Neurosteroids and their neuroprotective actions

Borowicz-Reutt, Kinga K.

doi:10.2991/hsic-17.2017.35

Cited by 1 publication

(1 citation statement)

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“…In the animal model of PD, PROG, and 17β-estradiol protected against the degeneration of dopaminergic neurons induced by neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) [176]. Interestingly, the levels of neuroprotective NS, such as PROG and ALLO, are lowered in the cerebrospinal fluid of PD patients [177]. Some of the beneficial effects of NSs on PD might be attributed to mild negative modulation of the M 4 receptors by 17β-estradiol and PROG as PROG slightly decreases the efficacy of ACh, and 17β-estradiol decreases its potency at this receptor [13].…”

Section: Parkinson's Diseasementioning

confidence: 98%

Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids

Szczurowska

Szánti-Pintér

Chetverikov

et al. 2022

IJMS

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Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer’s disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions.

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Section: Parkinson's Diseasementioning

confidence: 98%