Neurosteroids Dehydroepiandrosterone and Its Sulfate in Individuals with Personality Disorders Convicted of Serious Violent Crimes

Gavrilova, V. A.; Ivanova, Svetlana A.; Gusev, S.; Трофимова, М В; Бохан, Н. А.

doi:10.1007/s10517-012-1882-6

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…By contrast, rats and mice lack the specific enzyme 17a-hydroxylase necessary to synthesize and secrete adrenal androgens ( [25], reviewed in [7,26]), making them an inappropriate model for the study of adrenal-derived androgens. DHEA and aggression appear positively correlated in humans [27,28], and individuals who are deficient in cortisol (CORT) synthesis (i.e. congenital adrenal hyperplasia) show elevated DHEA concomitant with increased aggression [29,30].…”

Section: Introductionmentioning

confidence: 99%

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

et al. 2015

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Classic findings have demonstrated an important role for sex steroids as regulators of aggression, but this relationship is lacking within some environmental contexts. In mammals and birds, the adrenal androgen dehydroepiandrosterone (DHEA), a non-gonadal precursor of biologically active steroids, has been linked to aggression. Although females, like males, use aggression when competing for limited resources, the mechanisms underlying female aggression remain understudied. Here, we propose a previously undescribed endocrine mechanism regulating female aggression via direct action of the pineal hormone melatonin on adrenal androgens. We examined this in a solitary hamster species, Phodopus sungorus, in which both sexes are highly territorial across the seasons, and display increased aggression concomitant with decreased serum levels of sex steroids in short 'winter-like' days. Short-but not long-day females had increased adrenal DHEA responsiveness co-occurring with morphological changes in the adrenal gland. Further, serum DHEA and total adrenal DHEA content were elevated in short days. Lastly, melatonin increased DHEA and aggression and stimulated DHEA release from cultured adrenals. Collectively, these findings demonstrate that DHEA is a key peripheral regulator of aggression and that melatonin coordinates a 'seasonal switch' from gonadal to adrenal regulation of aggression by direct action on the adrenal glands.

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Section: Introductionmentioning

confidence: 99%

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

et al. 2015

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“…При P ниже 0,48 и оценке по методике СОРОП ниже либо равной (-)20 делается заключение о низком риске агрессивного поведения больного в настоящее время и совершения им ООД насильственного характера в будущем. При Р выше либо равном 0,48 и оценке по методике СОРОП ниже либо равной (+) 19…”

Section: процедура проведения оценкиunclassified

“…В последние годы обоснована необходимость изучения патогенетических механизмов развития поведенческих нарушений, сопровождающихся агрессивными тенденциями у психически больных, потенциально опасных для общества. Исследователями подчеркивается важность определения роли дисрегуляции серотонин-и дофаминергической, гипоталамогипофизарно-надпочечниковой и гипоталамогипофизарно-гонадной систем в развитии агрессивных тенденций у данной категории лиц [18,19,20,21,22,23,24,25] Применялся лабораторный метод, включающий определение биогенных аминов (серотонина, дофамина) в моче и уровней гормонов (тестостерона, кортизола, эстрадиола, трийодтиронина свободного -Т3 св) в крови респондентов. Известно, что уровень биогенных аминов (в частности серотонина) в сыворотке крови варьирует в зависимости от времени суток, потребляемых продуктов питания, лекарственных препаратов, стрессорных реакций и др., что существенно снижает его диагностическую специфичность [26].…”

Section: Introductionunclassified

Способ Оценки Риска Общественно Опасного Агрессивного Поведения У Лиц С Тяжелыми Психическими Расстройствами

Макушкина,

Леурда

2023

СВПН

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Background. The tendency to aggression is a factor contributing to the social danger of persons with mental disorders. Existing approaches and methods make it possible to assess predominantly clinical-psychopathological, anamnestic and social parameters that affect the likelihood of committing socially dangerous acts. Tools for assessing the likelihood of aggression based on biological predictors are currently not available. Objective: development of a technology for determining the risk of socially dangerous aggressive behavior in persons with severe mental disorders with the assessment of biological indicators. Materials and Methods. The technology was developed based on the results of a survey of 219 respondents diagnosed with a severe mental disorder (ICD-10 codes F00-09, F20-29, F70-72). The main group (n=105) included patients with persistent aggressive behavior who committed violent offences; comparison group (n=114)patients with law-abiding behavior. Results. With the help of mathematical and statistical tools, a Method for assessing the risk of socially dangerous aggressive behavior in persons with severe mental disorders was developed. The method consists in the complex application of the laboratory research method and psychometry. At the first stage, urine and blood are taken from the subject, followed by determination of the levels of serotonin in the urine and hormonescortisol and testosterone in the blood. Further, based on the data obtained, the regression equation is calculated using a special formula. At the second stage, screening of potential social danger is provided according to the method of structured risk assessment of dangerous behavior (SOROP). At the third stage, based on the results of the complex application of the laboratory method of research and psychometry, a conclusion is made about the risk of the patient's aggressive behavior, the likelihood of his/her committing socially dangerous actions of a violent nature. Conclusion. The method can be used in addition to clinical assessment to improve the accuracy of predicting the likelihood of socially dangerous aggressive behavior of persons with severe mental disorders.

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“…Compounds as dehydroepiandrosterone, androstenedione, and deoxycorticosterone meet the requirements to be categorized as neuroactive steroids. Interestingly, neuroactive steroids induce responses on GABA receptors and modulate the activity of 5α and 3α reductases affecting steroid synthesis [130][131][132]. In this regard, neuroactive steroids can be exogenously synthesized and produce similar effects on the CNS.…”

Section: Neuroactive Steroidsmentioning

confidence: 99%

Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions

Toro-Urrego¹,

Ávila-Rodriguez²,

Herrera³

et al. 2020

Neuroprotection - New Approaches and Prospects

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Hypoxic–ischemic brain injury is a number one cause of long-term neurologic disability and death worldwide. This public health burden is mainly characterized by a decrease in oxygen concentration and blood flow to the tissues, which lead to an inefficient supply of nutrients to the brain. This condition induces cell death by energy depletion and increases free radical generation and inflammation. Hypoxic–ischemic brain injury may occur in ischemic-stroke and over perinatal asphyxia, being both leading causes of morbidity in adults and children, respectively. Currently, there are no effective pharmaceutical strategies to prevent the triggering of secondary injury cascades, including oxidative stress and metabolic dysfunction. Neuroactive steroids like selective estrogen receptor modulators, SERMs, and selective tissue estrogenic activity regulators, STEARs, exert several neuroprotective effects. These encompass mitochondrial survival, a decrease in reactive oxygen species, and maintenance of cell viability, among others. In this context, these neurosteroids constitute promising molecules, which could modify brain response to injury. Here we show an updated overview of the underlying mechanisms of hypoxic–ischemic brain injury. We also highlight the neuroprotective effects of neurosteroids and their future directions.

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Neurosteroids Dehydroepiandrosterone and Its Sulfate in Individuals with Personality Disorders Convicted of Serious Violent Crimes

Cited by 9 publications

References 8 publications

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens

Способ Оценки Риска Общественно Опасного Агрессивного Поведения У Лиц С Тяжелыми Психическими Расстройствами

Neuroactive Steroids in Hypoxic–Ischemic Brain Injury: Overview and Future Directions

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