linked signaling pathways. However, bfNTR4 appears to be preferentially coupled to the PKA-linked pathway as it induces a higher CRE-luc activity than c-fos-luc activity. bfNTRs exhibit different pharmacological properties as compared with mammalian NTRs. Mammalian NTR1 but not NTR2 responds to NT, whereas both bfNTR1 and bfNTR4 show a high sensitivity to NT. SR 48692 and SR 142948A, antagonists for mammalian NTR1 but agonists for mammalian NTR2, function as antagonists for both bfNTR1 and bfNTR4. In conclusion, this report provides the first molecular, pharmacological and functional characterization of two NTRs in a non-mammalian vertebrate. These data should help to elucidate the phylogenetic history of the G protein-coupled NTRs in the vertebrate lineage as well as the structural features that determine their pharmacological properties.

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“…Par le fait que le CRH était lui-même sous la dépen-dance des corticoïdes surrénaliens, un champ nouveau de recherche a été ouvert par le Dr Claude Fortier pour étudier les mécanismes intervenant dans les effets des stéroïdes sur les neuropeptides au niveau central. C'est ainsi qu'a été décrite l'influence des corticoïdes sur la synthèse, le taux et la sécrétion neuronale de CRH [15], de vasopressine [16], du peptide vasoactif intestinal [17] et de la neurotensine [18], ces neuropeptides ayant, comme le CRH, un rôle important dans la réponse au stress.…”

Section: Stress Corticoïdes Et Peptides Hypothalamiquesunclassified

Claude Fortier : une grande histoire de la neuroendocrinologie

Rostène

2005

Med Sci (Paris)

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Neurotensin and Neuroendocrine Regulation

Cited by 145 publications

References 306 publications

Interactions between neurotensin receptors and G proteins

Interactions between neurotensin receptors and G proteins

Molecular cloning and functional characterization of a type-I neurotensin receptor (NTR) and a novel NTR from the bullfrog brain

Claude Fortier : une grande histoire de la neuroendocrinologie

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