Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus

Saalmann, Yuri B.; Morgan, Ian G.; Calford, Michael B.

doi:10.1152/jn.00786.2006

Cited by 17 publications

(8 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although steroids influence auditory encoding in the peripheral nervous system35,36, there are few studies that address a neuromodulatory role for steroids on central mechanisms of audition. Steroids exert long-term, genomic actions on auditory processing within the inferior colliculus in rats37, and within NCM in songbirds38. This study now predicts that brain-derived steroids acutely modulate auditory processing within pallial/cortical regions, which could provide clues about the function of neuronal aromatase expression within auditory cortex of other vertebrates, including humans39.…”

Section: Discussionmentioning

confidence: 63%

Forebrain steroid levels fluctuate rapidly during social interactions

2008

View full text Add to dashboard Cite

Neurosteroids are powerful modulators of brain function and behavior, yet their dynamics within the brain have remained elusive. Using in vivo microdialysis in male zebra finches, we show that local estradiol levels increase rapidly within the forebrain during social interactions with females. Further, when males are exposed to other males’ song, local estradiol levels also increase and testosterone levels drop within a cortical/pallial auditory region that is analogous to mammalian auditory cortex. We also report that local estradiol and testosterone levels are differentially regulated in this same region by the conventional neurotransmitters glutamate and GABA, respectively. This study provides direct evidence that forebrain steroid levels are acutely and differentially regulated during social behavior, in a region-specific manner, and in a rapid time-course akin to that of traditional neuromodulators.

show abstract

Section: Discussionmentioning

confidence: 63%

Forebrain steroid levels fluctuate rapidly during social interactions

2008

View full text Add to dashboard Cite

show abstract

“…The available data suggests that elevations of 3α,5α-THP within a cell reduce the excitability of that particular cell (Akk et al 2007; Saalmann et al 2006; Tokuda et al 2011; Tokuda et al 2010). 3α,5α-THP may access the neuroactive steroid transmembrane binding sites on GABA A receptors via intracellular (i.e.…”

Section: Pharmacological Properties Of Neuroactive Steroidsmentioning

confidence: 99%

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies

Porcu

Morrow

2014

Psychopharmacology

View full text Add to dashboard Cite

Rationale Neuroactive steroids are endogenous or synthetic steroids that rapidly alter neuronal excitability via membrane receptors, primarily GABAA receptors. Neuroactive steroids regulate many physiological processes including hypothalamic-pituitary-adrenal (HPA) axis function, ovarian cycle, pregnancy, aging, and reward. Moreover, alterations in neuroactive steroid synthesis are implicated in several neuropsychiatric disorders. Objectives This review will summarize the pharmacological properties and physiological regulation of neuroactive steroids, with a particular focus on divergent neuroactive steroid responses to stress and ethanol in rats, mice and humans. Results GABAergic neuroactive steroids exert a homeostatic regulation of the HPA axis in rats and humans, whereby the increase in neuroactive steroid levels following acute stress counteracts HPA axis hyperactivity and restores homeostasis. In contrast, in C57BL/6J mice, acute stress decreases neurosteroidogenesis and neuroactive steroids exert paradoxical excitatory effects upon the HPA axis. Rats, mice and humans also differ in the neuroactive steroid responses to ethanol. Genetic variation in neurosteroidogenesis may explain the different neuroactive steroid responses to stress or ethanol. Conclusions Rats and mouse strains show divergent effects of stress and ethanol on neuroactive steroids in both plasma and brain. The study of genetic variation in the various processes that determine neuroactive steroids levels as well as their effects on cell signaling may underlie these differences and may play a relevant role for the potential therapeutic benefits of neuroactive steroids.

show abstract

“…After selectively blocking the GABAergic innervation of the central nucleus of the inferior colliculus by afferents of the dorsal nucleus of the lateral lemniscus, enhanced local production of allopregnanolone provided compensation by increasing the efficacy of the other inhibitory inputs (Saalmann et al, 2006). …”

Section: Sources Of Progesterone In the Central Nervous Systemmentioning

confidence: 99%

Progesterone Synthesis in the Nervous System: Implications for Myelination and Myelin Repair

Schumacher¹,

Hussain²,

Gago³

et al. 2012

Front. Neurosci.

174

111

View full text Add to dashboard Cite

Progesterone is well known as a female reproductive hormone and in particular for its role in uterine receptivity, implantation, and the maintenance of pregnancy. However, neuroendocrine research over the past decades has established that progesterone has multiple functions beyond reproduction. Within the nervous system, its neuromodulatory and neuroprotective effects are much studied. Although progesterone has been shown to also promote myelin repair, its influence and that of other steroids on myelination and remyelination is relatively neglected. Reasons for this are that hormonal influences are still not considered as a central problem by most myelin biologists, and that neuroendocrinologists are not sufficiently concerned with the importance of myelin in neuron functions and viability. The effects of progesterone in the nervous system involve a variety of signaling mechanisms. The identification of the classical intracellular progesterone receptors as therapeutic targets for myelin repair suggests new health benefits for synthetic progestins, specifically designed for contraceptive use and hormone replacement therapies. There are also major advantages to use natural progesterone in neuroprotective and myelin repair strategies, because progesterone is converted to biologically active metabolites in nervous tissues and interacts with multiple target proteins. The delivery of progesterone however represents a challenge because of its first-pass metabolism in digestive tract and liver. Recently, the intranasal route of progesterone administration has received attention for easy and efficient targeting of the brain. Progesterone in the brain is derived from the steroidogenic endocrine glands or from local synthesis by neural cells. Stimulating the formation of endogenous progesterone is currently explored as an alternative strategy for neuroprotection, axonal regeneration, and myelin repair.

show abstract

Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus

Cited by 17 publications

References 57 publications

Forebrain steroid levels fluctuate rapidly during social interactions

Forebrain steroid levels fluctuate rapidly during social interactions

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies

Progesterone Synthesis in the Nervous System: Implications for Myelination and Myelin Repair

Contact Info

Product

Resources

About