Neurosteroid hormone vitamin D and its utility in clinical nutrition

Kalueff, Allan V.; Tuohimaa, Pentti

doi:10.1097/mco.0b013e328010ca18

Cited by 242 publications

(297 citation statements)

References 88 publications

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“…(8,9,30,31) For example, vitamin D status has been associated with cognitive function such as attention, which is involved in gait control in older adults. (32)(33)(34)(35)(36) Fast-pace walking is precisely considered as a more attention-demanding task than usual-pace walking, (23,36) which could explain in part the close positive association shown in our study.…”

Section: Discussionsupporting

confidence: 58%

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

Annweiler

Schott

Montero‐Odasso

et al. 2010

Journal of Bone and Mineral Research

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The purpose of this study was to determine whether there was an association between serum 25-hydroxyvitamin D [25(OH)D] concentration and walking speed measured at usual and fast pace among older women. Usual-and fast-pace walking speeds and 25(OH)D concentrations were assessed in 739 randomized older women (mean age 80.2 AE 3.5 years) from the EPIDOS study. The following 25(OH)D thresholds were used: 10, 20, and 30 ng/mL. Walking speed was dichotomized on being in the worst quintile or not. Age, body mass index, number of chronic diseases, physical activity, quadriceps strength, cognition, use of psychoactive drugs, and serum parathyroid hormone were used as potential confounders. The results show that 90% of subjects had 25(OH)D insufficiency. Only fast-pace walking speed was significantly different between groups ( p ¼ .

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Section: Discussionsupporting

confidence: 58%

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

Annweiler

Schott

Montero‐Odasso

et al. 2010

Journal of Bone and Mineral Research

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“…Various neuroprotective effects of vitamin D in the CNS and the eye may explain these associations. In vitro, vitamin D increases the synthesis of neurotrophic agents such as the Nerve Growth Factor (NGF) and the Glial cell lineDerived Neurotrophic Factor (GDNF), and regulates neuronal differentiation and maturation [26,27]. It also accelerates neuronal growth in a dose-dependent way in rat hippocampal cell cultures [28].…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

et al. 2015

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a b s t r a c tObjectives: Vitamin D is involved in visual health and function. Our objective was to determine whether age-related vitamin D insufficiency was associated with the presence and the severity of primary open angle glaucoma (POAG) in a case-control study of older adults. Study design: Case-control study.Main outcome measures. One hundred fifty cases diagnosed with moderate-to-severe POAG (mean, 75.1 ± 8.5 years; 42.0% female) and 164 healthy controls (mean, 73.0 ± 7.9 years; 59.8% female) were included. POAG diagnosis was based on classical diagnostic criteria of optic nerve cupping and/or RNFL thinning, measured with optical coherence tomography. Severe POAG was defined as Humphrey visual field mean deviation (MD) worse than −12 dB. Vitamin D insufficiency was defined as serum 25OHD ≤ 75 nmol/L. Age, gender, mean arterial pressure, vitamin D supplementation, visual acuity, and intraocular pressure were used as potential confounders. Results: POAG cases had lower mean serum 25OHD concentration than controls (42.9 ± 25.7 nmol/L versus 49.4 ± 29.5 nmol/L, P = 0.039) and a greater prevalence of vitamin D insufficiency (90.7% versus 82.3%, P = 0.032). Increased mean serum 25OHD concentrations were associated with lower POAG frequency, even after adjustment for potential confounders (OR = 0.89 per 10 nmol/L of 25OHD, P = 0.045). Similarly, vitamin D insufficiency was associated with POAG (OR = 2.09, P = 0.034). Among POAG cases, no 25OHD difference was observed between moderate and severe POAG cases (respectively, 39.2 ± 23.3 nmol/L versus 45.1 ± 26.7 nmol/L, P = 0.188); and no between-group difference regarding the prevalence of vitamin D insufficiency (88.9% versus 94.0%, P = 0.313). Conclusions: Decreased serum 25OHD concentration was associated with POAG. There was no 25OHD difference between moderate and severe POAG.

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“…Reduced sun exposure probably reduces vitamin D serum values and theoretically decreases activated levels of vitamin D in growing brains. Autism is more prevalent in dark-skinned people (59)(60)(61)(62). Moreover, rigorous maternal vitamin D inadequacy is remarkably more prevalent in dark-skinned people.…”

Section: Discussionmentioning

confidence: 99%

“…Autism may extend due to gestational and early infantile vitamin D insufficiency, and lack of adequate to sun exposure. This condition is unfortunately unsuccessful to balance due to existence of the epidemic of vitamin D insufficiency (44,62). Every hypothesis on the etiology should consider its potent genetic basis and explain how genetic factors interrelate with the environment to cause the unusual epidemiology of autism.…”

Section: Discussionmentioning

confidence: 99%

“…Activated vitamin D3 has a strong pleiotropic neurosteroid hormone which plays a significant role in mammalian brain growth. Rigorous vitamin D deficiency in the period of pregnancy, significantly disturbs the development of the baby structure and brain growth (60)(61)(62). The physiology of calcitriol is exceptional amongst the steroid hormones while normal steroid feedback inhibition does not control neural levels of calcitriol.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D deficiency and autism; a review on recent findings

Sotodehasl¹,

Tamadon²,

Malek³

2017

J Parathyr Dis

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Autism is a group of lifelong developmental disabilities with various genetic and environmental risk factors which is generally not curable. The proportion of children with autism spectrum disorders (ASDs) has risen over the past decade. Few studies have focused on vitamin D status of patients with autism. Therefore, this study was aimed to further investigate the relationship between vitamin D deficiency and autism. In this short review, we discuss the relationship between vitamin D deficiency and ASDs. Our literature review yielded over 80 articles published since 2006 in the electronic databases of the Web of Knowledge, EBSCO, OVID and PubMed. As the results showed, no significant difference between children with and without autism regarding vitamin D serum levels was obtained. According to the controversial results on the correlation of vitamin D serum value and autism in children with ASD, it is necessary to conduct further studies in this field.

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Neurosteroid hormone vitamin D and its utility in clinical nutrition

Abstract: Vitamin D emerges as an important neurosteroid hormone in the brain, with a strong potential for age-specific applications in clinical nutrition.

Cited by 242 publications

References 88 publications

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

Vitamin D deficiency and autism; a review on recent findings

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