Neurotensin and Bombesin

Nemeroff, Charles B.; Luttinger, Daniel; PrangeJr., Arthur J.

doi:10.1007/978-1-4613-3515-3_6

Cited by 38 publications

(13 citation statements)

References 284 publications

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“…There is however an increasing body of evidence that one of the earliest steps in neurotensin There is now evidence that neurotensin acts as a action is an increase in cellular inositol phosphate neurotransmitter or neuromodulator in the central ner-content. This has been demonstrated in slices of brain vous system [1] and as a hormone in the gastrointestinal tissue [3], in pituitary cells [4], in the neuroblastoma tract [2]. Although the properties and characteristics of N El 15 cell line [5] and in the human colonic adenoneurotensin binding to its receptors on target cells have carcinoma HT29 cell line [6].…”

Section: Introductionmentioning

confidence: 99%

Neurotensin stimulates inositol trisphosphate-mediated calcium mobilization but not protein kinase C activation in HT29 cells. Involvement of a G-protein

Bozou¹,

Rochet

Magnaldo

et al. 1989

Biochemical Journal

104

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It has previously been shown that neurotensin binds to high-affinity receptors in the adenocarcinoma HT29 cell line, and that receptor occupancy leads to inositol phosphate formation. The present study was designed to investigate further the effects of neurotensin on calcium mobilization and protein kinase C (PKC) activation in HT29 cells, and to assess the role of GTP-binding proteins (G-proteins)

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Section: Introductionmentioning

confidence: 99%

Neurotensin stimulates inositol trisphosphate-mediated calcium mobilization but not protein kinase C activation in HT29 cells. Involvement of a G-protein

Bozou¹,

Rochet

Magnaldo

et al. 1989

Biochemical Journal

104

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“…Several neurotensin pathways have been described in rodent brain, but their functional significance remains to be elucidated. For review of neurotensin and bombesin topography see Nemeroff and co-workers [17] and Palkovits 1191.…”

Section: Discussionmentioning

confidence: 99%

Alterations in regional brain concentrations of neurotensin and bombesin in Parkinson's disease

Bissette

Nemeroff

Decker³

et al. 1985

Annals of Neurology

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Frozen samples of postmortem human brain tissue from patients with Parkinson's disease (n = 25) and control patients who died without neurological disease (n = 25) were assayed for neurotensin and bombesin by specific radioimmunoassay. Twelve brain regions were examined: substantia nigra, ventral tegmental area, periaqueductal gray matter, caudate nucleus, putamen, globus pallidus, amygdala, hippocampus, nucleus accumbens, frontal cortex, cingulate cortex, and entorhinal cortex. In patients with Parkinson's disease, the concentration of bombesin was significantly decreased in the caudate nucleus and globus pallidus, and the concentration of neurotensin was significantly reduced in the hippocampus. The concentration of neither peptide was significantly altered in the substantia nigra or ventral tegmental area, two regions known to exhibit reductions in other neurotransmitter substances.

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“…Whereas no xenopsin-like immunoreactivity is present in mammalian tissues (Goedert et al, in press) neurotensin-like immunoreactivity is found throughout the central nervous system of mammals (Emson et al 1982). In peripheral tissues, it is present in high concentrations in the anterior pituitary gland and the gastrointestinal mucosa and in low concentrations in most other tissues, including the lung (Goedert et (Nemeroff et al, 1983). (Lowry et al, 1951), using bovine serum albumin as the standard.…”

mentioning

confidence: 99%