Neurosyphilis : une cause rare de myélite

Louhab, Nissrine; Hajjaj, Imane; Kissani, Najib

doi:10.1016/j.lpm.2009.11.013

Cited by 2 publications

(1 citation statement)

References 8 publications

(7 reference statements)

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“…Physicians should still be aware of this cause of HP because syphilis has been increasing worldwide due to reasons such as sexual and social norm changes, interaction with the HIV infection, substance abuse, global travel and migration, and underinvestment in public-health services [12,13]. …”

Section: Discussionmentioning

confidence: 99%

Hypertrophic cervical spinal cord pachymeningitis due to Treponema pallidum infection

Vale

Moraes²,

Lara

et al. 2011

Neurol Sci

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Neurosyphilis is recognized as a potential cause of hypertrophic pachymeningitis, but modern reports are few. A middle-aged man presented to hospital with a 1 month history of lower limb pain and weakness. Cerebrospinal fluid analysis showed pleocytosis with high protein levels and a positive venereal disease research laboratory result. Cervical spinal cord resonance imaging disclosed a dural contrast enhancement suggestive of pachymeningitis. Biopsy of the dura mater revealed a thick inflammatory process. Despite being treated accordingly, the patient rapidly deteriorated and died. The patient was diagnosed as having subacute hypertrophic cervical pachymeningitis which caused spinal cord compression. Serological evidence of neurosyphilis was present. Physicians should still be aware of this cause of hypertrophic pachymeningitis.

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Section: Discussionmentioning

confidence: 99%

Hypertrophic cervical spinal cord pachymeningitis due to Treponema pallidum infection

Vale

Moraes²,

Lara

et al. 2011

Neurol Sci

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Changes in neurosyphilis presentation: a survey on 286 patients

Drago

Merlo

Ciccarese

et al. 2016

Acad Dermatol Venereol

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Although neurosyphilis (NS) keeps plaguing worldwide, often with oligosymptomatic and atypical manifestations, the most recent reports fail to provide useful information, like details of the clinical history and even of the previous early therapy. We conducted a survey of the literature of the last 5 years on the clinical presentation of NS, recording the aforementioned inaccuracies. One hundred and thirty-seven articles were collected, reporting on 286 patients. General paresis was the commonest form (49%), often manifesting with cognitive impairment and psychiatric symptoms. Syphilitic meningitis was found in 63 patients (22%), mainly with ocular or auditory involvement. Meningovascular and tabetic form were both found in 12% of cases. Gummatous and epileptic manifestations were rare. Perusal of the literature confirms that NS prevalence is increasing, often with manifestations that are atypical for timing and type of lesions. Unfortunately, many articles are lacking of critical information, like an accurate clinical history and timing of the therapy making difficult to assess the effectiveness of penicillin in preventing NS.

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Neurosyphilis : une cause rare de myélite

Cited by 2 publications

References 8 publications

Hypertrophic cervical spinal cord pachymeningitis due to Treponema pallidum infection

Hypertrophic cervical spinal cord pachymeningitis due to Treponema pallidum infection

Changes in neurosyphilis presentation: a survey on 286 patients

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