Neurosyphilis in Acquired Immunodeficiency Syndrome-Reply

Katz, Debra A.; Berger, Joseph

doi:10.1001/archneur.1990.00530060024009

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Patients were also examined for gait, unilateral weakness, and sensory modalities and were all found to be normal. This is in contrast with the study done US by Katz et al which had found 12 patients with neurosyphilis 4,of whom had eye problems, 3 with altered mental status and five with unilateral weakness (16). Of note, a major difference between the Tanzania and the US study is that not all US patients were on ART, whereas all but one of the Tanzanian study patients were on ART.…”

Section: Discussionmentioning

confidence: 56%

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Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

Haule

Msemwa

Mgaya

et al. 2020

Preprint

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Section: Discussionmentioning

confidence: 56%

“…For those who had syphilis, only two-thirds (66.7%) received treatment. The majority received three intramuscular penicillin doses according to CDC recommendation, as also reported by Katz and colleagues (16).…”

Section: Discussionmentioning

confidence: 77%

Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

Haule

Msemwa

Mgaya

et al. 2020

Preprint

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“…Syphilis. Immunosuppressed patients, especially those with AIDS, show increased susceptibility to infection by Treponema pallidum (14,15). The rate of progression and severity of the disease are accelerated in these individuals.…”

Section: Bacteriamentioning

confidence: 99%

Neuropathology of Immunosuppression

1992

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Traditionally, the brain has been considered an "immunologically privileged" organ. Under normal conditions, the blood-brain barrier (BBB) is highly effective in preventing both cellular and humoral constituents of the blood from entering the brain parenchyma. In certain pathological conditions, such as viral infections and demyelinating disorders, the BBB may become altered, activated T cells and monocytes may gain access to the brain parenchyma, and microglia may assume the functions of antigen-presenting cells and macrophages. Naturally-occurring or clinically-induced immunosuppression may dramatically alter various cellular and/or humoral aspects of the immune system. Consequently, the brain may become susceptible to disorders that would otherwise be excluded or may develop more severe manifestations of diseases, such as certain infections. This review considers the neuropathologic aspects of various conditions that may be encountered in the setting of both acquired and inherited immunosuppression. The major categories include infectious, neoplastic, vascular, and metabolic disorders. The review also briefly addresses the neuropathology of complications of chemotherapeutic agents, radiotherapy, and organ transplantation inasmuch as they often occur in the clinical setting of acquired immunosuppression.

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Neurosyphilis in Acquired Immunodeficiency Syndrome-Reply

Cited by 2 publications

References 6 publications

Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

Prevalence Of Syphilis, Neurosyphilis And Associated Factors In a Cross-Sectional Analysis Of HIV Infected Patients Attending Bugando Medical Centre Mwanza Tanzania

Neuropathology of Immunosuppression

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