Neurostimulation for Memory Enhancement in Epilepsy

Meisenhelter, Stephen; Jobst, Barbara C.

doi:10.1007/s11910-018-0837-3

Cited by 19 publications

(9 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…96 This treatment has shown promise in the treatment of idiopathic/genetic generalized epilepsy with stimulation in thalamic nuclei and may additionally serve in the future as a possible future treatment to address memory deficits associated with epilepsy. 97,98 Collectively, these findings emphasize the importance of considering network configuration and specifically the involvement of hub nodes in seizure networks and achievement of seizure freedom.…”

Section: Hub Mapping As a Clinical Toolmentioning

confidence: 85%

Epilepsy and brain network hubs

et al. 2022

View full text Add to dashboard Cite

Epilepsy is a disorder of brain networks. A better understanding of structural and dynamic network properties may improve epilepsy diagnosis, treatment, and prognostics. Hubs are brain regions with high connectivity to other parts of the brain and are typically situated along the brain's most efficient communication pathways, supporting large-scale brain wiring and many higher order neural functions. The visualization and analysis of hubs offers a perspective on regional and global network organization and can provide novel insights into brain disorders and epilepsy. By notably supporting the interaction between various brain networks, hubs may be implicated in seizure spread and in epilepsy-related phenotypes. In this review, we will discuss the growing literature on atypical hub organization in common epilepsy syndromes, both related to neuroimaging of brain structure and function, and related to neurophysiological data from magneto-and electroencephalographic measures of neural dynamics. With studies increasingly exploring the clinical utility of network neuroscience approaches, we highlight the potential of hub mapping as a candidate biomarker of cognitive dysfunction and postsurgical seizure outcome. We will conclude the review with a discussion of current limitations and outlook for future research.

show abstract

Section: Hub Mapping As a Clinical Toolmentioning

confidence: 85%

Epilepsy and brain network hubs

et al. 2022

View full text Add to dashboard Cite

show abstract

“…DBS and RNS side effects are usually device-related and relatively rare. Memory and cognition either appear to be not affected or to be potentially improved, particularly with intracranial stimulation of the lateral temporal structures and fornix [122]. With DBS ANT, there has been an increased frequency of subjective memory or mood complaints [57].…”

Section: Discussionmentioning

confidence: 99%

A Review of Neurostimulation for Epilepsy in Pediatrics

et al. 2019

View full text Add to dashboard Cite

Neurostimulation for epilepsy refers to the application of electricity to affect the central nervous system, with the goal of reducing seizure frequency and severity. We review the available evidence for the use of neurostimulation to treat pediatric epilepsy, including vagus nerve stimulation (VNS), responsive neurostimulation (RNS), deep brain stimulation (DBS), chronic subthreshold cortical stimulation (CSCS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). We consider possible mechanisms of action and safety concerns, and we propose a methodology for selecting between available options. In general, we find neurostimulation is safe and effective, although any high quality evidence applying neurostimulation to pediatrics is lacking. Further research is needed to understand neuromodulatory systems, and to identify biomarkers of response in order to establish optimal stimulation paradigms.

show abstract

“…Such a framework could contribute to the formulation of new treatment targets for the cognitive impairments that many patients suffer from. For instance, neurostimulation to remaining parts of the DMN may induce cellular and functional network changes that go hand in hand with cognitive improvement ( Meisenhelter and Jobst 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Cellular Substrates of Functional Network Integration and Memory in Temporal Lobe Epilepsy

et al. 2021

View full text Add to dashboard Cite

Temporal lobe epilepsy (TLE) patients are at risk of memory deficits, which have been linked to functional network disturbances, particularly of integration of the default mode network (DMN). However, the cellular substrates of functional network integration are unknown. We leverage a unique cross-scale dataset of drug-resistant TLE patients (n = 31), who underwent pseudo resting-state functional magnetic resonance imaging (fMRI), resting-state magnetoencephalography (MEG) and/or neuropsychological testing before neurosurgery. fMRI and MEG underwent atlas-based connectivity analyses. Functional network centrality of the lateral middle temporal gyrus, part of the DMN, was used as a measure of local network integration. Subsequently, non-pathological cortical tissue from this region was used for single cell morphological and electrophysiological patch-clamp analysis, assessing integration in terms of total dendritic length and action potential rise speed. As could be hypothesized, greater network centrality related to better memory performance. Moreover, greater network centrality correlated with more integrative properties at the cellular level across patients. We conclude that individual differences in cognitively relevant functional network integration of a DMN region are mirrored by differences in cellular integrative properties of this region in TLE patients. These findings connect previously separate scales of investigation, increasing translational insight into focal pathology and large-scale network disturbances in TLE.

show abstract

Neurostimulation for Memory Enhancement in Epilepsy

Cited by 19 publications

References 71 publications

Epilepsy and brain network hubs

Epilepsy and brain network hubs

A Review of Neurostimulation for Epilepsy in Pediatrics

Cellular Substrates of Functional Network Integration and Memory in Temporal Lobe Epilepsy

Contact Info

Product

Resources

About